Anti-14-3-3 epsilon Antibody (CAB4933)

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SKU:
CAB4933
Product type:
Antibody
Antibody Type:
Monoclonal Antibody
Reactivity:
Human
Mouse
Rat
Host Species:
Rabbit
Isotype:
IgG
Synonyms:
14-3-3E
HEL2
KCIP-1
MDCR
MDS
Frequently bought together:

Description

Product Name:14-3-3 epsilon Rabbit mAb
Product Code:CAB4933
Size:20uL, 50uL, 100uL
Synonyms:14-3-3E, HEL2, KCIP-1, MDCR, MDS
Applications:WB
Reactivity:Human, Mouse, Rat
Host Species:Rabbit
Immunogen:A synthesized peptide derived from human 14-3-3 epsilon
Applications:WB
Recommended Dilutions:WB 1:500 - 1:2000
Reactivity:Human, Mouse, Rat
Positive Samples:HeLa, Mouse brain, Mouse kidney, Rat lung, Rat brain
Immunogen:A synthesized peptide derived from human 14-3-3 epsilon
Purification Method:Affinity purification
Storage:Store at -20°C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 0.05% BSA, 50% glycerol, pH7.3.
Isotype:IgG
Sequence:Email for sequence
Gene ID:7531
Uniprot:P62258
Cellular Location:Cytoplasm, Melanosome
Calculated MW:29kDa
Observed MW:28KDa
UniProt Protein Function:Adapter protein implicated in the regulation of a large spectrum of both general and specialized signaling pathways. Binds to a large number of partners, usually by recognition of a phosphoserine or phosphothreonine motif. Binding generally results in the modulation of the activity of the binding partner. Positively regulates phosphorylated protein HSF1 nuclear export to the cytoplasm (PubMed:12917326).
NCBI Summary:This gene product belongs to the 14-3-3 family of proteins which mediate signal transduction by binding to phosphoserine-containing proteins. This highly conserved protein family is found in both plants and mammals, and this protein is 100% identical to the mouse ortholog. It interacts with CDC25 phosphatases, RAF1 and IRS1 proteins, suggesting its role in diverse biochemical activities related to signal transduction, such as cell division and regulation of insulin sensitivity. It has also been implicated in the pathogenesis of small cell lung cancer. Two transcript variants, one protein-coding and the other non-protein-coding, have been found for this gene. [provided by RefSeq, Aug 2008]
UniProt Code:P62258
NCBI GenInfo Identifier:51702210
NCBI Gene ID:7531
NCBI Accession:P62258.1
UniProt Secondary Accession:P62258,P29360, P42655, Q4VJB6, Q53XZ5, Q63631, Q7M4R4 B3KY71, D3DTH5,
UniProt Related Accession:P62258
Molecular Weight:26,504 Da
NCBI Full Name:14-3-3 protein epsilon
NCBI Synonym Full Names:tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein epsilon
NCBI Official Symbol:YWHAE  
NCBI Official Synonym Symbols:MDS; HEL2; MDCR; KCIP-1; 14-3-3E  
NCBI Protein Information:14-3-3 protein epsilon
UniProt Protein Name:14-3-3 protein epsilon
Protein Family:14-3-3 protein
UniProt Gene Name:YWHAE  

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