The CD44 Monoclonal Antibody (AGEL2101) offered by Assay Genie is a high-quality purified antibody designed for research applications involving the CD44 protein, a cell surface glycoprotein that plays a crucial role in cell adhesion, migration, and signaling. This monoclonal antibody, generated against human CD44, is validated for use in various experimental techniques, including Western blotting, immunoprecipitation, and flow cytometry.CD44 is a multifunctional molecule involved in processes such as cell-cell interactions, lymphocyte activation, and tumor metastasis. Its diverse functions make it a promising target for studies in immunology, oncology, and stem cell research.
The specificity and reliability of the AGEL2101 antibody enable precise detection and analysis of CD44 expression in different biological samples, facilitating in-depth investigations into the roles of CD44 in various physiological and pathological conditions.Researchers working on understanding the mechanisms of cell adhesion, migration, and cancer progression will find the CD44 Monoclonal Antibody (AGEL2101) to be an invaluable tool in their experimental endeavors. Its superior performance and accuracy make it a trusted reagent for elucidating the complex functions of CD44 and its implications in health and disease.
Each lot of this antibody is quality control tested by flow cytometric analysis. For flow cytometric staining, the suggested use of this reagent is ≤ 2.0 µg per 106 cells in 100 µL volume or 100 µL of whole blood. It is recommended that the reagent be titrated for optimal performance for each application.
Swissprot:
P16070
Gene ID:
960
Storage Buffer:
0.2 μm filtered in PBS, pH 7.2. Azide Free (AF)/Low Endotoxin (LE): Contains no stabilizers or stabilizers. Endotoxin level is < 2 EU/mg as Determined by LAL gel clotting assay.
Stability & Storage:
Keep as concentrated solution. Store at 2~8°C and protected from prolonged exposure to light. Do not freeze. Centrifuge before opening to ensure complete recovery of vial contents. This product is guaranteed up to one year from purchase.
Background:
CD44 is a 80-95 kD glycoprotein also known as Hermes, Pgp1, H-CAM, or HUTCH. It is expressed on all leukocytes, endothelial cells, hepatocytes, and mesenchymal cells. As B and T cells become activated or progress to the memory stage, CD44 expression increases from a low or mid level of intensity to high expression levels. Thus, CD44 has been reported to be a valuable marker for memory cell subsets. CD44 is an adhesion molecule involved in leukocyte attachment to and rolling on endothelial cells, homing to peripheral lymphoid organs and to the sites of inflammation, and leukocyte aggregation.