ZFYVE9 Antibody (PACO63391)
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주문- SKU:
- PACO63391
- Product type:
- Antibody
- Reactivity:
- Human
- Host Species:
- Rabbit
- Isotype:
- IgG
- Application:
- ELISA
- Application:
- WB
- Application:
- IF
- Antibody type:
- Polyclonal
- Conjugation:
- Unconjugated
Frequently bought together:
Description
Antibody Name: | ZFYVE9 Antibody (PACO63391) |
Antibody SKU: | PACO63391 |
Size: | 50ul |
Host Species: | Rabbit |
Tested Applications: | ELISA, WB, IF |
Recommended Dilutions: | ELISA:1:2000-1:10000, WB:1:500-1:2000, IF:1:50-1:200 |
Species Reactivity: | Human |
Immunogen: | Recombinant Human Zinc finger FYVE domain-containing protein 9 protein (683-926AA) |
Form: | Liquid |
Storage Buffer: | Preservative: 0.03% Proclin 300 Constituents: 50% Glycerol, 0.01M PBS, pH 7.4 |
Purification Method: | Antigen Affinity Purified |
Clonality: | Polyclonal |
Isotype: | IgG |
Conjugate: | Non-conjugated |
![]() | Western Blot. Positive WB detected in: Hela whole cell lysate, MCF-7 whole cell lysate, L02 whole cell lysate, U87 whole cell lysate, HepG2 whole cell lysate. All lanes: ZFYVE9 antibody at 1:1000. Secondary. Goat polyclonal to rabbit IgG at 1/50000 dilution. Predicted band size: 157, 151, 84 kDa. Observed band size: 157 kDa. |
![]() | Immunofluorescence staining of HepG2 cells with PACO63391 at 1:50, counter-stained with DAPI. The cells were fixed in 4% formaldehyde, permeabilized using 0.2% Triton X-100 and blocked in 10% normal Goat Serum. The cells were then incubated with the antibody overnight at 4°C. The secondary antibody was Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L). |
Background: | Early endosomal protein that functions to recruit SMAD2/SMAD3 to intracellular membranes and to the TGF-β receptor. Plays a significant role in TGF-mediated signaling by regulating the subcellular location of SMAD2 and SMAD3 and modulating the transcriptional activity of the SMAD3/SMAD4 complex. Possibly associated with TGF-β receptor internalization. |
Synonyms: | Zinc finger FYVE domain-containing protein 9 (Mothers against decapentaplegic homolog-interacting protein) (Madh-interacting protein) (Novel serine protease) (NSP) (Receptor activation anchor) (hSARA) (Smad anchor for receptor activation), ZFYVE9, MADHIP SARA SMADIP |
UniProt Protein Function: | Early endosomal protein that functions to recruit SMAD2/SMAD3 to intracellular membranes and to the TGF-beta receptor. Plays a significant role in TGF-mediated signaling by regulating the subcellular location of SMAD2 and SMAD3 and modulating the transcriptional activity of the SMAD3/SMAD4 complex. Possibly associated with TGF-beta receptor internalization. |
NCBI Summary: | This gene encodes a double zinc finger motif-containing protein that participates in the transforming growth factor-beta (TGFB) signalling pathway. The encoded protein interacts directly with SMAD2 and SMAD3, and recruits SMAD2 to the TGFB receptor. There are multiple pseudogenes for this gene on chromosomes 2, 15, and X. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Mar 2013] |
UniProt Code: | O95405 |
NCBI GenInfo Identifier: | 47717106 |
NCBI Gene ID: | 9372 |
NCBI Accession: | NP_004790.2 |
UniProt Secondary Accession: | O95405,Q5T0F6, Q5T0F7, Q9UNE1, Q9Y5R7, |
UniProt Related Accession: | O95405 |
Molecular Weight: | 83,721 Da |
NCBI Full Name: | zinc finger FYVE domain-containing protein 9 isoform 3 |
NCBI Synonym Full Names: | zinc finger FYVE-type containing 9 |
NCBI Official Symbol: | ZFYVE9 |
NCBI Official Synonym Symbols: | NSP; SARA; MADHIP; SMADIP; PPP1R173 |
NCBI Protein Information: | zinc finger FYVE domain-containing protein 9 |
UniProt Protein Name: | Zinc finger FYVE domain-containing protein 9 |
UniProt Synonym Protein Names: | Mothers against decapentaplegic homolog-interacting protein; Madh-interacting protein; Novel serine protease; NSP; Receptor activation anchor; hSARA; Smad anchor for receptor activation |
Protein Family: | Sarafotoxin |
UniProt Gene Name: | ZFYVE9 |