Anti-ADAMTS7 Antibody (CAB17093)

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SKU:
CAB17093
Product type:
Antibody
Reactivity:
Human
Host Species:
Rabbit
Isotype:
IgG
Antibody Type:
Polyclonal Antibody
Frequently bought together:

Description

system_update_alt데이터시트system_update_alt안전 데이터시트
Antibody Name:Anti-ADAMTS7 Antibody
Antibody SKU:CAB17093
Antibody Size:20uL, 50uL, 100uL
Application:WB
Reactivity:Human
Host Species:Rabbit
Immunogen:A synthetic peptide corresponding to a sequence within amino acids 1600-1686 of human ADAMTS7 (NP_055087.2).
Application:WB
Recommended Dilution:WB 1:500 - 1:2000
Reactivity:Human
Positive Samples:SH-SY5Y
Immunogen:A synthetic peptide corresponding to a sequence within amino acids 1600-1686 of human ADAMTS7 (NP_055087.2).
Purification Method:Affinity purification
Storage Buffer:Store at -20°C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Isotype:IgG
Sequence:Email for sequence
Gene ID:11173
Uniprot:Q9UKP4
Cellular Location:
Calculated MW:
Observed MW:200kDa
Anti-ADAMTS7 Antibody (CAB17093)Western blot - ADAMTS7 Polyclonal Antibody (CAB17093)
Synonyms:ADAMTS7, ADAM-TS 7, ADAM-TS7, ADAMTS-7
Background:The protein encoded by this gene is a member of the ADAMTS (a disintegrin and metalloproteinase with thrombospondin motifs) family. Members of this family share several distinct protein modules, including a propeptide region, a metalloproteinase domain, a disintegrin-like domain, and a thrombospondin type 1 (TS) motif. Individual members of this family differ in the number of C-terminal TS motifs, and some have unique C-terminal domains. The encoded preproprotein is proteolytically processed to generate the mature enzyme. This enzyme contains two C-terminal TS motifs and may regulate vascular smooth muscle cell (VSMC) migration. Mutations in this gene may be associated with susceptibility to coronary artery disease.
UniProt Protein Function:ADAMTS7: Metalloprotease that may play a role in the degradation of COMP.
UniProt Protein Details:

Protein type:Cell surface; EC 3.4.24.-; Motility/polarity/chemotaxis; Protease; Secreted; Secreted, signal peptide

Chromosomal Location of Human Ortholog: 15q25.1

Cellular Component: endoplasmic reticulum lumen

Molecular Function:metalloendopeptidase activity; metallopeptidase activity; protein binding

Biological Process: negative regulation of chondrocyte differentiation; proteolysis involved in cellular protein catabolic process

NCBI Summary:The protein encoded by this gene is a member of the ADAMTS (a disintegrin and metalloproteinase with thrombospondin motifs) family. Members of this family share several distinct protein modules, including a propeptide region, a metalloproteinase domain, a disintegrin-like domain, and a thrombospondin type 1 (TS) motif. Individual members of this family differ in the number of C-terminal TS motifs, and some have unique C-terminal domains. The encoded preproprotein is proteolytically processed to generate the mature enzyme. This enzyme contains two C-terminal TS motifs and may regulate vascular smooth muscle cell (VSMC) migration. Mutations in this gene may be associated with susceptibility to coronary artery disease. [provided by RefSeq, Feb 2016]
UniProt Code:Q9UKP4
NCBI GenInfo Identifier:38683827
NCBI Gene ID:11173
NCBI Accession:NP_055087.2
UniProt Secondary Accession:Q9UKP4,Q14F51, Q6P7J9,
UniProt Related Accession:Q9UKP4
Molecular Weight:55.12kD
NCBI Full Name:A disintegrin and metalloproteinase with thrombospondin motifs 7 preproprotein
NCBI Synonym Full Names:ADAM metallopeptidase with thrombospondin type 1 motif 7
NCBI Official Symbol:ADAMTS7  
NCBI Official Synonym Symbols:ADAM-TS7; ADAMTS-7; ADAM-TS 7  
NCBI Protein Information:A disintegrin and metalloproteinase with thrombospondin motifs 7
UniProt Protein Name:A disintegrin and metalloproteinase with thrombospondin motifs 7
UniProt Synonym Protein Names:COMPase
Protein Family:A disintegrin and metalloproteinase with thrombospondin motifs
UniProt Gene Name:ADAMTS7  

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