Low Endotoxin Purified Anti-Mouse CD117 Antibody [2B8] (AGEL1181)

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SKU:
AGEL1181
Product Type:
Antibody
Antibody Type:
Monoclonal Antibody
Reactivity:
Mouse
Applications:
FC
Frequently bought together:

Description

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Low Endotoxin Purified Anti-Mouse CD117 Antibody [2B8]

The Mouse CD117 Monoclonal Antibody (2B8) from AssayGenie (AGEL1181) is a specialized tool for researchers investigating CD117, a cell surface receptor protein commonly known as c-Kit. This monoclonal antibody, produced using hybridoma technology, exhibits a high degree of specificity and sensitivity towards mouse samples, making it an excellent choice for immunohistochemistry, flow cytometry, and other experimental techniques.CD117, a receptor for stem cell factor (SCF), plays fundamental roles in various biological processes, including hematopoiesis, gametogenesis, and melanogenesis. Its dysregulation is associated with conditions like cancer, leukemia, and mastocytosis, highlighting the importance of studying its expression patterns and signaling pathways.

The Mouse CD117 Monoclonal Antibody (2B8) facilitates the detection and analysis of CD117 in diverse cell types, enabling detailed investigations into its function in developmental biology, oncology, and regenerative medicine.By using this antibody, researchers can gain valuable insights into the molecular mechanisms controlled by CD117, paving the way for novel therapeutic approaches and potential diagnostic markers in diseases where CD117 is implicated. With its reliability and versatility, the Mouse CD117 Monoclonal Antibody (2B8) is a valuable asset for advancing the understanding of CD117 biology and its implications in health and disease.

Product Title:Low Endotoxin Purified Anti-Mouse CD117 Antibody [2B8]
SKU:AGEL1181
Size:50µg, 500µg, 1mg
Clone No:2B8
Synonyms:Mast/stem cell growth factor receptor Kit;Kit;SCFR;Proto-oncogene c-Kit;Tyrosine-protein kinase Kit;CD117;
Host Species:Rat
Reactivity:Mouse
Application:FCM
Isotype:Rat IgG2b, κ
Isotype Control:AF/LE Purified Rat IgG2b, κ Isotype Control[LTF-2]
Form:Liquid
Conjugation:None (AF/LE)
Recommended Use:Each lot of this antibody is quality control tested by flow cytometric analysis. For flow cytometric staining, the suggested use of this reagent is ≤ 2.0 µg per 106 cells in 100 µL volume or 100 µL of whole blood. It is recommended that the reagent be titrated for optimal performance for each application.
Swissprot:P05532
Gene ID:16590
Storage Buffer:0.2 μm filtered in PBS, pH 7.2. Azide Free (AF)/Low Endotoxin (LE): Contains no stabilizers or stabilizers. Endotoxin level is < 2 EU/mg as Determined by LAL gel clotting assay.
Stability & Storage:Keep as concentrated solution. Store at 2~8°C and protected from prolonged exposure to light. Do not freeze. Centrifuge before opening to ensure complete recovery of vial contents. This product is guaranteed up to one year from purchase.
Background:CD117 is a 145 kD immunoglobulin superfamily member also known as c-Kit and stem cell factor receptor (SCFR). It is a transmembrane tyrosine-kinase receptor that binds the c-Kit ligand (also known as steel factor, stem cell factor, and mast cell growth factor). CD117 is expressed on hematopoietic stem cells (including multipotent hematopoietic stem cells, progenitors committed to myeloid and/or erythroid lineages, and T and B cell precursors), mast cells, and acute myeloid leukemia (AML) cells. CD117 interaction with its ligand is critical for the development of hematopoietic stem cells.

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