AICDA Antibody (PACO20932)
- SKU:
- PACO20932
- Product type:
- Antibody
- Reactivity:
- Human
- Mouse
- Host Species:
- Rabbit
- Isotype:
- IgG
- Application:
- ELISA
- Application:
- IHC
- Antibody type:
- Polyclonal
- Conjugation:
- Unconjugated
Frequently bought together:
Description
| Antibody Name: | AICDA Antibody (PACO20932) |
| Antibody SKU: | PACO20932 |
| Size: | 50ul |
| Host Species: | Rabbit |
| Tested Applications: | ELISA, IHC |
| Recommended Dilutions: | ELISA:1:2000-1:5000, IHC:1:25-1:100 |
| Species Reactivity: | Human, Mouse |
| Immunogen: | Synthetic peptide of human AICDA |
| Form: | Liquid |
| Storage Buffer: | -20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol |
| Purification Method: | Antigen affinity purification |
| Clonality: | Polyclonal |
| Isotype: | IgG |
| Conjugate: | Non-conjugated |
 | The image on the left is immunohistochemistry of paraffin-embedded Human liver cancer tissue using PACO20932(AICDA Antibody) at dilution 1/35, on the right is treated with synthetic peptide. (Original magnification: x200). |
| Background: | This gene encodes a RNA-editing deaminase that is a member of the cytidine deaminase family. The protein is involved in somatic hypermutation, gene conversion, and class-switch recombination of immunoglobulin genes. Defects in this gene are the cause of autosomal recessive hyper-IgM immunodeficiency syndrome type 2 (HIGM2). |
| Synonyms: | activation-induced cytidine deaminase |
| UniProt Protein Function: | AID: Single-stranded DNA-specific cytidine deaminase. Involved in somatic hypermutation, gene conversion, and class- switch recombination in B-lymphocytes. Required for several crucial steps of B-cell terminal differentiation necessary for efficient antibody responses. May also play a role in the epigenetic regulation of gene expression by participating in DNA demethylation. Strongly expressed in lymph nodes and tonsils. Belongs to the cytidine and deoxycytidylate deaminase family. |
| UniProt Protein Details: | Protein type:EC 3.5.4.38; Hydrolase Chromosomal Location of Human Ortholog: 12p13 Cellular Component: cytoplasm; exosome (RNase complex); nucleus Molecular Function:protein binding; zinc ion binding; ubiquitin protein ligase binding; cytidine deaminase activity Biological Process: somatic diversification of immunoglobulins; B cell differentiation; somatic hypermutation of immunoglobulin genes; isotype switching; cytidine deamination; mRNA processing Disease: Immunodeficiency With Hyper-igm, Type 2 |
| NCBI Summary: | This gene encodes a RNA-editing deaminase that is a member of the cytidine deaminase family. The protein is involved in somatic hypermutation, gene conversion, and class-switch recombination of immunoglobulin genes. Defects in this gene are the cause of autosomal recessive hyper-IgM immunodeficiency syndrome type 2 (HIGM2). [provided by RefSeq, Feb 2009] |
| UniProt Code: | Q9GZX7 |
| NCBI GenInfo Identifier: | 23813666 |
| NCBI Gene ID: | 57379 |
| NCBI Accession: | Q9GZX7.1 |
| UniProt Related Accession: | Q9GZX7 |
| Molecular Weight: | |
| NCBI Full Name: | Single-stranded DNA cytosine deaminase |
| NCBI Synonym Full Names: | activation induced cytidine deaminase |
| NCBI Official Symbol: | AICDA |
| NCBI Official Synonym Symbols: | AID; ARP2; CDA2; HIGM2; HEL-S-284 |
| NCBI Protein Information: | single-stranded DNA cytosine deaminase |
| UniProt Protein Name: | Single-stranded DNA cytosine deaminase |
| UniProt Synonym Protein Names: | Activation-induced cytidine deaminase; Cytidine aminohydrolase |
| Protein Family: | AIDA-I autotransporter |
| UniProt Gene Name: | AICDA |
| UniProt Entry Name: | AICDA_HUMAN |
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