Alpl Antibody (PACO33760)
- SKU:
- PACO33760
- Product type:
- Antibody
- Reactivity:
- Mouse
- Host Species:
- Rabbit
- Isotype:
- IgG
- Application:
- ELISA
- Antibody type:
- Polyclonal
- Conjugation:
- Unconjugated
Frequently bought together:
Description
| Antibody Name: | Alpl Antibody (PACO33760) |
| Antibody SKU: | PACO33760 |
| Size: | 50ug |
| Host Species: | Rabbit |
| Tested Applications: | ELISA |
| Recommended Dilutions: | |
| Species Reactivity: | Mouse |
| Immunogen: | Recombinant Mouse Alkaline phosphatase, tissue-nonspecific isozyme protein (20-503AA) |
| Form: | Liquid |
| Storage Buffer: | Preservative: 0.03% Proclin 300 Constituents: 50% Glycerol, 0.01M PBS, PH 7.4 |
| Purification Method: | >95%, Protein G purified |
| Clonality: | Polyclonal |
| Isotype: | IgG |
| Conjugate: | Non-conjugated |
| Background: | This isozyme may play a role in skeletal mineralization. |
| Synonyms: | Alkaline phosphatase, tissue-nonspecific isozyme (AP-TNAP) (TNSALP) (EC 3.1.3.1) (Alkaline phosphatase 2) (Alkaline phosphatase liver/bone/kidney isozyme), Alpl, Akp-2 Akp2 |
| UniProt Protein Function: | This isozyme may play a role in skeletal mineralization. |
| UniProt Protein Details: | |
| NCBI Summary: | This gene encodes a preproprotein that is proteolytically cleaved to yield a signal peptide and a proproptein that is subsequently processed to generate the active mature peptide. The encoded protein is a membrane-bound glycosylated enzyme that catalyzes the hydrolysis of phosphate esters at alkaline pH. The mature peptide maintains the ratio of inorganic phosphate to inorganic pyrophosphate required for bone mineralization. Mice that lack this enzyme show symptoms of osteomalacia, softening of the bones. In humans, mutations in this gene are associated with hypophosphatasia, an inherited metabolic bone disease in which deficiency of this enzyme inhibits bone mineralization leading to skeletal defects. Mutations in the mouse gene mirror the symptoms of human hypophosphatasia. A pseudogene of this gene is present on chromosome X. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2015] |
| UniProt Code: | P09242 |
| NCBI GenInfo Identifier: | 563317855 |
| NCBI Gene ID: | 11647 |
| NCBI Accession: | NP_001274101.1 |
| UniProt Secondary Accession: | P09242,Q6P1B0 |
| UniProt Related Accession: | P09242 |
| Molecular Weight: | 57,514 Da |
| NCBI Full Name: | alkaline phosphatase, tissue-nonspecific isozyme preproprotein |
| NCBI Synonym Full Names: | alkaline phosphatase, liver/bone/kidney |
| NCBI Official Symbol: | Alpl |
| NCBI Official Synonym Symbols: | ALP; Akp2; TNAP; Akp-2; APTNAP; TNSALP |
| NCBI Protein Information: | alkaline phosphatase, tissue-nonspecific isozyme |
| UniProt Protein Name: | Alkaline phosphatase, tissue-nonspecific isozyme |
| UniProt Synonym Protein Names: | Alkaline phosphatase 2; Alkaline phosphatase liver/bone/kidney isozyme |
| Protein Family: | Alkaline proteinase |
| UniProt Gene Name: | Alpl |
| UniProt Entry Name: |
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