UniProt Protein Function: | XIAP: an apoptotic suppressor protein. Inhibist apoptosis through binding to tumor necrosis factor receptor-associated factors TRAF1 and TRAF2. Inhibits apoptosis induced by menadione, a potent inducer of free radicals, and ICE. Inhibits cell-death proteases, caspase-3, caspase-7, and perhaps caspase-9. |
UniProt Protein Details: | Protein type:EC 6.3.2.-; Apoptosis; Ubiquitin ligase; Ubiquitin conjugating system; Ligase Chromosomal Location of Human Ortholog: Xq25 Cellular Component: nucleoplasm; spindle microtubule; cytoplasm; nucleus; cytosol Molecular Function:protein binding; zinc ion binding; caspase inhibitor activity; ubiquitin-protein ligase activity; ligase activity Biological Process: Wnt receptor signaling pathway; positive regulation of protein ubiquitination; apoptosis; regulation of inflammatory response; regulation of BMP signaling pathway; protein ubiquitination; negative regulation of caspase activity; response to DNA damage stimulus; copper ion homeostasis; regulation of cell proliferation; negative regulation of apoptosis; regulation of innate immune response Disease: Lymphoproliferative Syndrome, X-linked, 1; Lymphoproliferative Syndrome, X-linked, 2 |
NCBI Summary: | This gene encodes a protein that belongs to a family of apoptotic suppressor proteins. Members of this family share a conserved motif termed, baculovirus IAP repeat, which is necessary for their anti-apoptotic function. This protein functions through binding to tumor necrosis factor receptor-associated factors TRAF1 and TRAF2 and inhibits apoptosis induced by menadione, a potent inducer of free radicals, and interleukin 1-beta converting enzyme. This protein also inhibits at least two members of the caspase family of cell-death proteases, caspase-3 and caspase-7. Mutations in this gene are the cause of X-linked lymphoproliferative syndrome. Alternate splicing results in multiple transcript variants. Pseudogenes of this gene are found on chromosomes 2 and 11.[provided by RefSeq, Feb 2011] |
UniProt Code: | P98170 |
NCBI GenInfo Identifier: | 12643387 |
NCBI Gene ID: | 331 |
NCBI Accession: | P98170.2 |
UniProt Secondary Accession: | P98170,Q9NQ14, D3DTF2, |
UniProt Related Accession: | P98170 |
Molecular Weight: | 497 |
NCBI Full Name: | E3 ubiquitin-protein ligase XIAP |
NCBI Synonym Full Names: | X-linked inhibitor of apoptosis, E3 ubiquitin protein ligase |
NCBI Official Symbol: | XIAP |
NCBI Official Synonym Symbols: | API3; ILP1; MIHA; XLP2; BIRC4; IAP-3; hIAP3; hIAP-3 |
NCBI Protein Information: | E3 ubiquitin-protein ligase XIAP; X-linked IAP; IAP-like protein; inhibitor of apoptosis protein 3; baculoviral IAP repeat-containing protein 4 |
UniProt Protein Name: | E3 ubiquitin-protein ligase XIAP |
UniProt Synonym Protein Names: | Baculoviral IAP repeat-containing protein 4; IAP-like protein; ILP; hILP; Inhibitor of apoptosis protein 3; IAP-3; hIAP-3; hIAP3; X-linked inhibitor of apoptosis protein; X-linked IAP |
Protein Family: | XIAP-associated factor |
UniProt Gene Name: | XIAP |
UniProt Entry Name: | XIAP_HUMAN |