Anti-AARS2 Antibody (CAB7826)
- SKU:
- CAB7826
- Product type:
- Antibody
- Reactivity:
- Human
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
- Research Area:
- Metabolism
Frequently bought together:
Description
| Antibody Name: | Anti-AARS2 Antibody |
| Antibody SKU: | CAB7826 |
| Antibody Size: | 20uL, 50uL, 100uL |
| Application: | WB IHC |
| Reactivity: | Human |
| Host Species: | Rabbit |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 841-985 of human AARS2 (NP_065796.1). |
| Application: | WB IHC |
| Recommended Dilution: | WB 1:500 - 1:2000 IHC 1:50 - 1:200 |
| Reactivity: | Human |
| Positive Samples: | HepG2, SKOV3, U-251MG, MCF7 |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 841-985 of human AARS2 (NP_065796.1). |
| Purification Method: | Affinity purification |
| Storage Buffer: | Store at -20°C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| Isotype: | IgG |
| Sequence: | RREL LATV KMLQ RRAN TAIR KLQM GQAA KKTQ ELLE RHSK GPLI VDTV SAES LSVL VKVV RQLC EQAP STSV LLLS PQPM GKVL CACQ VAQG AMPT FTAE AWAL AVCS HMGG KAWG SRVV AQGT GSTT DLEA ALSI AQTY ALSQ L |
| Gene ID: | 57505 |
| Uniprot: | Q5JTZ9 |
| Cellular Location: | Mitochondrion |
| Calculated MW: | 107kDa |
| Observed MW: | 107kDa |
| Synonyms: | AARS2, AARSL, COXPD8, LKENP, MT-ALARS, MTALARS |
| Background: | The protein encoded by this gene belongs to the class-II aminoacyl-tRNA synthetase family. Aminoacyl-tRNA synthetases play critical roles in mRNA translation by charging tRNAs with their cognate amino acids. The encoded protein is a mitochondrial enzyme that specifically aminoacylates alanyl-tRNA. Mutations in this gene are a cause of combined oxidative phosphorylation deficiency 8. |
| NCBI Summary: | The protein encoded by this gene belongs to the class-II aminoacyl-tRNA synthetase family. Aminoacyl-tRNA synthetases play critical roles in mRNA translation by charging tRNAs with their cognate amino acids. The encoded protein is a mitochondrial enzyme that specifically aminoacylates alanyl-tRNA. Mutations in this gene are a cause of combined oxidative phosphorylation deficiency 8. [provided by RefSeq, Dec 2011] |
| UniProt Code: | Q5JTZ9 |
| NCBI GenInfo Identifier: | 38569417 |
| NCBI Gene ID: | 57505 |
| NCBI Accession: | NP_065796.1 |
| UniProt Related Accession: | Q5JTZ9 |
| Molecular Weight: | 108 kDa |
| NCBI Full Name: | alanine--tRNA ligase, mitochondrial |
| NCBI Synonym Full Names: | alanyl-tRNA synthetase 2, mitochondrial |
| NCBI Official Symbol: | AARS2 |
| NCBI Official Synonym Symbols: | AARSL; LKENP; COXPD8; MTALARS; MT-ALARS |
| NCBI Protein Information: | alanine--tRNA ligase, mitochondrial |
| UniProt Protein Name: | Alanine--tRNA ligase, mitochondrial |
| UniProt Synonym Protein Names: | Alanyl-tRNA synthetase; AlaRS |
| UniProt Gene Name: | AARS2 |
| UniProt Entry Name: | SYAM_HUMAN |
 | Western blot analysis of extracts of various cell lines, using AARS2 antibody (CAB7826) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (CABS014) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit (RM00020). Exposure time: 20s. |
 | Immunohistochemistry of paraffin-embedded human liver damage using AARS2 antibody (CAB7826) at dilution of 1:100 (40x lens). |
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