Low Endotoxin Purified Anti-Mouse CD62L Antibody [Mel14] (AGEL0626)

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SKU:
AGEL0626
Product Type:
Antibody
Antibody Type:
Monoclonal Antibody
Reactivity:
Mouse
Applications:
FC
Frequently bought together:

Description

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Low Endotoxin Purified Anti-Mouse CD62L Antibody [Mel14]

The AFLE Purified Mouse CD62L Monoclonal Antibody (MEL-14) is a high-quality research tool designed for investigating CD62L, a protein crucial for immune cell trafficking and homing to lymphoid tissues. This monoclonal antibody, derived from mouse hybridoma cells, exhibits strong reactivity with CD62L in mouse samples and is validated for use in flow cytometry and immunohistochemistry applications.CD62L, also known as L-selectin, plays a key role in the adhesion and migration of immune cells, particularly lymphocytes. Its involvement in immune cell interactions with endothelial cells and lymphoid tissues underscores its importance in immune surveillance and responses.

Research on CD62L is instrumental in understanding immune cell dynamics, especially in the context of inflammation, infection, and immune system disorders.By utilizing the AFLE Purified Mouse CD62L Monoclonal Antibody (MEL-14), researchers can effectively detect and analyze CD62L expression in different cell populations, shedding light on its functional role in immune processes. This antibody is a valuable tool for immunologists, cell biologists, and researchers studying immune cell trafficking, inflammation, and immune responses in various disease models.

Product Title:Low Endotoxin Purified Anti-Mouse CD62L Antibody [Mel14]
SKU:AGEL0626
Size:50µg, 500µg, 1mg
Clone No:Mel14
Synonyms:L-selectin;Sell;CD62 antigen-like family member L;LAM-1;LECAM1;Lymph node homing receptor;Ly-22; CD62L;Lnhr;Ly22;
Host Species:Rat
Reactivity:Mouse
Application:FCM;Neut
Isotype:Rat IgG2a, κ
Isotype Control:AF/LE Purified Rat IgG2a, κ Isotype Control[2A3]
Form:Liquid
Conjugation:None (AF/LE)
Recommended Use:Each lot of this antibody is quality control tested by flow cytometric analysis. For flow cytometric staining, the suggested use of this reagent is ≤ 0.25 µg per 106 cells in 100 µL volume or 100 µL of whole blood. It is recommended that the reagent be titrated for optimal performance for each application.
Swissprot:P18337
Gene ID:20343
Storage Buffer:0.2 μm filtered in PBS, pH 7.2. Azide Free (AF)/Low Endotoxin (LE): Contains no stabilizers or stabilizers. Endotoxin level is < 2 EU/mg as Determined by LAL gel clotting assay.
Stability & Storage:Keep as concentrated solution. Store at 2~8°C and protected from prolonged exposure to light. Do not freeze. Centrifuge before opening to ensure complete recovery of vial contents. This product is guaranteed up to one year from purchase.
Background:CD62L is a 74-95 kD glycoprotein also known as L-selectin, LECAM-1, Ly-22, LAM-1, and MEL-14. It is a member of the selectin family and is expressed on the majority of B and naïve T cells, a subset of memory T cells, monocytes, granulocytes, most thymocytes, and a subset of NK cells. CD62L is important in lymphocyte homing to high endothelial venules (HEV) in peripheral lymph nodes and leukocyte 'rolling' on activated endothelium. CD62L also contributes to neutrophil emigration at inflammatory sites. CD62L is rapidly shed from lymphocytes and neutrophils upon cellular activation and the expression levels of CD62L (in conjunction with other markers) have been used to distinguish naïve, effector, and memory T cells. CD62L has been reported to interact with CD34, GlyCAM-1, and MAdCAM-1.

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