Activin proteins that belong to the transforming growth factor-beta (TGF-β) superfamily; exert their biological actions by binding to heteromeric receptor complexes of type I and type II serine/threonine kinase receptors. On ligand binding; type I and II receptors form a stable complex; resulting in phosphorylation of type I receptors by type II receptors with constitutive kinase activity; and subsequently initiates the activation of downstream molecules including the endogenous Smads. ActRIIB; also known as ActRIIB; is a type II receptor containing an extracellular domain (ECD); a transmembrane segment; and a cytoplasmic region that includes the kinase domain. ActRIIB is a receptor for activin A; activin B and inhibin A. Multiple ActRIIB isoforms can also be generated; which bind activin isoforms with different affinities.
Product Name:
Activin Receptor 2B/ACVR2B Recombinant Protein (RPES2019)
Product Code:
RPES2019
Size:
10µg
Species:
Human
Expressed Host:
Human Cells
Synonyms:
Activin Receptor Type-2B, Activin Receptor Type IIB, ACTR-IIB, ACVR2B,Bone Morphogenetic Protein Receptor Type-2, BMP Type-2 Receptor, BMPR-3, Bone Morphogenetic Protein Receptor Type II, BMP Type II Receptor
Accession:
Q13705
Sequence:
Ser19-Thr134
Fusion tag:
C-Fc-6His
Activity:
Immobilized Human/Mouse/Rat Activin A(Cat: PKSH033807) at 5µg/ml(100 ?l/well) can bind Human ACVR2B-His. The ED50 of Human ACVR2B-His is 20.58 ng/ml .
Endotoxin:
<1.0 EU per µg as determined by the LAL method.
Protein Construction:
Recombinant Human Activin Receptor Type 2B is produced by our Mammalian expression system and the target gene encoding Ser19-Thr134 is expressed with a Fc; 6His tag at the C-terminus.
Purity:
> 95 % as determined by reducing SDS-PAGE.
Mol Mass:
41.3 kDa
AP Mol Mass:
60 kDa
Formulation:
Lyophilized from a 0.2 µm filtered solution of 20mM PB;150mM NaCl;pH7.4.
Shipping:
This product is provided as lyophilized powder which is shipped with ice packs.
Stability and Storage:
Lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.
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