Anti-ACOX2 항체 (CAB12796)

Antibody Name:	Anti-ACOX2 Antibody
Antibody SKU:	CAB12796
Antibody Size:	20uL, 50uL, 100uL
Application:	WB IHC
Reactivity:	Human, Mouse
Host Species:	Rabbit
Immunogen:	Recombinant fusion protein containing a sequence corresponding to amino acids 1-150 of human ACOX2 (NP_003491.1).

Application:	WB IHC
Recommended Dilution:	WB 1:500 - 1:2000 IHC 1:50 - 1:200
Reactivity:	Human, Mouse
Positive Samples:	U-87MG, HT-29, Mouse liver

Immunogen:	Recombinant fusion protein containing a sequence corresponding to amino acids 1-150 of human ACOX2 (NP_003491.1).
Purification Method:	Affinity purification
Storage Buffer:	Store at -20°C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Isotype:	IgG
Sequence:	MGSP VHRV SLGD TWSR QMHP DIES ERYM QSFD VERL TNIL DGGA QNTA LRRK VESI IHSY PEFS CKDN YFMT QNER YKAA MRRA FHIR LIAR RLGW LEDG RELG YAYR ALSG DVAL NIHR VFVR ALRS LGSE EQIA KWDP LCKN IQII AT
Gene ID:	8309
Uniprot:	Q99424
Cellular Location:	Peroxisome
Calculated MW:	76kDa
Observed MW:	77kDa

Synonyms:

ACOX2, BCOX, BRCACOX, BRCOX, CBAS6, THCCox

Background:

The product of this gene belongs to the acyl-CoA oxidase family. It encodes the branched-chain acyl-CoA oxidase which is involved in the degradation of long branched fatty acids and bile acid intermediates in peroxisomes. Deficiency of this enzyme results in the accumulation of branched fatty acids and bile acid intermediates, and may lead to Zellweger syndrome, severe mental retardation, and death in children.

UniProt Protein Function:	ACOX2: Oxidizes the CoA esters of the bile acid intermediates di- and tri-hydroxycholestanoic acids. Belongs to the acyl-CoA oxidase family.
UniProt Protein Details:	Protein type:EC 1.17.99.3; Lipid Metabolism - primary bile acid biosynthesis; Oxidoreductase Chromosomal Location of Human Ortholog: 3p14.3 Cellular Component: intracellular membrane-bound organelle; mitochondrion; peroxisomal matrix; peroxisome Molecular Function:acyl-CoA binding; acyl-CoA dehydrogenase activity; acyl-CoA oxidase activity; electron carrier activity; FAD binding; pristanoyl-CoA oxidase activity; receptor binding Biological Process: bile acid biosynthetic process; fatty acid beta-oxidation using acyl-CoA dehydrogenase; fatty acid beta-oxidation using acyl-CoA oxidase; lipid homeostasis
NCBI Summary:	The product of this gene belongs to the acyl-CoA oxidase family. It encodes the branched-chain acyl-CoA oxidase which is involved in the degradation of long branched fatty acids and bile acid intermediates in peroxisomes. Deficiency of this enzyme results in the accumulation of branched fatty acids and bile acid intermediates, and may lead to Zellweger syndrome, severe mental retardation, and death in children. [provided by RefSeq, Mar 2009]
UniProt Code:	Q99424
NCBI GenInfo Identifier:	17366636
NCBI Gene ID:	8309
NCBI Accession:	Q99424.1
UniProt Secondary Accession:	Q99424,A6NF16, B2R8U5,
UniProt Related Accession:	Q99424
Molecular Weight:	76,827 Da
NCBI Full Name:	Peroxisomal acyl-coenzyme A oxidase 2
NCBI Synonym Full Names:	acyl-CoA oxidase 2
NCBI Official Symbol:	ACOX2
NCBI Official Synonym Symbols:	BCOX; BRCOX; THCCox; BRCACOX
NCBI Protein Information:	peroxisomal acyl-coenzyme A oxidase 2
UniProt Protein Name:	Peroxisomal acyl-coenzyme A oxidase 2
UniProt Synonym Protein Names:	3-alpha,7-alpha,12-alpha-trihydroxy-5-beta-cholestanoyl-CoA 24-hydroxylase; 3-alpha,7-alpha,12-alpha-trihydroxy-5-beta-cholestanoyl-CoA oxidase; Trihydroxycoprostanoyl-CoA oxidase; THCA-CoA oxidase; THCCox
Protein Family:	Peroxisomal acyl-coenzyme A oxidase
UniProt Gene Name:	ACOX2
UniProt Entry Name:	ACOX2_HUMAN

	Western blot analysis of extracts of various cell lines, using ACOX2 antibody (CAB12796) at 1:3000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 30s.
	Immunohistochemistry of paraffin-embedded human liver using ACOX2 antibody (CAB12796) at dilution of 1:100 (40x lens).

Antibodies

ACOX2 Antibody (PACO07565)

Secondary Antibody

Anti-HRP Goat Anti-Rabbit IgG (H+L) Antibody (CABS014)