The Purified Human CD20 Monoclonal Antibody 2H7 (AGEL2092) offered by Assay Genie is a cutting-edge tool for researchers investigating CD20, a cell surface protein prevalent on B cells. This monoclonal antibody, rigorously purified and optimized for human samples, is a reliable choice for a range of applications in immunology and oncology studies.CD20, a key marker for B-cell identification, is a target of interest in cancer therapy, particularly in the treatment of B-cell malignancies such as lymphoma and leukemia. The 2H7 monoclonal antibody binds specifically to the CD20 molecule, facilitating its detection and analysis in various experimental settings.
Its high specificity and sensitivity make it an invaluable asset for researchers exploring the role of CD20 in immune responses and malignancies.By utilizing the Purified Human CD20 Monoclonal Antibody 2H7 (AGEL2092), scientists can delve deeper into the functions and implications of CD20 in health and disease. With its proven performance and application versatility, this monoclonal antibody enables precise and meaningful investigation into the role of CD20 in immune system regulation and cancer development.
Each lot of this antibody is quality control tested by flow cytometric analysis. For flow cytometric staining, the suggested use of this reagent is ≤ 2.0 µg per 106 cells in 100 µL volume or 100 µL of whole blood. It is recommended that the reagent be titrated for optimal performance for each application.
Swissprot:
P11836
Gene ID:
931
Storage Buffer:
0.2 μm filtered in PBS, pH 7.2. Azide Free (AF)/Low Endotoxin (LE): Contains no stabilizers or stabilizers. Endotoxin level is < 2 EU/mg as Determined by LAL gel clotting assay.
Stability & Storage:
Keep as concentrated solution. Store at 2~8°C and protected from prolonged exposure to light. Do not freeze. Centrifuge before opening to ensure complete recovery of vial contents. This product is guaranteed up to one year from purchase.
Background:
CD20 is a 33-37 kD, four transmembrane spanning protein, also known as B1 and Bp35. CD20 is expressed on pre-B-cells, resting and activated B cells (not plasma cells), some follicular dendritic cells, and at low levels on a T cell subset. CD20 is heavily phosphorylated on activated B cells and malignant B cells. Homo-oligomeric complexes of CD20 are thought to form Ca2+ conductive ion channels in the plasma membrane of B cells. The CD20 molecule is involved in B-cell activation and is associated with various Src family kinases (Lyn, Lck, Fyn). It exists in a complex with MHC class I and II, CD53, CD81, and CD82.
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