WIPF1 Antibody (PACO22690)
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주문- SKU:
- PACO22690
- Product type:
- Antibody
- Reactivity:
- Human
- Host Species:
- Rabbit
- Isotype:
- IgG
- Application:
- ELISA
- Application:
- WB
- Antibody type:
- Polyclonal
- Conjugation:
- Unconjugated
Frequently bought together:
Description
Antibody Name: | WIPF1 Antibody (PACO22690) |
Antibody SKU: | PACO22690 |
Size: | 100ul |
Host Species: | Rabbit |
Tested Applications: | ELISA, WB |
Recommended Dilutions: | ELISA:1:2000-1:10000, WB:1:500-1:3000 |
Species Reactivity: | Human |
Immunogen: | Synthesized peptide derived from C-terminal of human WIPF1. |
Form: | Liquid |
Storage Buffer: | Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. |
Purification Method: | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
Clonality: | Polyclonal |
Isotype: | IgG |
Conjugate: | Non-conjugated |
Western blot analysis of extracts from K562 cells, using WIPF1 antibody. |
Background: | Plays a role in the reorganization of the actin cytoskeleton. Contributes with NCK1 and GRB2 in the recruitment and activation of WASL. May participate in regulating the subcellular localization of WASL, resulting in the disassembly of stress fibers in favor of filopodia formation. Plays a role in the formation of cell ruffles By similarity. Plays an important role in the intracellular motility of vaccinia virus by functioning as an adapter for recruiting WASL to vaccinia virus. |
Synonyms: | WAS/WASL-interacting protein family member 1; Wiskott-Aldrich syndrome protein-interacting protein; WASP-interacting protein; PRPL-2 protein; WIPF1 |
UniProt Protein Function: | WIPF1: a cytoskeleton-associated protein that interacts with the Wiskott-Aldrich syndrome protein (WASP) in resting cells. Plays an important role in the organization of the actin cytoskeleton. Phosphorylation by PKC-theta following T cell receptor signaling disengages it from WASP, releasing WASP from WIP inhibition. Binds to a region of WASP that is frequently mutated in Wiskott-Aldrich syndrome. |
UniProt Protein Details: | Protein type:Motility/polarity/chemotaxis; Actin-binding Chromosomal Location of Human Ortholog: 2q31.1 Cellular Component: actin cytoskeleton; actin filament; cytoplasmic membrane-bound vesicle; cytosol; ruffle Molecular Function:actin binding; actin filament binding; profilin binding; protein binding Biological Process: actin cortical patch assembly; actin cortical patch localization; actin filament-based movement; actin polymerization and/or depolymerization; endocytosis; innate immune response; positive regulation of actin nucleation; protein complex assembly; regulation of cell shape; response to other organism; small GTPase mediated signal transduction Disease: Wiskott-aldrich Syndrome 2 |
NCBI Summary: | This gene encodes a protein that plays an important role in the organization of the actin cytoskeleton. The encoded protein binds to a region of Wiskott-Aldrich syndrome protein that is frequently mutated in Wiskott-Aldrich syndrome, an X-linked recessive disorder. Impairment of the interaction between these two proteins may contribute to the disease. Two transcript variants encoding the same protein have been identified for this gene. [provided by RefSeq, Jul 2008] |
UniProt Code: | O43516 |
NCBI GenInfo Identifier: | 313104260 |
NCBI Gene ID: | 7456 |
NCBI Accession: | O43516.3 |
UniProt Secondary Accession: | O43516,Q15220, Q53TA9, Q6MZU9, Q9BU37, Q9UNP1, B8ZZM1 D3DPE4, |
UniProt Related Accession: | O43516 |
Molecular Weight: | 36,426 Da |
NCBI Full Name: | WAS/WASL-interacting protein family member 1 |
NCBI Synonym Full Names: | WAS/WASL interacting protein family member 1 |
NCBI Official Symbol: | WIPF1 |
NCBI Official Synonym Symbols: | WIP; WAS2; PRPL-2; WASPIP |
NCBI Protein Information: | WAS/WASL-interacting protein family member 1 |
UniProt Protein Name: | WAS/WASL-interacting protein family member 1 |
UniProt Synonym Protein Names: | Protein PRPL-2; Wiskott-Aldrich syndrome protein-interacting protein; WASP-interacting protein |
Protein Family: | WAS/WASL-interacting protein family |
UniProt Gene Name: | WIPF1 |
UniProt Entry Name: | WIPF1_HUMAN |