ADORA3 Antibody (PACO23513)
- SKU:
- PACO23513
- Product type:
- Antibody
- Reactivity:
- Human
- Mouse
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Application:
- ELISA
- Application:
- WB
- Application:
- IHC
- Antibody type:
- Polyclonal
- Conjugation:
- Unconjugated
Frequently bought together:
Description
| Antibody Name: | ADORA3 Antibody (PACO23513) |
| Antibody SKU: | PACO23513 |
| Size: | 100ul |
| Host Species: | Rabbit |
| Tested Applications: | ELISA, WB, IHC |
| Recommended Dilutions: | ELISA:1:2000-1:10000, WB:1:500-1:3000, IHC:1:50-1:100 |
| Species Reactivity: | Human, Mouse, Rat |
| Immunogen: | Fusion protein corresponding to a region derived from internal residues of human Adenosine receptor A3 |
| Form: | Liquid |
| Storage Buffer: | Rabbit IgG in pH7.3 PBS, 0.05% NaN3, 50% Glycerol. |
| Purification Method: | Antigen Affinity Purified |
| Clonality: | Polyclonal |
| Isotype: | IgG |
| Conjugate: | Non-conjugated |
 | Gel: 10%SDS-PAGE Lysates (from left to right): Mouse testis tissue Amount of lysate: 20ug per lane Primary antibody: 1/100 dilution Secondary antibody dilution: 1/8000 Exposure time: 1 minute. |
 | Immunohistochemical analysis of paraffin-embedded Human esophagus cancer tissue using at dilution 1/20. |
| Background: | This gene encodes a protein that belongs to the family of adenosine receptors, which are G-protein-coupled receptors that are involved in a variety of intracellular signaling pathways and physiological functions. The receptor encoded by this gene mediates a sustained cardioprotective function during cardiac ischemia, it is involved in the inhibition of neutrophil degranulation in neutrophil-mediated tissue injury, it has been implicated in both neuroprotective and neurodegenerative effects, and it may also mediate both cell proliferation and cell death. Multiple transcript variants encoding different isoforms have been found for this gene. |
| Synonyms: | A3AR; AD026 |
| UniProt Protein Function: | ADORA3: Receptor for adenosine. The activity of this receptor is mediated by G proteins which inhibits adenylyl cyclase. Possible role in reproduction. Belongs to the G-protein coupled receptor 1 family. 3 isoforms of the human protein are produced by alternative splicing.Protein type: Receptor, GPCR; GPCR, family 1; Membrane protein, integral; Membrane protein, multi-passChromosomal Location of Human Ortholog: 1p13.2Cellular Component: mast cell granule; integral to plasma membrane; plasma membraneMolecular Function: adenosine receptor activity, G-protein coupledBiological Process: positive regulation of phosphoinositide 3-kinase cascade; histamine secretion by mast cell; positive regulation of leukocyte migration; adenylate cyclase activation; response to wounding; positive regulation of mast cell degranulation; positive regulation of calcium-mediated signaling; signal transduction; inflammatory response; adenosine receptor signaling pathway; regulation of heart contraction; positive regulation of inflammatory response |
| UniProt Protein Details: | |
| NCBI Summary: | This gene encodes a protein that belongs to the family of adenosine receptors, which are G-protein-coupled receptors that are involved in a variety of intracellular signaling pathways and physiological functions. The receptor encoded by this gene mediates a sustained cardioprotective function during cardiac ischemia, it is involved in the inhibition of neutrophil degranulation in neutrophil-mediated tissue injury, it has been implicated in both neuroprotective and neurodegenerative effects, and it may also mediate both cell proliferation and cell death. Alternative splicing results in multiple transcript variants. This gene shares its 5' terminal exon with some transcripts from overlapping GeneID:57413, which encodes an immunoglobulin domain-containing protein. [provided by RefSeq, Nov 2014] |
| UniProt Code: | P33765 |
| NCBI GenInfo Identifier: | 1351831 |
| NCBI Gene ID: | 140 |
| NCBI Accession: | P33765.2 |
| UniProt Secondary Accession: | P33765,Q6UWU0, Q9BYZ1, A2A3P4 |
| UniProt Related Accession: | P33765 |
| Molecular Weight: | Calculated MW: 36kDaObserved MW: 37kDa |
| NCBI Full Name: | Adenosine receptor A3 |
| NCBI Synonym Full Names: | adenosine A3 receptor |
| NCBI Official Symbol: | ADORA3 |
| NCBI Official Synonym Symbols: | A3AR |
| NCBI Protein Information: | adenosine receptor A3 |
| UniProt Protein Name: | Adenosine receptor A3 |
| UniProt Synonym Protein Names: | |
| Protein Family: | Adenosine receptor |
| UniProt Gene Name: | ADORA3 |
| UniProt Entry Name: | AA3R_HUMAN |
Related Products
Rat Adenosine A3 Receptor / ADORA3 ELISA Kit
Human A3/ADORA3(Adenosine A3 Receptor) ELISA Kit
