Anti-14-3-3 sigma Antibody (CAB4377)
- SKU:
- CAB4377
- Product type:
- Antibody
- Antibody Type:
- Monoclonal Antibody
- Reactivity:
- Human
- Mouse
- Host Species:
- Rabbit
- Isotype:
- IgG
- Synonyms:
- YWHAS
Description
| Product Name: | 14-3-3 sigma Rabbit mAb |
| Product Code: | CAB4377 |
| Size: | 20uL, 50uL, 100uL |
| Synonyms: | YWHAS |
| Applications: | WB, IHC |
| Reactivity: | Human, Mouse |
| Host Species: | Rabbit |
| Immunogen: | A synthesized peptide derived from human 14-3-3 sigma |
| Applications: | WB, IHC |
| Recommended Dilutions: | WB 1:500 - 1:2000 IHC 1:50 - 1:200 |
| Reactivity: | Human, Mouse |
| Positive Samples: | A-431, Mouse lung, Mouse kidney |
| Immunogen: | A synthesized peptide derived from human 14-3-3 sigma |
| Purification Method: | Affinity purification |
| Storage: | Store at -20°C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 0.05% BSA, 50% glycerol, pH7.3. |
| Isotype: | IgG |
| Sequence: | Email for sequence |
| Gene ID: | 2810 |
| Uniprot: | P31947 |
| Calculated MW: | 28kDa |
| Observed MW: | 29KDa |
| UniProt Protein Function: | 14-3-3 sigma: Adapter protein implicated in the regulation of a large spectrum of both general and specialized signaling pathways. Binds to a large number of partners, usually by recognition of a phosphoserine or phosphothreonine motif. Binding generally results in the modulation of the activity of the binding partner. When bound to KRT17, regulates protein synthesis and epithelial cell growth by stimulating Akt/mTOR pathway. Homodimer. Interacts with KRT17 and SAMSN1. Found in a complex with XPO7, EIF4A1, ARHGAP1, VPS26A, VPS29, VPS35 and SFN. Interacts with GAB2. Interacts with SRPK2. Present mainly in tissues enriched in stratified squamous keratinizing epithelium. Belongs to the 14-3-3 family. 2 isoforms of the human protein are produced by alternative splicing. |
| UniProt Protein Details: | Protein type:Adaptor/scaffold Chromosomal Location of Human Ortholog: 1p36.11 Cellular Component: extracellular space; cytoplasmic vesicle membrane; cytoplasm; cytosol; nucleus Molecular Function:protein domain specific binding; protein kinase C inhibitor activity; protein binding; phosphoprotein binding; protein kinase binding Biological Process: positive regulation of protein export from nucleus; regulation of epidermal cell division; release of cytochrome c from mitochondria; DNA damage response, signal transduction resulting in induction of apoptosis; apoptosis; keratinization; positive regulation of epidermal cell differentiation; negative regulation of protein kinase activity; negative regulation of caspase activity; regulation of cyclin-dependent protein kinase activity; signal transduction; positive regulation of cell growth |
| UniProt Code: | P31947 |
| NCBI GenInfo Identifier: | 398953 |
| NCBI Gene ID: | 2810 |
| NCBI Accession: | P31947.1 |
| UniProt Secondary Accession: | P31947,Q6FH30, Q6FH51, Q96DH0, |
| UniProt Related Accession: | P31947 |
| Molecular Weight: | 24,336 Da |
| NCBI Full Name: | 14-3-3 protein sigma |
| NCBI Synonym Full Names: | stratifin |
| NCBI Official Symbol: | SFN |
| NCBI Official Synonym Symbols: | YWHAS |
| NCBI Protein Information: | 14-3-3 protein sigma; 14-3-3 sigma; epithelial cell marker protein 1 |
| UniProt Protein Name: | 14-3-3 protein sigma |
| UniProt Synonym Protein Names: | Epithelial cell marker protein 1; Stratifin |
| Protein Family: | 14-3-3 protein |
| UniProt Gene Name: | SFN |
| UniProt Entry Name: | 1433S_HUMAN |
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