Anti-ADAM19 Antibody (CAB10260)
- SKU:
- CAB10260
- Product type:
- Antibody
- Reactivity:
- Human
- Mouse
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Cell Biology
Frequently bought together:
Description
| Antibody Name: | Anti-ADAM19 Antibody |
| Antibody SKU: | CAB10260 |
| Antibody Size: | 20uL, 50uL, 100uL |
| Application: | WB IF |
| Reactivity: | Human, Mouse, Rat |
| Host Species: | Rabbit |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 203-460 of human ADAM19 (NP_150377.1). |
| Application: | WB IF |
| Recommended Dilution: | WB 1:1000 - 1:2000 IF 1:50 - 1:200 |
| Reactivity: | Human, Mouse, Rat |
| Positive Samples: | HT-1080, SW480, NIH/3T3, Mouse heart, Mouse lung, Mouse liver, Mouse kidney, Rat heart |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 203-460 of human ADAM19 (NP_150377.1). |
| Purification Method: | Affinity purification |
| Storage Buffer: | Store at -20°C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| Isotype: | IgG |
| Sequence: | REDL NSMK YVEL YLVA DYLE FQKN RRDQ DATK HKLI EIAN YVDK FYRS LNIR IALV GLEV WTHG NMCE VSEN PYST LWSF LSWR RKLL AQKY HDNA QLIT GMSF HGTT IGLA PLMA MCSV YQSG GVNM DHSE NAIG VAAT MAHE MGHN FGMT HDSA DCCS ASAA DGGC IMAA ATGH PFPK VFNG CNRR ELDR YLQS GGGM CLSN MPDT RMLY GGRR CGNG YLED GEEC DCGE EEEC NNPC CNAS NCTL RPGA ECAH GS |
| Gene ID: | 8728 |
| Uniprot: | Q9H013 |
| Cellular Location: | Membrane, Single-pass type I membrane protein |
| Calculated MW: | 100kDa/104kDa |
| Observed MW: | 72kDa |
| Synonyms: | ADAM19, FKSG34, MADDAM, MLTNB |
| Background: | This gene encodes a member of the ADAM (a disintegrin and metalloprotease domain) family. Members of this family are membrane-anchored proteins structurally related to snake venom disintegrins and have been implicated in a variety of biological processes involving cell-cell and cell-matrix interactions, including fertilization, muscle development, and neurogenesis. This member is a type I transmembrane protein and serves as a marker for dendritic cell differentiation. It has been demonstrated to be an active metalloproteinase, which may be involved in normal physiological processes such as cell migration, cell adhesion, cell-cell and cell-matrix interactions, and signal transduction. It is proposed to play a role in pathological processes, such as cancer, inflammatory diseases, renal diseases, and Alzheimer's disease. |
| UniProt Protein Function: | ADAM19: Participates in the proteolytic processing of beta-type neuregulin isoforms which are involved in neurogenesis and synaptogenesis, suggesting a regulatory role in glial cell. Also cleaves alpha-2 macroglobulin. May be involved in osteoblast differentiation and/or osteoblast activity in bone. 2 isoforms of the human protein are produced by alternative splicing. |
| UniProt Protein Details: | Protein type:EC 3.4.24.-; Motility/polarity/chemotaxis; Membrane protein, integral; Protease Chromosomal Location of Human Ortholog: 5q33.3 Cellular Component: integral to membrane Molecular Function:zinc ion binding; metalloendopeptidase activity; SH3 domain binding Biological Process: heart development; membrane protein ectodomain proteolysis |
| NCBI Summary: | This gene encodes a member of the ADAM (a disintegrin and metalloprotease domain) family. Members of this family are membrane-anchored proteins structurally related to snake venom disintegrins and have been implicated in a variety of biological processes involving cell-cell and cell-matrix interactions, including fertilization, muscle development, and neurogenesis. This member is a type I transmembrane protein and serves as a marker for dendritic cell differentiation. It has been demonstrated to be an active metalloproteinase, which may be involved in normal physiological processes such as cell migration, cell adhesion, cell-cell and cell-matrix interactions, and signal transduction. It is proposed to play a role in pathological processes, such as cancer, inflammatory diseases, renal diseases, and Alzheimer's disease. [provided by RefSeq, May 2013] |
| UniProt Code: | Q9H013 |
| NCBI GenInfo Identifier: | 302393821 |
| NCBI Gene ID: | 8728 |
| NCBI Accession: | Q9H013.3 |
| UniProt Secondary Accession: | Q9H013,Q9BZL5, Q9UHP2, |
| UniProt Related Accession: | Q9H013 |
| Molecular Weight: | 100,848 Da |
| NCBI Full Name: | Disintegrin and metalloproteinase domain-containing protein 19 |
| NCBI Synonym Full Names: | ADAM metallopeptidase domain 19 |
| NCBI Official Symbol: | ADAM19 |
| NCBI Official Synonym Symbols: | MLTNB; FKSG34; MADDAM |
| NCBI Protein Information: | disintegrin and metalloproteinase domain-containing protein 19; ADAM 19; meltrin-beta; metalloprotease-disintegrin meltrin beta; metalloprotease and disintegrin dendritic antigen marker; a disintegrin and metalloproteinase domain 19 (meltrin beta) |
| UniProt Protein Name: | Disintegrin and metalloproteinase domain-containing protein 19 |
| UniProt Synonym Protein Names: | Meltrin-beta; Metalloprotease and disintegrin dendritic antigen marker; MADDAM |
| Protein Family: | Disintegrin and metalloproteinase domain-containing protein |
| UniProt Gene Name: | ADAM19 |
| UniProt Entry Name: | ADA19_HUMAN |
 | Western blot analysis of extracts of various cell lines, using ADAM19 antibody (CAB10260) at 1:2000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 30s. |
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