Anti-4-1BBL/CD137L Antibody (CAB3386)

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SKU:
CAB3386
Product type:
Antibody
Antibody Type:
Monoclonal Antibody
Reactivity:
Human
Reactivity:
Mouse
Reactivity:
Rat
Host Species:
Rabbit
Isotype:
IgG
Synonyms:
4-1BB-L
Synonyms:
CD137L
Synonyms:
TNLG5A
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Description

Product Name:4-1BBL/CD137L Rabbit mAb
Product Code:CAB3386
Size:20uL, 50uL, 100uL
Synonyms:4-1BB-L, CD137L, TNLG5A
Applications:WB
Reactivity:Human, Mouse, Rat
Host Species:Rabbit
Immunogen:A synthesized peptide derived from human 4-1BBL/CD137L
Applications:WB
Recommended Dilutions:WB 1:500 - 1:2000
Reactivity:Human, Mouse, Rat
Positive Samples:HeLa, Raji, SH-SY5Y, Mouse lung, Mouse brain, Rat lung
Immunogen:A synthesized peptide derived from human 4-1BBL/CD137L
Purification Method:Affinity purification
Storage:Store at -20°C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 0.05% BSA, 50% glycerol, pH7.3.
Isotype:IgG
Sequence:Email for sequence
Gene ID:8744
Uniprot:P41273
Cellular Location:Membrane, Single-pass type II membrane protein
Calculated MW:25-32kDa
Observed MW:27kDa
UniProt Protein Function:TNFL9: Cytokine that binds to TNFRSF9. Induces the proliferation of activated peripheral blood T-cells. May have a role in activation-induced cell death (AICD). May play a role in cognate interactions between T-cells and B-cells/macrophages. Belongs to the tumor necrosis factor family.
UniProt Protein Details:

Protein type:Apoptosis; Cell cycle regulation; Cytokine; Membrane protein, integral

Chromosomal Location of Human Ortholog: 19p13.3

Cellular Component: plasma membrane

Molecular Function:receptor binding; tumor necrosis factor receptor superfamily binding

Biological Process: apoptosis; cell proliferation; cell-cell signaling; positive regulation of activated T cell proliferation; positive regulation of cytotoxic T cell differentiation; signal transduction; tumor necrosis factor-mediated signaling pathway

NCBI Summary:The protein encoded by this gene is a cytokine that belongs to the tumor necrosis factor (TNF) ligand family. This transmembrane cytokine is a bidirectional signal transducer that acts as a ligand for TNFRSF9/4-1BB, which is a costimulatory receptor molecule in T lymphocytes. This cytokine and its receptor are involved in the antigen presentation process and in the generation of cytotoxic T cells. The receptor TNFRSF9/4-1BB is absent from resting T lymphocytes but rapidly expressed upon antigenic stimulation. The ligand encoded by this gene, TNFSF9/4-1BBL, has been shown to reactivate anergic T lymphocytes in addition to promoting T lymphocyte proliferation. This cytokine has also been shown to be required for the optimal CD8 responses in CD8 T cells. This cytokine is expressed in carcinoma cell lines, and is thought to be involved in T cell-tumor cell interaction.[provided by RefSeq, Oct 2008]
UniProt Code:P41273
NCBI GenInfo Identifier:728739
NCBI Gene ID:8744
NCBI Accession:P41273.1
UniProt Secondary Accession:P41273,Q2M3S2,
UniProt Related Accession:P41273
Molecular Weight:27kDa
NCBI Full Name:Tumor necrosis factor ligand superfamily member 9
NCBI Synonym Full Names:TNF superfamily member 9
NCBI Official Symbol:TNFSF9  
NCBI Official Synonym Symbols:CD137L; TNLG5A; 4-1BB-L  
NCBI Protein Information:tumor necrosis factor ligand superfamily member 9
UniProt Protein Name:Tumor necrosis factor ligand superfamily member 9
UniProt Synonym Protein Names:4-1BB ligand; 4-1BBL
Protein Family:Tumor necrosis factor ligand superfamily
UniProt Gene Name:TNFSF9  
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