Anti-AIFM3 Antibody (CAB8597)
- SKU:
- CAB8597
- Product type:
- Antibody
- Application:
- WB
- Application:
- IHC
- Reactivity:
- Human
- Mouse
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Research Area:
- Cell Death
Frequently bought together:
Description
| Antibody Name: | Anti-AIFM3 Antibody |
| Antibody SKU: | CAB8597 |
| Antibody Size: | 20uL, 50uL, 100uL |
| Application: | WB IHC |
| Reactivity: | Human, Mouse, Rat |
| Host Species: | Rabbit |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-200 of human AIFM3 (NP_001018070.1). |
| Application: | WB IHC |
| Recommended Dilution: | WB 1:500 - 1:2000 IHC 1:50 - 1:200 |
| Reactivity: | Human, Mouse, Rat |
| Positive Samples: | THP-1, HeLa |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-200 of human AIFM3 (NP_001018070.1). |
| Purification Method: | Affinity purification |
| Storage Buffer: | Store at -20°C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| Isotype: | IgG |
| Sequence: | MGGC FSKP KPVE LKIE VVLP EKER GKEE LSAS GKGS PRAY QGNG TARH FHTE ERLS TPHP YPSP QDCV EAAV CHVK DLEN GQMR EVEL GWGK VLLV KDNG EFHA LGHK CPHY GAPL VKGV LSRG RVRC PWHG ACFN ISTG DLED FPGL DSLH KFQV KIEK EKVY VRAS KQAL QLQR RTKV MAKC ISPS AGYS SSTN VLIV |
| Gene ID: | 150209 |
| Uniprot: | Q96NN9 |
| Cellular Location: | Mitochondrion |
| Calculated MW: | 65kDa/66kDa |
| Observed MW: | 72kDa |
| Synonyms: | AIFM3, AIFL |
| Background: |
| UniProt Protein Function: | AIFM3: Induces apoptosis through a caspase dependent pathway. Reduces mitochondrial membrane potential. Belongs to the FAD-dependent oxidoreductase family. 3 isoforms of the human protein are produced by alternative splicing. |
| UniProt Protein Details: | Protein type:Endoplasmic reticulum; Mitochondrial; Apoptosis; EC 1.-.-.-; Oxidoreductase Chromosomal Location of Human Ortholog: 22q11.21 Cellular Component: mitochondrion; endoplasmic reticulum; mitochondrial inner membrane; nucleus Molecular Function:2 iron, 2 sulfur cluster binding; FAD binding; metal ion binding; oxidoreductase activity Biological Process: cell redox homeostasis |
| UniProt Code: | Q96NN9 |
| NCBI GenInfo Identifier: | 74732608 |
| NCBI Gene ID: | 150209 |
| NCBI Accession: | Q96NN9.1 |
| UniProt Secondary Accession: | Q96NN9,Q6ZT44, Q8N1V3, Q8N5E0, B7WP37, D3DX37, D3DX38 |
| UniProt Related Accession: | Q96NN9 |
| Molecular Weight: | 65,966 Da |
| NCBI Full Name: | Apoptosis-inducing factor 3 |
| NCBI Synonym Full Names: | apoptosis-inducing factor, mitochondrion-associated, 3 |
| NCBI Official Symbol: | AIFM3 |
| NCBI Official Synonym Symbols: | AIFL |
| NCBI Protein Information: | apoptosis-inducing factor 3; apoptosis-inducing factor like |
| UniProt Protein Name: | Apoptosis-inducing factor 3 |
| UniProt Synonym Protein Names: | Apoptosis-inducing factor-like protein |
| Protein Family: | Apoptosis-inducing factor |
| UniProt Gene Name: | AIFM3 |
| UniProt Entry Name: | AIFM3_HUMAN |
 | Western blot analysis of extracts of various cell lines, using AIFM3 antibody (CAB8597) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 90s. |
 | Immunohistochemistry of paraffin-embedded rat kidney using AIFM3 antibody (CAB8597) at dilution of 1:100 (40x lens). |
 | Immunohistochemistry of paraffin-embedded human liver cancer using AIFM3 antibody (CAB8597) at dilution of 1:100 (40x lens). |
 | Immunohistochemistry of paraffin-embedded mouse brain using AIFM3 antibody (CAB8597) at dilution of 1:100 (40x lens). |
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