Low Endotoxin Purified Anti-Mouse CD115 Antibody [AFS98] (AGEL1365)

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SKU:
AGEL1365
Product Type:
Antibody
Antibody Type:
Monoclonal Antibody
Reactivity:
Mouse
Applications:
FC
Frequently bought together:

Description

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Low Endotoxin Purified Anti-Mouse CD115 Antibody [AFS98]

The Mouse CD115 Monoclonal Antibody (AFS98) is a highly specific antibody designed for research applications involving CD115, a key cell surface receptor in the development and functioning of monocytes and macrophages. This antibody, purified from mouse cells, exhibits exceptional reactivity with mouse samples and has been validated for use in various experimental techniques, including flow cytometry and immunohistochemistry.CD115, also known as colony-stimulating factor 1 receptor (CSF1R), plays a vital role in regulating the differentiation, survival, and function of mononuclear phagocytic cells.

Its involvement in immune responses, inflammation, and tissue homeostasis positions it as a critical target for investigations in immunology, oncology, and inflammatory diseases. By targeting CD115, researchers can gain insights into the roles of monocytes and macrophages in health and disease, paving the way for the development of novel therapeutic strategies targeting these cell populations.

Product Title:Low Endotoxin Purified Anti-Mouse CD115 Antibody [AFS98]
SKU:AGEL1365
Size:50µg, 500µg, 1mg
Clone No:AFS98
Synonyms:Macrophage colony-stimulating factor 1 receptor;CSF-1 receptor (EC:2.7.10.1);CSF-1-R;CSF-1R;M-CSF-R;Proto-oncogene c-Fms;CD115;Csf1r;Csfmr;Fms;
Host Species:Rat
Reactivity:Mouse
Application:FCM;Block;Depletion;Neut
Isotype:Rat IgG2a, κ
Isotype Control:AF/LE Purified Rat IgG2a, κ Isotype Control[2A3]
Form:Liquid
Conjugation:None (AF/LE)
Recommended Use:Each lot of this antibody is quality control tested by flow cytometric analysis. For flow cytometric staining, the suggested use of this reagent is ≤ 2.0 µg per 106 cells in 100 µL volume or 100 µL of whole blood. It is recommended that the reagent be titrated for optimal performance for each application.
Swissprot:P09581
Gene ID:12978
Storage Buffer:0.2 μm filtered in PBS, pH 7.2. Azide Free (AF)/Low Endotoxin (LE): Contains no stabilizers or stabilizers. Endotoxin level is < 2 EU/mg as Determined by LAL gel clotting assay.
Stability & Storage:Keep as concentrated solution. Store at 2~8°C and protected from prolonged exposure to light. Do not freeze. Centrifuge before opening to ensure complete recovery of vial contents. This product is guaranteed up to one year from purchase.
Background:CSF-1R, also known as CD115 and M-CSFR, is a single-pass type I membrane protein and member of the platelet-derived growth factor receptor family. This c-fms (Fms proto-oncogene) gene product's natural ligands include M-CSF and IL-34. Structural studies of CD115 have described an Ig-like extracellular domain, a transmembrane domain, an intracellular juxtamembrane domain, a split tyrosine kinase domain, and a C-terminal tail receptor. Receptor activation induces homodimerization in addition to phosphorylation and ubiquitination of intracellular residues. CD115 directly influences tissue macrophage and osteoclast differentiation and proliferation. It is expressed on monocytes/macrophages, peritoneal exudate cells, plasmacytoid and conventional dendritic cells, and osteoclasts.

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