Anti-A2ML1 Antibody (CAB17831)
- SKU:
- CAB17831
- Product type:
- Antibody
- Reactivity:
- Human
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Antibody Type:
- Polyclonal Antibody
Frequently bought together:
Description
| Antibody Name: | Anti-A2ML1 Antibody |
| Antibody SKU: | CAB17831 |
| Antibody Size: | 20uL, 50uL, 100uL |
| Application: | WB |
| Reactivity: | Human, Rat |
| Host Species: | Rabbit |
| Immunogen: | A synthetic peptide of Human A2ML1. |
| Application: | WB |
| Recommended Dilution: | WB 1:500 - 1:2000 |
| Reactivity: | Human, Rat |
| Positive Samples: | HeLa |
| Immunogen: | A synthetic peptide of Human A2ML1. |
| Purification Method: | Affinity purification |
| Storage Buffer: | Store at -20°C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| Isotype: | IgG |
| Sequence: | Email for sequence |
| Gene ID: | 144568 |
| Uniprot: | A8K2U0 |
| Cellular Location: | |
| Calculated MW: | |
| Observed MW: | 161kDa |
 | Western blot - A2ML1 Rabbit pAb (CAB17831) |
| Synonyms: | CPAMD9, p170, A2ML1 |
| Background: | This gene encodes a member of the alpha-macroglobulin superfamily. The encoded protein is thought to be an N-glycosylated monomeric protein that acts as an inhibitor of several proteases. It has been shown to form covalent interactions with proteases, and has been reported as the p170 antigen recognized by autoantibodies in the autoimmune disease paraneoplastic pemphigus (PNP; PMID:20805888). Mutations in these gene have also been associated with some cases of Noonan syndrome (NS; PMID:24939586) as well as some cases of otitis media (PMID:26121085). Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Aug 2015] |
| UniProt Protein Function: | A2ML1: Is able to inhibit all four classes of proteinases by a unique 'trapping' mechanism. This protein has a peptide stretch, called the 'bait region' which contains specific cleavage sites for different proteinases. When a proteinase cleaves the bait region, a conformational change is induced in the protein which traps the proteinase. The entrapped enzyme remains active against low molecular weight substrates (activity against high molecular weight substrates is greatly reduced). Following cleavage in the bait region a thioester bond is hydrolyzed and mediates the covalent binding of the protein to the proteinase. Displays inhibitory activity against chymotrypsin, papain, thermolysin, subtilisin A and, to a lesser extent, elastase but not trypsin. May play an important role during desquamation by inhibiting extracellular proteases. Belongs to the protease inhibitor I39 (alpha-2- macroglobulin) family. |
| UniProt Protein Details: | Protein type:Secreted, signal peptide; Secreted; Inhibitor Chromosomal Location of Human Ortholog: 12p13.31 Cellular Component: extracellular space Molecular Function:protease inhibitor activity Biological Process: regulation of endopeptidase activity |
| NCBI Summary: | This gene encodes a member of the alpha-macroglobulin superfamily. The encoded protein is thought to be an N-glycosylated monomeric protein that acts as an inhibitor of several proteases. It has been shown to form covalent interactions with proteases, and has been reported as the p170 antigen recognized by autoantibodies in the autoimmune disease paraneoplastic pemphigus (PNP; PMID:20805888). Mutations in these gene have also been associated with some cases of Noonan syndrome (NS; PMID:24939586) as well as some cases of otitis media (PMID:26121085). Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Aug 2015] |
| UniProt Code: | A8K2U0 |
| NCBI GenInfo Identifier: | 308153641 |
| NCBI Gene ID: | 144568 |
| NCBI Accession: | A8K2U0.3 |
| UniProt Secondary Accession: | A8K2U0,Q2M224, Q6ZW52, Q6ZW53, Q8N1M4, Q96LQ8, B5MDD1 B7Z7V4, D3DUV3, F5H2Z2, |
| UniProt Related Accession: | A8K2U0 |
| Molecular Weight: | 105,968 Da |
| NCBI Full Name: | Alpha-2-macroglobulin-like protein 1 |
| NCBI Synonym Full Names: | alpha-2-macroglobulin like 1 |
| NCBI Official Symbol: | A2ML1 |
| NCBI Official Synonym Symbols: | CPAMD9 |
| NCBI Protein Information: | alpha-2-macroglobulin-like protein 1 |
| UniProt Protein Name: | Alpha-2-macroglobulin-like protein 1 |
| UniProt Synonym Protein Names: | C3 and PZP-like alpha-2-macroglobulin domain-containing protein 9 |
| Protein Family: | Alpha-2-macroglobulin-like protein |
| UniProt Gene Name: | A2ML1 |
| UniProt Entry Name: | A2ML1_HUMAN |
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