AKR1A1 Antibody (PACO18541)
- SKU:
- PACO18541
- Product type:
- Antibody
- Reactivity:
- Human
- Mouse
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Application:
- ELISA
- Application:
- WB
- Application:
- IHC
- Antibody type:
- Polyclonal
- Conjugation:
- Unconjugated
Frequently bought together:
Description
| Antibody Name: | AKR1A1 Antibody (PACO18541) |
| Antibody SKU: | PACO18541 |
| Size: | 50ul |
| Host Species: | Rabbit |
| Tested Applications: | ELISA, WB, IHC |
| Recommended Dilutions: | ELISA:1:2000-1:5000, WB:1:500-1:2000, IHC:1:50-1:200 |
| Species Reactivity: | Human, Mouse, Rat |
| Immunogen: | Synthetic peptide of human AKR1A1 |
| Form: | Liquid |
| Storage Buffer: | -20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol |
| Purification Method: | Antigen affinity purification |
| Clonality: | Polyclonal |
| Isotype: | IgG |
| Conjugate: | Non-conjugated |
 | The image on the left is immunohistochemistry of paraffin-embedded Human ovarian cancer tissue using PACO18541(AKR1A1 Antibody) at dilution 1/30, on the right is treated with synthetic peptide. (Original magnification: x200). |
 | Gel: 10%SDS-PAGE, Lysate: 27 μg, Lane 1-3: Human liver cancer tissue, hela cells, 293T cells, Primary antibody: PACO18541(AKR1A1 Antibody) at dilution 1/500, Secondary antibody: Goat anti rabbit IgG at 1/8000 dilution, Exposure time: 10 seconds. |
 | The image on the left is immunohistochemistry of paraffin-embedded Human thyroid cancer tissue using PACO18541(AKR1A1 Antibody) at dilution 1/30, on the right is treated with synthetic peptide. (Original magnification: x200). |
| Background: | This gene encodes a member of the aldo/keto reductase superfamily, which consists of more than 40 known enzymes and proteins. This member, also known as aldehyde reductase, is involved in the reduction of biogenic and xenobiotic aldehydes and is present in virtually every tissue. Multiple alternatively spliced transcript variants of this gene exist, all encoding the same protein. |
| Synonyms: | Aldo-keto reductase family 1, member A1 (aldehyde reductase) |
| UniProt Protein Function: | AKR1A1: Catalyzes the NADPH-dependent reduction of a variety of aromatic and aliphatic aldehydes to their corresponding alcohols. Catalyzes the reduction of mevaldate to mevalonic acid and of glyceraldehyde to glycerol. Has broad substrate specificity. In vitro substrates include succinic semialdehyde, 4- nitrobenzaldehyde, 1,2-naphthoquinone, methylglyoxal, and D- glucuronic acid. Plays a role in the activation of procarcinogens, such as polycyclic aromatic hydrocarbon trans-dihydrodiols, and in the metabolism of various xenobiotics and drugs, including the anthracyclines doxorubicin (DOX) and daunorubicin (DAUN). Belongs to the aldo/keto reductase family. |
| UniProt Protein Details: | Protein type:EC 1.1.1.2; Oxidoreductase; Carbohydrate Metabolism - glycolysis and gluconeogenesis; Lipid Metabolism - glycerolipid Chromosomal Location of Human Ortholog: 1p33-p32 Cellular Component: cytosol; extracellular space Molecular Function:aldo-keto reductase activity; electron carrier activity; L-glucuronate reductase activity; protein binding Biological Process: aldehyde metabolic process; glucose metabolic process; glucuronate catabolic process to xylulose 5-phosphate |
| NCBI Summary: | This gene encodes a member of the aldo/keto reductase superfamily, which consists of more than 40 known enzymes and proteins. This member, also known as aldehyde reductase, is involved in the reduction of biogenic and xenobiotic aldehydes and is present in virtually every tissue. Multiple alternatively spliced transcript variants of this gene exist, all encoding the same protein. [provided by RefSeq, Jan 2011] |
| UniProt Code: | P14550 |
| NCBI GenInfo Identifier: | 113600 |
| NCBI Gene ID: | 10327 |
| NCBI Accession: | P14550.3 |
| UniProt Secondary Accession: | P14550,Q6IAZ4, A8KAL8, D3DQ04, |
| UniProt Related Accession: | P14550 |
| Molecular Weight: | 36,573 Da |
| NCBI Full Name: | Alcohol dehydrogenase |
| NCBI Synonym Full Names: | aldo-keto reductase family 1 member A1 |
| NCBI Official Symbol: | AKR1A1 |
| NCBI Official Synonym Symbols: | ALR; ARM; DD3; ALDR1; HEL-S-6 |
| NCBI Protein Information: | alcohol dehydrogenase [NADP(+)] |
| UniProt Protein Name: | Alcohol dehydrogenase [NADP(+)] |
| UniProt Synonym Protein Names: | Aldehyde reductase; Aldo-keto reductase family 1 member A1 |
| Protein Family: | Alcohol dehydrogenase |
| UniProt Gene Name: | AKR1A1 |
| UniProt Entry Name: | AK1A1_HUMAN |
| Antibodies |
| Anti-AKR1A1 Antibody (CAB1068) |
| Anti-AKR1A1 Antibody (CAB13577) |
| Anti-AKR1A1 Antibody (CAB18014)[KO Validated] |
| AKR1A1 Antibody (PACO06242) |
| AKR1A1 Antibody (PACO07670) |
| Secondary Antibody |
| Anti-HRP Goat Anti-Rabbit IgG (H+L) Antibody (CABS014) |
| Recommended Products |
| Anti-FITC Goat Anti-Rabbit IgG (H+L) Antibody (CABS011) |
| Anti-HRP-conjugated Beta Actin Antibody (CABC028) |
Related Products
Anti-AKR1A1 Antibody (CAB13577)
Anti-AKR1A1 Antibody (CAB1068)
![Anti-AKR1A1 Antibody (CAB18014)[KO Validated]](https://cdn11.bigcommerce.com/s-39x6lpnvxv/images/stencil/590x590/products/30264/28453/anti-akr1a1-antibody-cab18014ko-validated__88377__84432.1644317035.jpg?c=1 "Anti-AKR1A1 Antibody (CAB18014)[KO Validated]")
