| UniProt Protein Function: | ADAMTS12: Metalloprotease that may play a role in the degradation of COMP. Cleaves also alpha-2 macroglobulin and aggregan. Has anti-tumorigenic properties. 3 isoforms of the human protein are produced by alternative splicing. |
| UniProt Protein Details: | Protein type:EC 3.4.24.-; Motility/polarity/chemotaxis; Secreted; Secreted, signal peptide; Protease Chromosomal Location of Human Ortholog: 5q35 Cellular Component: extracellular matrix; proteinaceous extracellular matrix Molecular Function:protein binding; zinc ion binding; metalloendopeptidase activity Biological Process: cell migration; proteolysis involved in cellular protein catabolic process; cell-matrix adhesion; negative regulation of chondrocyte differentiation; regulation of inflammatory response; proteoglycan catabolic process |
| NCBI Summary: | This gene encodes a member of the ADAMTS (a disintegrin and metalloproteinase with thrombospondin motifs) protein family. Members of the family share several distinct protein modules, including a propeptide region, a metalloproteinase domain, a disintegrin-like domain, and a thrombospondin type 1 (TS-1) motif. Individual members of this family differ in the number of C-terminal TS-1 motifs, and some have unique C-terminal domains. The enzyme encoded by this gene contains eight TS-1 motifs. It may play roles in pulmonary cells during fetal development or in tumor processes through its proteolytic activity or as a molecule potentially involved in regulation of cell adhesion. [provided by RefSeq, Jul 2008] |
| UniProt Code: | P58397 |
| NCBI GenInfo Identifier: | 51558724 |
| NCBI Gene ID: | 81792 |
| NCBI Accession: | NP_112217.2 |
| UniProt Secondary Accession: | P58397,Q6UWL3, A2RRN9, A5D6V6, |
| UniProt Related Accession: | P58397 |
| Molecular Weight: | 168,460 Da |
| NCBI Full Name: | A disintegrin and metalloproteinase with thrombospondin motifs 12 preproprotein |
| NCBI Synonym Full Names: | ADAM metallopeptidase with thrombospondin type 1 motif, 12 |
| NCBI Official Symbol: | ADAMTS12 |
| NCBI Official Synonym Symbols: | PRO4389 |
| NCBI Protein Information: | A disintegrin and metalloproteinase with thrombospondin motifs 12 |
| UniProt Protein Name: | A disintegrin and metalloproteinase with thrombospondin motifs 12 |
| Protein Family: | Disintegrin and metalloproteinase domain-containing protein |
| UniProt Gene Name: | ADAMTS12 |
| UniProt Entry Name: | ATS12_HUMAN |
