Low Endotoxin Purified Anti-Human CD279/PD-1 Antibody [J116] (AGEL1606)

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SKU:
AGEL1606
Product Type:
Antibody
Antibody Type:
Monoclonal Antibody
Reactivity:
Human
Applications:
FC
Frequently bought together:

Description

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Low Endotoxin Purified Anti-Human CD279/PD-1 Antibody [J116]

The Purified Human CD279 (PD-1) Monoclonal Antibody (J116) is a specialized tool for research focused on the CD279 protein, commonly known as PD-1, a crucial immune checkpoint receptor involved in regulating T-cell responses. This monoclonal antibody, produced with high specificity, is optimized for detecting and studying the expression and function of PD-1 in human samples. Validated for various applications including flow cytometry and immunohistochemistry, it enables precise analysis of PD-1 expression in different cell types and tissues. PD-1 plays a key role in immune tolerance and modulation, exerting a significant impact on immune responses by inhibiting T-cell activation and preventing autoimmunity.

Its dysregulation is associated with various diseases, particularly cancer, making PD-1 a prime target for therapeutic interventions such as immune checkpoint blockade. Investigating the mechanisms and interactions involving PD-1 is essential for unraveling its potential in cancer immunotherapy and other immune-related disorders, guiding the development of innovative treatment strategies.

Product Title:Low Endotoxin Purified Anti-Human CD279/PD-1 Antibody [J116]
SKU:AGEL1606
Size:50µg, 500µg, 1mg
Clone No:J116
Synonyms:PD-1; Programmed Death-1;
Host Species:Mouse
Reactivity:Human
Application:FCM;Block;Neut
Isotype:Mouse IgG1, κ
Isotype Control:AF/LE Purified Mouse IgG1, κ Isotype Control[MOPC-21]
Form:Liquid
Conjugation:None (AF/LE)
Recommended Use:Each lot of this antibody is quality control tested by flow cytometric analysis. For flow cytometric staining, the suggested use of this reagent is ≤ 1.0 µg per 106 cells in 100 µL volume or 100 µL of whole blood. It is recommended that the reagent be titrated for optimal performance for each application.
Swissprot:Q15116
Gene ID:5133
Storage Buffer:0.2 μm filtered in PBS, pH 7.2. Azide Free (AF)/Low Endotoxin (LE): Contains no stabilizers or stabilizers. Endotoxin level is < 2 EU/mg as Determined by LAL gel clotting assay.
Stability & Storage:Keep as concentrated solution. Store at 2~8°C and protected from prolonged exposure to light. Do not freeze. Centrifuge before opening to ensure complete recovery of vial contents. This product is guaranteed up to one year from purchase.
Background:Programmed cell death 1 (PD-1), also known as CD279, is a 55 kD member of the immunoglobulin superfamily. CD279 contains the immunoreceptor tyrosine-based inhibitory motif (ITIM) in the cytoplasmic region and plays a key role in peripheral tolerance and autoimmune disease. CD279 is expressed predominantly on activated T cells, B cells, and myeloid cells. PD-L1 (B7-H1) and PD-L2 (B7-DC) are ligands of CD279 (PD-1) and are members of the B7 gene family. Evidence suggests overlapping functions for these two PD-1 ligands and their constitutive expression on some normal tissues and upregulation on activated antigen-presenting cells. Interaction of CD279 ligands results in inhibition of T cell proliferation and cytokine secretion.

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