Anti-AGPS Antibody (CAB10484)
- SKU:
- CAB10484
- Product type:
- Antibody
- Reactivity:
- Human
- Mouse
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Metabolism
Frequently bought together:
Description
| Antibody Name: | Anti-AGPS Antibody |
| Antibody SKU: | CAB10484 |
| Antibody Size: | 20uL, 50uL, 100uL |
| Application: | WB |
| Reactivity: | Human, Mouse |
| Host Species: | Rabbit |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 379-658 of human AGPS (NP_003650.1). |
| Application: | WB |
| Recommended Dilution: | WB 1:1000 - 1:2000 |
| Reactivity: | Human, Mouse |
| Positive Samples: | HL-60, HeLa, HepG2, K-562, Mouse kidney, Mouse lung |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 379-658 of human AGPS (NP_003650.1). |
| Purification Method: | Affinity purification |
| Storage Buffer: | Store at -20°C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| Isotype: | IgG |
| Sequence: | IKIR PVPE YQKY GSVA FPNF EQGV ACLR EIAK QRCA PASI RLMD NKQF QFGH ALKP QVSS IFTS FLDG LKKF YITK FKGF DPNQ LSVA TLLF EGDR EKVL QHEK QVYD IAAK FGGL AAGE DNGQ RGYL LTYV IAYI RDLA LEYY VLGE SFET SAPW DRVV DLCR NVKE RITR ECKE KGVQ FAPF STCR VTQT YDAG ACIY FYFA FNYR GISD PLTV FEQT EAAA REEI LANG GSLS HHHG VGKL RKQW LKES ISDV GFGM LKSV KEYV DPNN IFGN RNLL |
| Gene ID: | 8540 |
| Uniprot: | O00116 |
| Cellular Location: | Peroxisome membrane |
| Calculated MW: | 72kDa |
| Observed MW: | 60-73kDa |
| Synonyms: | AGPS, ADAP-S, ADAS, ADHAPS, ADPS, ALDHPSY, RCDP3 |
| Background: | This gene is a member of the FAD-binding oxidoreductase/transferase type 4 family. It encodes a protein that catalyzes the second step of ether lipid biosynthesis in which acyl-dihydroxyacetonephosphate (DHAP) is converted to alkyl-DHAP by the addition of a long chain alcohol and the removal of a long-chain acid anion. The protein is localized to the inner aspect of the peroxisomal membrane and requires FAD as a cofactor. Mutations in this gene have been associated with rhizomelic chondrodysplasia punctata, type 3 and Zellweger syndrome. |
| UniProt Protein Function: | AGPS: Defects in AGPS are the cause of rhizomelic chondrodysplasia punctata type 3 (RCDP3). RCDP3 is characterized by rhizomelic shortening of femur and humerus, vertebral disorders, cataract, cutaneous lesions and severe mental retardation. Belongs to the FAD-binding oxidoreductase/transferase type 4 family. |
| UniProt Protein Details: | Protein type:EC 2.5.1.26; Lipid Metabolism - ether lipid; Mitochondrial; Oxidoreductase; Transferase Chromosomal Location of Human Ortholog: 2q31.2 Cellular Component: membrane; mitochondrion; nucleolus; peroxisomal matrix; peroxisomal membrane; peroxisome Molecular Function:alkylglycerone-phosphate synthase activity; protein binding Biological Process: ether lipid biosynthetic process; lipid biosynthetic process Disease: Rhizomelic Chondrodysplasia Punctata, Type 3 |
| NCBI Summary: | This gene is a member of the FAD-binding oxidoreductase/transferase type 4 family. It encodes a protein that catalyzes the second step of ether lipid biosynthesis in which acyl-dihydroxyacetonephosphate (DHAP) is converted to alkyl-DHAP by the addition of a long chain alcohol and the removal of a long-chain acid anion. The protein is localized to the inner aspect of the peroxisomal membrane and requires FAD as a cofactor. Mutations in this gene have been associated with rhizomelic chondrodysplasia punctata, type 3 and Zellweger syndrome. [provided by RefSeq, Jul 2008] |
| UniProt Code: | O00116 |
| NCBI GenInfo Identifier: | 2498106 |
| NCBI Gene ID: | 8540 |
| NCBI Accession: | O00116.1 |
| UniProt Secondary Accession: | O00116,Q2TU35, A5D8U9, |
| UniProt Related Accession: | O00116 |
| Molecular Weight: | 73kDa |
| NCBI Full Name: | Alkyldihydroxyacetonephosphate synthase, peroxisomal |
| NCBI Synonym Full Names: | alkylglycerone phosphate synthase |
| NCBI Official Symbol: | AGPS |
| NCBI Official Synonym Symbols: | ADAS; ADPS; RCDP3; ADAP-S; ADHAPS; ALDHPSY |
| NCBI Protein Information: | alkyldihydroxyacetonephosphate synthase, peroxisomal |
| UniProt Protein Name: | Alkyldihydroxyacetonephosphate synthase, peroxisomal |
| UniProt Synonym Protein Names: | Aging-associated gene 5 protein; Alkylglycerone-phosphate synthase |
| Protein Family: | Alkyldihydroxyacetonephosphate synthase |
| UniProt Gene Name: | AGPS |
 | Western blot analysis of extracts of various cell lines, using AGPS antibody (CAB10484) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 5s. |
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