Anti-ACC1 Antibody (CAB20183)
- SKU:
- CAB20183
- Product type:
- Antibody
- Antibody Type:
- Polyclonal Antibody
- Reactivity:
- Human
- Mouse
- Host Species:
- Rabbit
- Isotype:
- IgG
- Synonyms:
- ACC
- ACAC
- ACC1
- ACCA
- ACACAD
Description
Product Name: | ACC1 Rabbit pAb |
Product Code: | CAB20183 |
Size: | 50uL, 100uL |
Synonyms: | ACC, ACAC, ACC1, ACCA, ACACAD |
Applications: | WB |
Reactivity: | Human, Mouse |
Host Species: | Rabbit |
Immunogen: | Recombinant protein of human ACACA. |
Applications: | WB |
Recommended Dilutions: | WB 1:1000 - 1:2000 |
Reactivity: | Human, Mouse |
Positive Samples: | 293T, Mouse brain |
Immunogen: | Recombinant protein of human ACACA. |
Purification Method: | Affinity purification |
Storage: | Store at -20°C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
Isotype: | IgG |
Sequence: | Email for sequence |
Gene ID: | 31 |
Uniprot: | Q13085 |
Calculated MW: | 265kDa |
Observed MW: | 266KDa |
UniProt Protein Function: | ACC1: a subunit of acetyl-CoA carboxylase (ACC), a multifunctional enzyme system. Catalyzes the carboxylation of acetyl-CoA to malonyl-CoA, the rate-limiting step in fatty acid synthesis. Phosphorylation by AMPK or PKA inhibits the enzymatic activity of ACC. ACC-alpha is the predominant isoform in liver, adipocyte and mammary gland. ACC-beta is the major isoform in skeletal muscle and heart. Phosphorylation regulates its activity. |
UniProt Protein Details: | Protein type:Carbohydrate Metabolism - propanoate; Carbohydrate Metabolism - pyruvate; Ligase; EC 6.4.1.2; EC 6.3.4.14; Lipid Metabolism - fatty acid biosynthesis Chromosomal Location of Human Ortholog: 17q21 Cellular Component: actin cytoskeleton; cytoplasm; cytosol; mitochondrion; nucleolus Molecular Function:acetyl-CoA carboxylase activity; ATP binding; biotin carboxylase activity; metal ion binding; protein binding Biological Process: acetyl-CoA metabolic process; biotin metabolic process; carnitine shuttle; cellular lipid metabolic process; energy reserve metabolic process; fatty acid biosynthetic process; lipid homeostasis; multicellular organismal protein metabolic process; positive regulation of cellular metabolic process; protein homotetramerization; tissue homeostasis; triacylglycerol biosynthetic process; vitamin metabolic process; water-soluble vitamin metabolic process Disease: Acetyl-coa Carboxylase Deficiency |
NCBI Summary: | Acetyl-CoA carboxylase (ACC) is a complex multifunctional enzyme system. ACC is a biotin-containing enzyme which catalyzes the carboxylation of acetyl-CoA to malonyl-CoA, the rate-limiting step in fatty acid synthesis. There are two ACC forms, alpha and beta, encoded by two different genes. ACC-alpha is highly enriched in lipogenic tissues. The enzyme is under long term control at the transcriptional and translational levels and under short term regulation by the phosphorylation/dephosphorylation of targeted serine residues and by allosteric transformation by citrate or palmitoyl-CoA. Multiple alternatively spliced transcript variants divergent in the 5' sequence and encoding distinct isoforms have been found for this gene. [provided by RefSeq, Jul 2008] |
UniProt Code: | Q13085 |
NCBI GenInfo Identifier: | 118601083 |
NCBI Gene ID: | 31 |
NCBI Accession: | Q13085.2 |
UniProt Secondary Accession: | Q13085,Q6KEV6, Q6XDA8, Q7Z2G8, Q7Z561, Q7Z563, Q7Z564 Q86WB2, Q86WB3, B2RP68, |
UniProt Related Accession: | Q13085 |
Molecular Weight: | 269,999 Da |
NCBI Full Name: | Acetyl-CoA carboxylase 1 |
NCBI Synonym Full Names: | acetyl-CoA carboxylase alpha |
NCBI Official Symbol: | ACACA |
NCBI Official Synonym Symbols: | ACC; ACAC; ACC1; ACCA; ACACAD |
NCBI Protein Information: | acetyl-CoA carboxylase 1 |
UniProt Protein Name: | Acetyl-CoA carboxylase 1 |
UniProt Synonym Protein Names: | ACC-alphaIncluding the following 1 domains:Biotin carboxylase (EC:6.3.4.14 |
UniProt Gene Name: | ACACA |
UniProt Entry Name: | ACACA_HUMAN |