Anti-14-3-3 beta/Theta Antibody (CAB9156)

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SKU:
CAB9156
Product type:
Antibody
Antibody Type:
Monoclonal Antibody
Reactivity:
Human
Mouse
Rat
Host Species:
Rabbit
Isotype:
IgG
Synonyms:
GW128
HEL-S-1
HS1
KCIP-1
YWHAA
Frequently bought together:

Description

Product Name:14-3-3 beta/Theta Rabbit mAb
Product Code:CAB9156
Size:20uL, 50uL, 100uL
Synonyms:GW128, HEL-S-1, HS1, KCIP-1, YWHAA
Applications:WB
Reactivity:Human, Mouse, Rat
Host Species:Rabbit
Immunogen:A synthesized peptide derived from human 14-3-3 beta/Theta
Applications:WB
Recommended Dilutions:WB 1:500 - 1:2000
Reactivity:Human, Mouse, Rat
Positive Samples:HT-29, A-549, NIH/3T3, Jurkat, Mouse brain, Mouse kidney, Rat lung, Rat brain, Rat spleen
Immunogen:A synthesized peptide derived from human 14-3-3 beta/Theta
Purification Method:Affinity purification
Storage:Store at -20°C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 0.05% BSA, 50% glycerol, pH7.3.
Isotype:IgG
Sequence:Email for sequence
Gene ID:7529/7534
Uniprot:P31946/P63104
Calculated MW:28kDa
Observed MW:28KDa
UniProt Protein Function:14-3-3 beta: a protein of the 14-3-3 family of proteins which mediate signal transduction by binding to phosphoserine-containing proteins. A multifunctional regulator of the cell signaling processes.
UniProt Protein Details:

Protein type:Adaptor/scaffold

Chromosomal Location of Human Ortholog: 20q13.1

Cellular Component: focal adhesion; cytoplasmic vesicle membrane; membrane; transcriptional repressor complex; perinuclear region of cytoplasm; cytoplasm; melanosome; nucleus; cytosol

Molecular Function:protein C-terminus binding; protein domain specific binding; protein binding; enzyme binding; histone deacetylase binding; protein complex binding; phosphoprotein binding; transcription corepressor activity; phosphoserine binding

Biological Process: epidermal growth factor receptor signaling pathway; negative regulation of protein amino acid dephosphorylation; positive regulation of catalytic activity; axon guidance; fibroblast growth factor receptor signaling pathway; nerve growth factor receptor signaling pathway; activation of MAPKK activity; protein heterooligomerization; apoptosis; MAPKKK cascade; small GTPase mediated signal transduction; Ras protein signal transduction; insulin receptor signaling pathway; cytoplasmic sequestering of protein; innate immune response; gene expression; vascular endothelial growth factor receptor signaling pathway; negative regulation of transcription, DNA-dependent; protein targeting

NCBI Summary:This gene encodes a protein belonging to the 14-3-3 family of proteins, members of which mediate signal transduction by binding to phosphoserine-containing proteins. This highly conserved protein family is found in both plants and mammals. The encoded protein has been shown to interact with RAF1 and CDC25 phosphatases, suggesting that it may play a role in linking mitogenic signaling and the cell cycle machinery. Two transcript variants, which encode the same protein, have been identified for this gene. [provided by RefSeq, Jul 2008]
UniProt Code:P31946
NCBI GenInfo Identifier:1345590
NCBI Gene ID:7529
NCBI Accession:P31946.3
UniProt Secondary Accession:P31946,A8K9K2, E1P616,
UniProt Related Accession:P31946
Molecular Weight:246
NCBI Full Name:14-3-3 protein beta/alpha
NCBI Synonym Full Names:tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta
NCBI Official Symbol:YWHAB  
NCBI Official Synonym Symbols:HS1; GW128; YWHAA; KCIP-1; HEL-S-1  
NCBI Protein Information:14-3-3 protein beta/alpha; 14-3-3 alpha; protein 1054; epididymis secretory protein Li 1; brain protein 14-3-3, beta isoform; protein kinase C inhibitor protein 1; protein kinase C inhibitor protein-1; tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, beta polypeptide; tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, alpha polypeptide
UniProt Protein Name:14-3-3 protein beta/alpha
UniProt Synonym Protein Names:Protein 1054; Protein kinase C inhibitor protein 1; KCIP-1
Protein Family:14-3-3 protein
UniProt Gene Name:YWHAB  
UniProt Entry Name:1433B_HUMAN

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