ANGPTL3 Antibody (PACO23022)
- SKU:
- PACO23022
- Product type:
- Antibody
- Reactivity:
- Human
- Mouse
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Application:
- ELISA
- Application:
- WB
- Application:
- IHC
- Antibody type:
- Polyclonal
- Conjugation:
- Unconjugated
Description
Antibody Name: | ANGPTL3 Antibody (PACO23022) |
Antibody SKU: | PACO23022 |
Size: | 100ul |
Host Species: | Rabbit |
Tested Applications: | ELISA, WB, IHC |
Recommended Dilutions: | ELISA:1:2000-1:10000, WB:1:500-1:1000, IHC:1:50-1:200 |
Species Reactivity: | Human, Mouse, Rat |
Immunogen: | Fusion protein corresponding to C terminal 300 amino acids of Human Angiopoietin-related protein 3 |
Form: | Liquid |
Storage Buffer: | Supplied at 0.8mg/mL in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.3, 0.05% sodium azide and 50% glycerol. |
Purification Method: | Affinity purification |
Clonality: | Polyclonal |
Isotype: | IgG |
Conjugate: | Non-conjugated |
Gel: 10%SDS-PAGE Lysate: 30 ug Human liver cancer tissue lysate Primary antibody: 1/400 dilution Secondary antibody: Donkey anti Rabbit IgG - H&L (HRP) at 1/ 3000 dilution Exposure time: 1 minute. | |
The image on the left is immunohistochemistry of paraffin-embedded Human breast cancer tissue using 31029(ANGPTL3 Antibody) at dilution 1/8, on the right is treated with the fusion protein. |
Background: | The protein encoded by this gene is a member of the angiopoietin-like family of secreted factors. It is predominantly expressed in the liver, and has the characteristic structure of angiopoietins, consisting of a signal peptide, N-terminal coiled-coil domain and the C-terminal fibrinogen (FBN)-like domain. The FBN-like domain in angiopoietin-like 3 protein was shown to bind alpha-5/beta-3 integrins, and this binding induced endothelial cell adhesion and migration. This protein may also play a role in the regulation of angiogenesis. |
Synonyms: | Angiopoietin-related protein 3, FHBL2, ANGPT5 |
UniProt Protein Function: | ANGPTL3: Defects in ANGPTL3 are the cause of familial hypobetalipoproteinemia type 2 (FHBL2); also called combined hypobetalipoproteinemia familial. FHBL2 is a disorder of lipid metabolism characterized by less than 5th percentile age- and sex-specific levels of low density lipoproteins, and dietary fat malabsorption. Affected individuals present with combined hypolipidemia, consisting of extremely low plasma levels of LDL cholesterol, HDL cholesterol, and triglycerides. |
UniProt Protein Details: | Protein type:Secreted; Cell adhesion; Inhibitor; Motility/polarity/chemotaxis; Secreted, signal peptide Chromosomal Location of Human Ortholog: 1p31.3 Cellular Component: extracellular space; cell surface Molecular Function:integrin binding; enzyme inhibitor activity; phospholipase inhibitor activity; growth factor activity Biological Process: integrin-mediated signaling pathway; cholesterol metabolic process; phospholipid catabolic process; glycerol metabolic process; cell-matrix adhesion; lipid homeostasis; positive regulation of lipid catabolic process; fatty acid metabolic process; signal transduction; sequestering of lipid; positive regulation of angiogenesis; cholesterol homeostasis; acylglycerol homeostasis; phospholipid metabolic process; artery morphogenesis; negative regulation of lipoprotein lipase activity; positive regulation of cell migration; phospholipid homeostasis Disease: Hypobetalipoproteinemia, Familial, 2 |
NCBI Summary: | This gene encodes a member of a family of secreted proteins that function in angiogenesis. The encoded protein, which is expressed predominantly in the liver, is further processed into an N-terminal coiled-coil domain-containing chain and a C-terminal fibrinogen chain. The N-terminal chain is important for lipid metabolism, while the C-terminal chain may be involved in angiogenesis. Mutations in this gene cause familial hypobetalipoproteinemia type 2. [provided by RefSeq, Aug 2015] |
UniProt Code: | Q9Y5C1 |
NCBI GenInfo Identifier: | 25008126 |
NCBI Gene ID: | 27329 |
NCBI Accession: | Q9Y5C1.1 |
UniProt Related Accession: | Q9Y5C1 |
Molecular Weight: | ~ 54kDa |
NCBI Full Name: | Angiopoietin-related protein 3 |
NCBI Synonym Full Names: | angiopoietin like 3 |
NCBI Official Symbol: | ANGPTL3 |
NCBI Official Synonym Symbols: | ANL3; ANG-5; FHBL2; ANGPT5 |
NCBI Protein Information: | angiopoietin-related protein 3 |
UniProt Protein Name: | Angiopoietin-related protein 3 |
UniProt Synonym Protein Names: | Angiopoietin-5; ANG-5; Angiopoietin-like protein 3 |
Protein Family: | Angiopoietin-related protein |
UniProt Gene Name: | ANGPTL3 |
UniProt Entry Name: | ANGL3_HUMAN |
Secondary Antibody |
Anti-HRP Goat Anti-Rabbit IgG (H+L) Antibody (CABS014) |
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