Low Endotoxin Purified Anti-Human/Mouse CD44 Antibody [IM7] (AGEL1274)

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SKU:
AGEL1274
Product Type:
Antibody
Antibody Type:
Monoclonal Antibody
Reactivity:
Human
Mouse
Applications:
FC
Frequently bought together:

Description

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Low Endotoxin Purified Anti-Human/Mouse CD44 Antibody [IM7]

The Mouse/Human CD44 Monoclonal Antibody (IM7) is a versatile tool for researchers studying CD44, a cell surface glycoprotein involved in cell adhesion, migration, and signaling. This highly pure antibody, produced from hybridoma cells, exhibits strong reactivity with both mouse and human CD44 proteins. Validated for multiple applications including flow cytometry, immunofluorescence, and immunohistochemistry, it enables precise detection and characterization of CD44 expression in various cell types and tissues.CD44 plays a crucial role in processes such as lymphocyte homing, wound healing, and cancer metastasis, making it a key target of interest in diverse fields of research, from immunology to oncology.

By specifically binding to CD44, the IM7 antibody facilitates detailed analysis of this molecule's functions, aiding in the investigation of cell behavior, disease mechanisms, and therapeutic interventions. Researchers can leverage the IM7 antibody to deepen their understanding of CD44 biology and its implications in health and disease.

Product Title:Low Endotoxin Purified Anti-Human/Mouse CD44 Antibody [IM7]
SKU:AGEL1274
Size:50µg, 500µg, 1mg
Clone No:IM7
Synonyms:CD44 antigen;CD44;CDw44;Epican;Phagocytic glycoprotein 1;PGP-1;Phagocytic glycoprotein I;PGP-I;CD44;LHR; MDU2; MDU3; MIC4;
Host Species:Rat
Reactivity:Human;Mouse
Application:FCM;Neut
Isotype:Rat IgG2b, κ
Isotype Control:AF/LE Purified Rat IgG2b, κ Isotype Control[LTF-2]
Form:Liquid
Conjugation:None (AF/LE)
Recommended Use:Each lot of this antibody is quality control tested by flow cytometric analysis. For flow cytometric staining, the suggested use of this reagent is ≤ 2.0 µg per 106 cells in 100 µL volume or 100 µL of whole blood. It is recommended that the reagent be titrated for optimal performance for each application.
Swissprot:P15379 P16070
Gene ID:12505,960
Storage Buffer:0.2 μm filtered in PBS, pH 7.2. Azide Free (AF)/Low Endotoxin (LE): Contains no stabilizers or stabilizers. Endotoxin level is < 2 EU/mg as Determined by LAL gel clotting assay.
Stability & Storage:Keep as concentrated solution. Store at 2~8°C and protected from prolonged exposure to light. Do not freeze. Centrifuge before opening to ensure complete recovery of vial contents. This product is guaranteed up to one year from purchase.
Background:CD44 is a 80-95 kD glycoprotein also known as Hermes, Pgp1, H-CAM, or HUTCH. It is expressed on all leukocytes, endothelial cells, hepatocytes, and mesenchymal cells. As B and T cells become activated or progress to the memory stage, CD44 expression increases from low or mid levels to high levels. Thus, CD44 has been reported to be a valuable marker for memory cell subsets. High CD44 expression on Treg cells has been associated with potent suppressive function via high production of IL-10. CD44 is an adhesion molecule involved in leukocyte attachment to and rolling on endothelial cells, homing to peripheral lymphoid organs and to the sites of inflammation, and leukocyte aggregation.

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