AADACL2 Antibody (PACO15217)
- SKU:
- PACO15217
- Product type:
- Antibody
- Reactivity:
- Human
- Host Species:
- Rabbit
- Isotype:
- IgG
- Application:
- ELISA
- Application:
- IHC
- Antibody type:
- Polyclonal
- Conjugation:
- Unconjugated
Frequently bought together:
Description
| Antibody Name: | AADACL2 Antibody (PACO15217) |
| Antibody SKU: | PACO15217 |
| Size: | 50ul |
| Host Species: | Rabbit |
| Tested Applications: | ELISA, IHC |
| Recommended Dilutions: | ELISA:1:2000-1:5000, IHC:1:25-1:100 |
| Species Reactivity: | Human |
| Immunogen: | Fusion protein of human AADACL2 |
| Form: | Liquid |
| Storage Buffer: | -20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol |
| Purification Method: | Antigen affinity purification |
| Clonality: | Polyclonal |
| Isotype: | IgG |
| Conjugate: | Non-conjugated |
 | The image on the left is immunohistochemistry of paraffin-embedded Human thyroid cancer tissue using PACO15217(AADACL2 Antibody) at dilution 1/25, on the right is treated with fusion protein. (Original magnification: x200). |
 | The image on the left is immunohistochemistry of paraffin-embedded Human colon cancer tissue using PACO15217(AADACL2 Antibody) at dilution 1/25, on the right is treated with fusion protein. (Original magnification: x200). |
| Background: | AADAC is a 45 kDa membrane-associated hydrolase highly expressed in the human liver that has been implicated in the hydrolysis of arylacetamide xenobiotics including flutamide and phenacetin.556–560AADAC is highly homologous to several related lipases, AADACL1, 2, and 4, the latter two of which remain completely unannotated. Overexpression of AADAC in a rat hepatoma cell line produces changes in cellular TG levels, apoplipoprotein B secretion, and fatty acid, oxidation, but the mechanism for these effects remains unclear.561 Candidate endogenous substrates, selective inhibitors, or knockout mice have not, to our knowledge, been described for AADAC or the related enzymes AADACL2 and AADACL4. |
| Synonyms: | arylacetamide deacetylase-like 2 |
| UniProt Protein Function: | AADACL2: Belongs to the 'GDXG' lipolytic enzyme family. 2 isoforms of the human protein are produced by alternative splicing.Protein type: Secreted, signal peptide; Hydrolase; Secreted; EC 3.1.1.-Chromosomal Location of Human Ortholog: 3q25.1 |
| UniProt Protein Details: | |
| NCBI Summary: | |
| UniProt Code: | Q6P093 |
| NCBI GenInfo Identifier: | 269849709 |
| NCBI Gene ID: | 344752 |
| NCBI Accession: | Q6P093.3 |
| UniProt Secondary Accession: | Q6P093,Q5HYJ4 |
| UniProt Related Accession: | Q6P093 |
| Molecular Weight: | |
| NCBI Full Name: | Arylacetamide deacetylase-like 2 |
| NCBI Synonym Full Names: | arylacetamide deacetylase like 2 |
| NCBI Official Symbol: | AADACL2 |
| NCBI Official Synonym Symbols: | |
| NCBI Protein Information: | arylacetamide deacetylase-like 2 |
| UniProt Protein Name: | Arylacetamide deacetylase-like 2 |
| UniProt Synonym Protein Names: | |
| Protein Family: | Arylacetamide deacetylase |
| UniProt Gene Name: | AADACL2 |
| UniProt Entry Name: | ADCL2_HUMAN |
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