Anti-ABCD4 Antibody (CAB17523)
- SKU:
- CAB17523
- Product type:
- Antibody
- Reactivity:
- Human
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
Frequently bought together:
Description
| Antibody Name: | Anti-ABCD4 Antibody |
| Antibody SKU: | CAB17523 |
| Antibody Size: | 20uL, 50uL, 100uL |
| Application: | WB |
| Reactivity: | Human |
| Host Species: | Rabbit |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 100-280 of human ABCD4 (NP_005041.1). |
| Application: | WB |
| Recommended Dilution: | WB 1:500 - 1:2000 |
| Reactivity: | Human |
| Positive Samples: | MCF7 |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 100-280 of human ABCD4 (NP_005041.1). |
| Purification Method: | Affinity purification |
| Storage Buffer: | Store at -20°C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| Isotype: | IgG |
| Sequence: | DQFT CNLL YVSW RKDL TEHL HRLY FRGR AYYT LNVL RDDI DNPD QRIS QDVE RFCR QLSS MASK LIIS PFTL VYYT YQCF QSTG WLGP VSIF GYFI LGTV VNKT LMGP IVMK LVHQ EKLE GDFR FKHM QIRV NAEP AAFY RAGH VEHM RTDR RLQR LLQT QREL MSKE LWLY IGIN TFDY L |
| Gene ID: | 5826 |
| Uniprot: | O14678 |
| Cellular Location: | |
| Calculated MW: | |
| Observed MW: | 72kDa |
 | Western blot - ABCD4 Polyclonal Antibody (CAB17523) |
| Synonyms: | ABC41, EST352188, MAHCJ, P70R, P79R, PMP69, PXMP1L, ABCD4 |
| Background: | The protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the ALD subfamily, which is involved in peroxisomal import of fatty acids and/or fatty acyl-CoAs in the organelle. All known peroxisomal ABC transporters are half transporters which require a partner half transporter molecule to form a functional homodimeric or heterodimeric transporter. The function of this peroxisomal membrane protein is unknown. However, it is speculated that it may function as a heterodimer for another peroxisomal ABC transporter and, therefore, may modify the adrenoleukodystrophy phenotype. It may also play a role in the process of peroxisome biogenesis. Alternative splicing results in at least two different transcript variants, one which is protein-coding and one which is probably not protein-coding. [provided by RefSeq, Jul 2008] |
| UniProt Protein Function: | ABCD4: is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the ALD subfamily, which is involved in peroxisomal import of fatty acids and/or fatty acyl-CoAs in the organelle. All known peroxisomal ABC transporters are half transporters which require a partner half transporter molecule to form a functional homodimeric or heterodimeric transporter. The function of this peroxisomal membrane protein is unknown. However, it is speculated that it may function as a heterodimer for another peroxisomal ABC transporter and, therefore, may modify the adrenoleukodystrophy phenotype. It may also play a role in the process of peroxisome biogenesis. Alternative splicing results in at least two different transcript variants, one which is protein-coding and one which is probably not protein-coding. [provided by RefSeq, Jul 2008] |
| UniProt Protein Details: | Protein type:Transporter; Membrane protein, integral; Membrane protein, multi-pass; Transporter, ABC family Chromosomal Location of Human Ortholog: 14q24.3 Cellular Component: peroxisomal membrane; endoplasmic reticulum membrane; lysosomal membrane; integral to membrane; peroxisome; ATP-binding cassette (ABC) transporter complex Molecular Function:ATPase activity, coupled to transmembrane movement of substances; ATP binding Biological Process: vitamin metabolic process; cobalamin metabolic process; transmembrane transport; water-soluble vitamin metabolic process Disease: Methylmalonic Aciduria And Homocystinuria, Cblj Type |
| NCBI Summary: | The protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the ALD subfamily, which is involved in peroxisomal import of fatty acids and/or fatty acyl-CoAs in the organelle. All known peroxisomal ABC transporters are half transporters which require a partner half transporter molecule to form a functional homodimeric or heterodimeric transporter. The function of this peroxisomal membrane protein is unknown. However, it is speculated that it may function as a heterodimer for another peroxisomal ABC transporter and, therefore, may modify the adrenoleukodystrophy phenotype. It may also play a role in the process of peroxisome biogenesis. Alternative splicing results in at least two different transcript variants, one which is protein-coding and one which is probably not protein-coding. [provided by RefSeq, Jul 2008] |
| UniProt Code: | O14678 |
| NCBI GenInfo Identifier: | 4826958 |
| NCBI Gene ID: | 5826 |
| NCBI Accession: | NP_005041.1 |
| UniProt Secondary Accession: | O14678,Q6IAQ0, Q96E75, A8K5L7, |
| UniProt Related Accession: | O14678 |
| Molecular Weight: | 68,597 Da |
| NCBI Full Name: | ATP-binding cassette sub-family D member 4 |
| NCBI Synonym Full Names: | ATP-binding cassette, sub-family D (ALD), member 4 |
| NCBI Official Symbol: | ABCD4 |
| NCBI Official Synonym Symbols: | P70R; P79R; ABC41; MAHCJ; PMP69; PXMP1L; EST352188 |
| NCBI Protein Information: | ATP-binding cassette sub-family D member 4; PXMP1-L; PMP70-related protein; peroxisomal membrane protein 69; 69 kDa peroxisomal ABC-transporter |
| UniProt Protein Name: | ATP-binding cassette sub-family D member 4 |
| UniProt Synonym Protein Names: | PMP70-related protein; P70R; Peroxisomal membrane protein 1-like; PXMP1-L; Peroxisomal membrane protein 69; PMP69 |
| Protein Family: | ATP-binding cassette sub-family |
| UniProt Gene Name: | ABCD4 |
| UniProt Entry Name: | ABCD4_HUMAN |
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