Alpha-amanitin proprotein Antibody (PACO34040)
- SKU:
- PACO34040
- Product type:
- Antibody
- Reactivity:
- Amanita phalloides
- Host Species:
- Rabbit
- Isotype:
- IgG
- Application:
- ELISA
- Antibody type:
- Polyclonal
- Conjugation:
- Unconjugated
Frequently bought together:
Description
| Antibody Name: | Alpha-amanitin proprotein Antibody (PACO34040) |
| Antibody SKU: | PACO34040 |
| Size: | 50ug |
| Host Species: | Rabbit |
| Tested Applications: | ELISA |
| Recommended Dilutions: | |
| Species Reactivity: | Amanita phalloides |
| Immunogen: | Peptide sequence from Amanita phalloides Alpha-amanitin proprotein protein |
| Form: | Liquid |
| Storage Buffer: | Preservative: 0.03% Proclin 300 Constituents: 50% Glycerol, 0.01M PBS, PH 7.4 |
| Purification Method: | >95%, Protein G purified |
| Clonality: | Polyclonal |
| Isotype: | IgG |
| Conjugate: | Non-conjugated |
| Background: | Major toxin from Amanita phalloideae. Acts by binding non-competitively to RNA polymerase II and greatly slowing the elongation of transcripts from target promoters. |
| Synonyms: | Alpha-amanitin proprotein (Alpha-amanitin) (Amatoxin) (Gamma-amanitin) |
| UniProt Protein Function: | Function: Major toxin from Amanita phalloideae. Acts by binding non-competitively to RNA polymerase II and greatly slowing the elongation of transcripts from target promoters. Ref.1 Ref.2 Ref.3 Ref.4Toxic dose: LD50 is 0.35 mg/kg by intraperitoneal injection into mice. LD50 is 4 mg/kg by intravenous injection into rats, and 0.1 mg/kg by intravenous injection into dogs. LD50 is 2 µg/kg by intracerebroventricular injection into mice, and 10 µg/kg by intracerebroventricular injection into rats. Ref.3Caution: This peptide is cyclic. The peptide order is assigned by homology with the gene sequence for alpha-amanitin from Amanita bisporigera. Ref.4In peptide sequencing work prior to 1968, the residue shown in the first position was reported as a beta-methylleucine derivative that could arise by either beta-methylation of leucine or gamma-methylation of isoleucine. The correct structure has been determined to be derived from isoleucine without methylation. Ref.4 |
| UniProt Protein Details: | |
| NCBI Summary: | |
| UniProt Code: | P85421 |
| NCBI GenInfo Identifier: | 205686182 |
| NCBI Gene ID: | |
| NCBI Accession: | P85421.1 |
| UniProt Secondary Accession: | P85421 |
| UniProt Related Accession: | P85421 |
| Molecular Weight: | 859 Da |
| NCBI Full Name: | Amatoxin |
| NCBI Synonym Full Names: | |
| NCBI Official Symbol: | |
| NCBI Official Synonym Symbols: | |
| NCBI Protein Information: | |
| UniProt Protein Name: | Amatoxin |
| UniProt Synonym Protein Names: | Alpha-amanitin; Gamma-amanitin |
| Protein Family: | Amatoxin |
| UniProt Gene Name: | |
| UniProt Entry Name: | AMATX_AMAPH |
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