Background: | autophagosome, endoplasmic reticulum, ER-mitochondrion membrane contact site, extrinsic component of omegasome membrane, Golgi stack, perinuclear region of cytoplasm, pre-autophagosomal structure, 1-phosphatidylinositol binding, phosphatidylinositol-3,4,5-trisphosphate binding, phosphatidylinositol-3,4-bisphosphate binding |
Synonyms: | Zinc finger FYVE domain-containing protein 1 (Double FYVE-containing protein 1) (SR3) (Tandem FYVE fingers-1), ZFYVE1, DFCP1 KIAA1589 TAFF1 ZNFN2A1 |
UniProt Protein Function: | ZFYVE1: 2 isoforms of the human protein are produced by alternative splicing. |
UniProt Protein Details: | Protein type:Vesicle Chromosomal Location of Human Ortholog: 14q24.2 Cellular Component: autophagic vacuole; endoplasmic reticulum; Golgi stack; membrane; perinuclear region of cytoplasm Molecular Function:phosphatidylinositol binding; phosphatidylinositol-3,4,5-triphosphate binding; phosphatidylinositol-3,4-bisphosphate binding; protein binding Biological Process: cellular response to starvation; macroautophagy |
NCBI Summary: | The FYVE domain mediates the recruitment of proteins involved in membrane trafficking and cell signaling to phosphatidylinositol 3-phosphate-containing membranes. This protein contains two zinc-binding FYVE domains in tandem and is reported to localize to the Golgi apparatus. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2013] |
UniProt Code: | Q9HBF4 |
NCBI GenInfo Identifier: | 34098716 |
NCBI Gene ID: | 53349 |
NCBI Accession: | Q9HBF4.1 |
UniProt Secondary Accession: | Q9HBF4,Q8WYX7, Q96K57, Q9BXP9, Q9HCI3, J3KNL9, |
UniProt Related Accession: | Q9HBF4 |
Molecular Weight: | 85,592 Da |
NCBI Full Name: | Zinc finger FYVE domain-containing protein 1 |
NCBI Synonym Full Names: | zinc finger FYVE-type containing 1 |
NCBI Official Symbol: | ZFYVE1 |
NCBI Official Synonym Symbols: | SR3; DFCP1; TAFF1; ZNFN2A1; PPP1R172 |
NCBI Protein Information: | zinc finger FYVE domain-containing protein 1 |
UniProt Protein Name: | Zinc finger FYVE domain-containing protein 1 |
UniProt Synonym Protein Names: | Double FYVE-containing protein 1; SR3; Tandem FYVE fingers-1 |
Protein Family: | Zinc finger FYVE domain-containing protein |
UniProt Gene Name: | ZFYVE1 |
UniProt Entry Name: | ZFYV1_HUMAN |