Low Endotoxin Purified Anti-Human CD279/PD-1 Antibody [J110] (AGEL2093)

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SKU:
AGEL2093
Product Type:
Antibody
Antibody Type:
Monoclonal Antibody
Reactivity:
Human
Applications:
FC
Frequently bought together:

Description

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Low Endotoxin Purified Anti-Human CD279/PD-1 Antibody [J110]

The AF-Le Purified Human CD279 (PD-1) Monoclonal Antibody (J110) is a cutting-edge tool for researchers investigating the PD-1 protein, a key checkpoint receptor in the immune system. This monoclonal antibody, meticulously crafted for precision and reliability, is specifically engineered to target and detect PD-1 in human samples. Validated for a wide range of applications, including flow cytometry and immunohistochemistry, this antibody provides unparalleled sensitivity and specificity in PD-1 analysis.PD-1, recognized for its role in immune regulation and tolerance, acts as a critical modulator of T cell activity and is integral in maintaining self-tolerance and preventing autoimmunity. Its significance in immune checkpoint pathways has positioned PD-1 as a key target in cancer immunotherapy, where its blockade has shown promising results in restoring anti-tumor immune responses.

Studies involving PD-1 are pivotal in unraveling the complexities of immune evasion mechanisms employed by cancer cells and are essential in developing innovative therapeutic strategies to enhance immune-mediated anti-cancer effects.By utilizing the AF-Le Purified Human CD279 (PD-1) Monoclonal Antibody (J110), researchers can delve deeper into the intricate interplay between PD-1 and the immune system, opening new avenues for understanding immune dysfunction in various diseases, particularly cancer. This antibody serves as a valuable asset in elucidating the mechanisms underlying immune evasion and holds immense potential in driving advancements in immunotherapy and precision medicine.

Product Title:Low Endotoxin Purified Anti-Human CD279/PD-1 Antibody [J110]
SKU:AGEL2093
Size:50µg, 500µg, 1mg
Clone No:J110
Synonyms:PDCD1;PD1;Protein PD-1;hPD-1;
Host Species:Mouse
Reactivity:Human
Application:FCM
Isotype:Mouse IgG1, κ
Isotype Control:AF/LE Purified Mouse IgG1, κ Isotype Control[MOPC-21]
Form:Liquid
Conjugation:None (AF/LE)
Recommended Use:Each lot of this antibody is quality control tested by flow cytometric analysis. For flow cytometric staining, the suggested use of this reagent is ≤ 2.0 µg per 106 cells in 100 µL volume or 100 µL of whole blood. It is recommended that the reagent be titrated for optimal performance for each application.
Swissprot:Q15116
Gene ID:5133
Storage Buffer:0.2 μm filtered in PBS, pH 7.2. Azide Free (AF)/Low Endotoxin (LE): Contains no stabilizers or stabilizers. Endotoxin level is < 2 EU/mg as Determined by LAL gel clotting assay.
Stability & Storage:Keep as concentrated solution. Store at 2~8°C and protected from prolonged exposure to light. Do not freeze. Centrifuge before opening to ensure complete recovery of vial contents. This product is guaranteed up to one year from purchase.
Background:Programmed cell death 1 (PD-1), also known as CD279, is a 55 kD member of the immunoglobulin superfamily. CD279 contains the immunoreceptor tyrosine-based inhibitory motif (ITIM) in the cytoplasmic region and plays a key role in peripheral tolerance and autoimmune disease. CD279 is expressed predominantly on activated T cells, B cells, and myeloid cells. PD-L1 and PD-L2 are ligands of CD279 (PD-1) and are members of the B7 gene family. Evidence suggests overlapping functions for these two PD-1 ligands and their constitutive expression on some normal tissues and upregulation on activated antigen-presenting cells. Interaction of CD279 ligands results in inhibition of T cell proliferation and cytokine secretion.

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