Anti-ACSM2A Antibody (CAB15563)

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SKU:
CAB15563
Product type:
Antibody
Reactivity:
Mouse
Rat
Host Species:
Rabbit
Isotype:
IgG
Antibody Type:
Polyclonal Antibody
Research Area:
Metabolism
Frequently bought together:

Description

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Antibody Name:Anti-ACSM2A Antibody
Antibody SKU:CAB15563
Antibody Size:20uL, 50uL, 100uL
Application:WB
Reactivity:Mouse, Rat
Host Species:Rabbit
Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 418-577 of human ACSM2A (NP_001295101.1).
Application:WB
Recommended Dilution:WB 1:200 - 1:2000
Reactivity:Mouse, Rat
Positive Samples:Mouse kidney, Rat liver
Immunogen:Recombinant fusion protein containing a sequence corresponding to amino acids 418-577 of human ACSM2A (NP_001295101.1).
Purification Method:Affinity purification
Storage Buffer:Store at -20°C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Isotype:IgG
Sequence:RPIG IFSG YVDN PDKT AANI RGDF WLLG DRGI KDED GYFQ FMGR ANDI INSS GYRI GPSE VENA LMEH PAVV ETAV ISSP DPVR GEVV KAFV VLAS QFLS HDPE QLTK ELQQ HVKS VTAP YKYP RKIE FVLN LPKT VTGK IQRA KLRD KEWK MSGK ARAQ
Gene ID:123876
Uniprot:Q08AH3
Cellular Location:Mitochondrion matrix
Calculated MW:64kDa
Observed MW:64kDa
Synonyms:ACSM2A, A-923A4.1, ACSM2
Background:This gene encodes a mitochondrial acyl-coenzyme A synthetase that is specific for medium chain fatty acids. These enzymes catalyze fatty acid activation, the first step of fatty acid metabolism, through the transfer of acyl-CoA. These enzymes also participate in the glycine conjugation pathway in the detoxification of xenobiotics such as benzoate and ibuprofen. Expression levels of this gene in the kidney may be correlated with kidney function. This gene and its paralog ACSM2B (Gene ID: 348158), both present on chromosome 16, likely arose from a chromosomal duplication event.
UniProt Protein Function:ACSM2A: an acyl-CoA synthetase. Acyl-CoA synthetases catalyze the first reaction of amino acid conjugation in fatty acid metabolism and of many xenobiotic carboxylic acids. A liver enzyme implicated in the metabolism of xenobiotic carboxylic acids such as pesticides, arylpropionate anti-inflammatory drugs and hypolipidaemic clofibrate and its congeners.
UniProt Protein Details:

Protein type:Mitochondrial; Ligase; EC 6.2.1.2; Carbohydrate Metabolism - butanoate

Chromosomal Location of Human Ortholog: 16p12.3

Molecular Function:butyrate-CoA ligase activity

UniProt Code:Q08AH3
NCBI GenInfo Identifier:257050995
NCBI Gene ID:123876
NCBI Accession:Q08AH3.2
UniProt Secondary Accession:Q08AH3,O75202, B3KTT9,
UniProt Related Accession:Q08AH3
Molecular Weight:64,223 Da
NCBI Full Name:Acyl-coenzyme A synthetase ACSM2A, mitochondrial
NCBI Synonym Full Names:acyl-CoA synthetase medium-chain family member 2A
NCBI Official Symbol:ACSM2A  
NCBI Official Synonym Symbols:ACSM2; A-923A4.1  
NCBI Protein Information:acyl-coenzyme A synthetase ACSM2A, mitochondrial
UniProt Protein Name:Acyl-coenzyme A synthetase ACSM2A, mitochondrial
UniProt Synonym Protein Names:Acyl-CoA synthetase medium-chain family member 2A; Butyrate--CoA ligase 2A; Butyryl-coenzyme A synthetase 2A; Middle-chain acyl-CoA synthetase 2A
Protein Family:Acyl-coenzyme A synthetase
UniProt Gene Name:ACSM2A  
UniProt Entry Name:ACS2A_HUMAN
Anti-ACSM2A Antibody (CAB15563)Western blot analysis of extracts of various cell lines, using ACSM2A antibody (CAB15563) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 60s.

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