Anti-67kDa Laminin Receptor Antibody (CAB5968)

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SKU:
CAB5968
Product type:
Antibody
Antibody Type:
Monoclonal Antibody
Reactivity:
Human
Mouse
Rat
Host Species:
Rabbit
Isotype:
IgG
Synonyms:
37LRP
67LR
ICAS
LAMBR
LAMR1
LBP
LBP/p40
LRP
LRP/LR
NEM/1CHD4
SA
lamR
p40
Frequently bought together:

Description

Product Name:67kDa Laminin Receptor Rabbit mAb
Product Code:CAB5968
Size:20uL, 50uL, 100uL
Synonyms:37LRP, 67LR, ICAS, LAMBR, LAMR1, LBP, LBP/p40, LRP, LRP/LR, NEM/1CHD4, SA, lamR, p40
Applications:WB, IF
Reactivity:Human, Mouse, Rat
Host Species:Rabbit
Immunogen:A synthesized peptide derived from human 67kDa Laminin Receptor
Applications:WB, IF
Recommended Dilutions:WB 1:500 - 1:2000 IF 1:50 - 1:200
Reactivity:Human, Mouse, Rat
Positive Samples:PC-12, A-549, BxPC-3, Raji, RAW264.7, Rat pancreas
Immunogen:A synthesized peptide derived from human 67kDa Laminin Receptor
Purification Method:Affinity purification
Storage:Store at -20°C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 0.05% BSA, 50% glycerol, pH7.3.
Isotype:IgG
Sequence:Email for sequence
Gene ID:3921
Uniprot:P08865
Calculated MW:42kDa
Observed MW:45KDa
UniProt Protein Function:RPSA: Required for the assembly and/or stability of the 40S ribosomal subunit. Required for the processing of the 20S rRNA- precursor to mature 18S rRNA in a late step of the maturation of 40S ribosomal subunits. Also functions as a cell surface receptor for laminin. Plays a role in cell adhesion to the basement membrane and in the consequent activation of signaling transduction pathways. May play a role in cell fate determination and tissue morphogenesis. Acts as a PPP1R16B-dependent substrate of PPP1CA. Also acts as a receptor for several other ligands, including the pathogenic prion protein, viruses, and bacteria. Belongs to the ribosomal protein S2P family.
UniProt Protein Details:

Protein type:Ribosomal

Chromosomal Location of Human Ortholog: 3p22.2

Cellular Component: cytoplasm; cytosol; membrane; nucleus; plasma membrane

Molecular Function:laminin binding; laminin receptor activity; protein binding; ribosome binding; structural constituent of ribosome; viral receptor activity

Biological Process: cell adhesion; cellular protein metabolic process; endonucleolytic cleavage in ITS1 to separate SSU-rRNA from 5.8S rRNA and LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA); endonucleolytic cleavage to generate mature 3'-end of SSU-rRNA from (SSU-rRNA, 5.8S rRNA, LSU-rRNA); entry of virus into host cell; gene expression; mRNA catabolic process, nonsense-mediated decay; ribosomal small subunit assembly and maintenance; rRNA export from nucleus; selenium metabolic process; selenocysteine metabolic process; SRP-dependent cotranslational protein targeting to membrane; translation; translational elongation; translational initiation; translational termination; viral infectious cycle; viral reproduction; viral transcription

Disease: Asplenia, Isolated Congenital

NCBI Summary:Laminins, a family of extracellular matrix glycoproteins, are the major noncollagenous constituent of basement membranes. They have been implicated in a wide variety of biological processes including cell adhesion, differentiation, migration, signaling, neurite outgrowth and metastasis. Many of the effects of laminin are mediated through interactions with cell surface receptors. These receptors include members of the integrin family, as well as non-integrin laminin-binding proteins. This gene encodes a high-affinity, non-integrin family, laminin receptor 1. This receptor has been variously called 67 kD laminin receptor, 37 kD laminin receptor precursor (37LRP) and p40 ribosome-associated protein. The amino acid sequence of laminin receptor 1 is highly conserved through evolution, suggesting a key biological function. It has been observed that the level of the laminin receptor transcript is higher in colon carcinoma tissue and lung cancer cell line than their normal counterparts. Also, there is a correlation between the upregulation of this polypeptide in cancer cells and their invasive and metastatic phenotype. Multiple copies of this gene exist, however, most of them are pseudogenes thought to have arisen from retropositional events. Two alternatively spliced transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Jul 2008]
UniProt Code:P08865
NCBI GenInfo Identifier:125969
NCBI Gene ID:3921
NCBI Accession:P08865.4
UniProt Secondary Accession:P08865,P11085, P12030, Q16471, Q6IPD1, Q6IPD2, Q6NSD1 Q6NXQ8, Q86VC0,
UniProt Related Accession:P08865
Molecular Weight:
NCBI Full Name:40S ribosomal protein SA
NCBI Synonym Full Names:ribosomal protein SA
NCBI Official Symbol:RPSA  
NCBI Official Synonym Symbols:SA; LBP; LRP; p40; 67LR; ICAS; lamR; 37LRP; LAMBR; LAMR1; LRP/LR; LBP/p40; NEM/1CHD4  
NCBI Protein Information:40S ribosomal protein SA
UniProt Protein Name:40S ribosomal protein SA
UniProt Synonym Protein Names:37 kDa laminin receptor precursor
Protein Family:30S ribosomal protein
UniProt Gene Name:RPSA  
UniProt Entry Name:RSSA_HUMAN

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