| UniProt Protein Function: | ADAM19: Participates in the proteolytic processing of beta-type neuregulin isoforms which are involved in neurogenesis and synaptogenesis, suggesting a regulatory role in glial cell. Also cleaves alpha-2 macroglobulin. May be involved in osteoblast differentiation and/or osteoblast activity in bone. 2 isoforms of the human protein are produced by alternative splicing. |
| UniProt Protein Details: | Protein type:EC 3.4.24.-; Motility/polarity/chemotaxis; Membrane protein, integral; Protease Chromosomal Location of Human Ortholog: 5q33.3 Cellular Component: integral to membrane Molecular Function:zinc ion binding; metalloendopeptidase activity; SH3 domain binding Biological Process: heart development; membrane protein ectodomain proteolysis |
| NCBI Summary: | This gene encodes a member of the ADAM (a disintegrin and metalloprotease domain) family. Members of this family are membrane-anchored proteins structurally related to snake venom disintegrins and have been implicated in a variety of biological processes involving cell-cell and cell-matrix interactions, including fertilization, muscle development, and neurogenesis. This member is a type I transmembrane protein and serves as a marker for dendritic cell differentiation. It has been demonstrated to be an active metalloproteinase, which may be involved in normal physiological processes such as cell migration, cell adhesion, cell-cell and cell-matrix interactions, and signal transduction. It is proposed to play a role in pathological processes, such as cancer, inflammatory diseases, renal diseases, and Alzheimer's disease. [provided by RefSeq, May 2013] |
| UniProt Code: | Q9H013 |
| NCBI GenInfo Identifier: | 302393821 |
| NCBI Gene ID: | 8728 |
| NCBI Accession: | Q9H013.3 |
| UniProt Secondary Accession: | Q9H013,Q9BZL5, Q9UHP2, |
| UniProt Related Accession: | Q9H013 |
| Molecular Weight: | 100,848 Da |
| NCBI Full Name: | Disintegrin and metalloproteinase domain-containing protein 19 |
| NCBI Synonym Full Names: | ADAM metallopeptidase domain 19 |
| NCBI Official Symbol: | ADAM19 |
| NCBI Official Synonym Symbols: | MLTNB; FKSG34; MADDAM |
| NCBI Protein Information: | disintegrin and metalloproteinase domain-containing protein 19; ADAM 19; meltrin-beta; metalloprotease-disintegrin meltrin beta; metalloprotease and disintegrin dendritic antigen marker; a disintegrin and metalloproteinase domain 19 (meltrin beta) |
| UniProt Protein Name: | Disintegrin and metalloproteinase domain-containing protein 19 |
| UniProt Synonym Protein Names: | Meltrin-beta; Metalloprotease and disintegrin dendritic antigen marker; MADDAM |
| Protein Family: | Disintegrin and metalloproteinase domain-containing protein |
| UniProt Gene Name: | ADAM19 |
| UniProt Entry Name: | ADA19_HUMAN |
