AKR1A1 Antibody (PACO22130)
- SKU:
- PACO22130
- Product type:
- Antibody
- Reactivity:
- Human
- Mouse
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Application:
- ELISA
- Application:
- WB
- Antibody type:
- Polyclonal
- Conjugation:
- Unconjugated
Frequently bought together:
Description
| Antibody Name: | AKR1A1 Antibody (PACO22130) |
| Antibody SKU: | PACO22130 |
| Size: | 100ul |
| Host Species: | Rabbit |
| Tested Applications: | ELISA, WB |
| Recommended Dilutions: | ELISA:1:2000-1:10000, WB:1:500-1:3000 |
| Species Reactivity: | Human, Mouse, Rat |
| Immunogen: | Synthesized peptide derived from C-terminal of human AKR1A1. |
| Form: | Liquid |
| Storage Buffer: | Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. |
| Purification Method: | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Clonality: | Polyclonal |
| Isotype: | IgG |
| Conjugate: | Non-conjugated |
 | Western blot analysis of extracts from COLO205 cells and NIH-3T3 cells, using AKR1A1 antibody. |
| Background: | Catalyzes the NADPH-dependent reduction of a variety of aromatic and aliphatic aldehydes to their corresponding alcohols. Catalyzes the reduction of mevaldate to mevalonic acid and of glyceraldehyde to glycerol. Has broad substrate specificity. In vitro substrates include succinic semialdehyde, 4-nitrobenzaldehyde, 1,2-naphthoquinone, methylglyoxal, and D-glucuronic acid. Plays a role in the activation of procarcinogens, such as polycyclic aromatic hydrocarbon trans-dihydrodiols, and in the metabolism of various xenobiotics and drugs, including the anthracyclines doxorubicin (DOX) and daunorubicin (DAUN). |
| Synonyms: | AK1A1; AKR1A1; alcohol dehydrogenase; Alcohol dehydrogenase [NADP+]; Aldehyde reductase |
| UniProt Protein Function: | AKR1A1: Catalyzes the NADPH-dependent reduction of a variety of aromatic and aliphatic aldehydes to their corresponding alcohols. Catalyzes the reduction of mevaldate to mevalonic acid and of glyceraldehyde to glycerol. Has broad substrate specificity. In vitro substrates include succinic semialdehyde, 4- nitrobenzaldehyde, 1,2-naphthoquinone, methylglyoxal, and D- glucuronic acid. Plays a role in the activation of procarcinogens, such as polycyclic aromatic hydrocarbon trans-dihydrodiols, and in the metabolism of various xenobiotics and drugs, including the anthracyclines doxorubicin (DOX) and daunorubicin (DAUN). Belongs to the aldo/keto reductase family. |
| UniProt Protein Details: | Protein type:EC 1.1.1.2; Oxidoreductase; Carbohydrate Metabolism - glycolysis and gluconeogenesis; Lipid Metabolism - glycerolipid Chromosomal Location of Human Ortholog: 1p33-p32 Cellular Component: cytosol; extracellular space Molecular Function:aldo-keto reductase activity; electron carrier activity; L-glucuronate reductase activity; protein binding Biological Process: aldehyde metabolic process; glucose metabolic process; glucuronate catabolic process to xylulose 5-phosphate |
| NCBI Summary: | This gene encodes a member of the aldo/keto reductase superfamily, which consists of more than 40 known enzymes and proteins. This member, also known as aldehyde reductase, is involved in the reduction of biogenic and xenobiotic aldehydes and is present in virtually every tissue. Multiple alternatively spliced transcript variants of this gene exist, all encoding the same protein. [provided by RefSeq, Jan 2011] |
| UniProt Code: | P14550 |
| NCBI GenInfo Identifier: | 113600 |
| NCBI Gene ID: | 10327 |
| NCBI Accession: | P14550.3 |
| UniProt Secondary Accession: | P14550,Q6IAZ4, A8KAL8, D3DQ04, |
| UniProt Related Accession: | P14550 |
| Molecular Weight: | 36,573 Da |
| NCBI Full Name: | Alcohol dehydrogenase |
| NCBI Synonym Full Names: | aldo-keto reductase family 1 member A1 |
| NCBI Official Symbol: | AKR1A1 |
| NCBI Official Synonym Symbols: | ALR; ARM; DD3; ALDR1; HEL-S-6 |
| NCBI Protein Information: | alcohol dehydrogenase [NADP(+)] |
| UniProt Protein Name: | Alcohol dehydrogenase [NADP(+)] |
| UniProt Synonym Protein Names: | Aldehyde reductase; Aldo-keto reductase family 1 member A1 |
| Protein Family: | Alcohol dehydrogenase |
| UniProt Gene Name: | AKR1A1 |
| UniProt Entry Name: | AK1A1_HUMAN |
| Antibodies |
| Anti-AKR1A1 Antibody (CAB1068) |
| Anti-AKR1A1 Antibody (CAB13577) |
| Anti-AKR1A1 Antibody (CAB18014)[KO Validated] |
| AKR1A1 Antibody (PACO06242) |
| AKR1A1 Antibody (PACO07670) |
| Secondary Antibody |
| Anti-HRP Goat Anti-Rabbit IgG (H+L) Antibody (CABS014) |
| Recommended Products |
| Anti-FITC Goat Anti-Rabbit IgG (H+L) Antibody (CABS011) |
| Anti-HRP-conjugated Beta Actin Antibody (CABC028) |
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Anti-AKR1A1 Antibody (CAB13577)
Anti-AKR1A1 Antibody (CAB1068)
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