Anti-ADM Antibody (CAB8659)
- SKU:
- CAB8659
- Product type:
- Antibody
- Application:
- WB
- Reactivity:
- Human
- Mouse
- Host Species:
- Rabbit
- Isotype:
- IgG
- Research Area:
- Neuroscience
Frequently bought together:
Description
| Antibody Name: | Anti-ADM Antibody |
| Antibody SKU: | CAB8659 |
| Antibody Size: | 20uL, 50uL, 100uL |
| Application: | WB |
| Reactivity: | Mouse |
| Host Species: | Rabbit |
| Immunogen: | A synthetic peptide corresponding to a sequence within amino acids 50-150 of human ADM (NP_001115.1). |
| Application: | WB |
| Recommended Dilution: | WB 1:500 - 1:2000 |
| Reactivity: | Mouse |
| Positive Samples: | Mouse kidney |
| Immunogen: | A synthetic peptide corresponding to a sequence within amino acids 50-150 of human ADM (NP_001115.1). |
| Purification Method: | Affinity purification |
| Storage Buffer: | Store at -20°C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| Isotype: | IgG |
| Sequence: | SSYP TGLA DVKA GPAQ TLIR PQDM KGAS RSPE DSSP DAAR IRVK RYRQ SMNN FQGL RSFG CRFG TCTV QKLA HQIY QFTD KDKD NVAP RSKI SPQG YGRR R |
| Gene ID: | 133 |
| Uniprot: | P35318 |
| Cellular Location: | Secreted |
| Calculated MW: | 20kDa |
| Observed MW: | 20kDa |
| Synonyms: | ADM, AM, PAMP |
| Background: | The protein encoded by this gene is a preprohormone which is cleaved to form two biologically active peptides, adrenomedullin and proadrenomedullin N-terminal 20 peptide. Adrenomedullin is a 52 aa peptide with several functions, including vasodilation, regulation of hormone secretion, promotion of angiogenesis, and antimicrobial activity. The antimicrobial activity is antibacterial, as the peptide has been shown to kill E. coli and S. aureus at low concentration. |
| UniProt Protein Function: | ADM: AM and PAMP are potent hypotensive and vasodilatator agents. Numerous actions have been reported most related to the physiologic control of fluid and electrolyte homeostasis. In the kidney, am is diuretic and natriuretic, and both am and pamp inhibit aldosterone secretion by direct adrenal actions. In pituitary gland, both peptides at physiologically relevant doses inhibit basal ACTH secretion. Both peptides appear to act in brain and pituitary gland to facilitate the loss of plasma volume, actions which complement their hypotensive effects in blood vessels. Belongs to the adrenomedullin family. |
| UniProt Protein Details: | Protein type:Secreted, signal peptide; Secreted Chromosomal Location of Human Ortholog: 11p15.4 Cellular Component: cytoplasm; extracellular region; extracellular space Molecular Function:protein binding; receptor binding Biological Process: antibacterial humoral response; antifungal humoral response; blood circulation; cAMP biosynthetic process; cell-cell signaling; defense response to Gram-negative bacterium; defense response to Gram-positive bacterium; G-protein coupled receptor internalization; negative regulation of vasoconstriction; positive regulation of cAMP biosynthetic process; progesterone biosynthetic process; receptor internalization; response to yeast; signal transduction; vasculogenesis |
| NCBI Summary: | The protein encoded by this gene is a preprohormone which is cleaved to form two biologically active peptides, adrenomedullin and proadrenomedullin N-terminal 20 peptide. Adrenomedullin is a 52 aa peptide with several functions, including vasodilation, regulation of hormone secretion, promotion of angiogenesis, and antimicrobial activity. The antimicrobial activity is antibacterial, as the peptide has been shown to kill E. coli and S. aureus at low concentration. [provided by RefSeq, Aug 2014] |
| UniProt Code: | P35318 |
| NCBI GenInfo Identifier: | 461474 |
| NCBI Gene ID: | 133 |
| NCBI Accession: | P35318.1 |
| UniProt Secondary Accession: | P35318,Q6FGW2, B2R793, D3DQV3, |
| UniProt Related Accession: | P35318 |
| Molecular Weight: | 20,420 Da |
| NCBI Full Name: | ADM |
| NCBI Synonym Full Names: | adrenomedullin |
| NCBI Official Symbol: | ADM |
| NCBI Official Synonym Symbols: | AM; PAMP |
| NCBI Protein Information: | ADM |
| UniProt Protein Name: | ADM |
| UniProt Synonym Protein Names: | Adrenomedullin; AM |
| Protein Family: | ADM |
| UniProt Gene Name: | ADM |
| UniProt Entry Name: | ADML_HUMAN |
 | Western blot analysis of extracts of Mouse kidney, using ADM antibody (CAB8659) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 15s. |
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