WDR5 Antibody (PACO43081)
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주문- SKU:
- PACO43081
- Product type:
- Antibody
- Reactivity:
- Human
- Host Species:
- Rabbit
- Isotype:
- IgG
- Application:
- ELISA
- Application:
- WB
- Application:
- IHC
- Antibody type:
- Polyclonal
- Conjugation:
- Unconjugated
Frequently bought together:
Description
Antibody Name: | WDR5 Antibody (PACO43081) |
Antibody SKU: | PACO43081 |
Size: | 50ul |
Host Species: | Rabbit |
Tested Applications: | ELISA, WB, IHC |
Recommended Dilutions: | ELISA:1:2000-1:10000, WB:1:200-1:1000, IHC:1:20-1:200 |
Species Reactivity: | Human |
Immunogen: | Recombinant Human WD repeat-containing protein 5 protein (1-334AA) |
Form: | Liquid |
Storage Buffer: | PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
Purification Method: | Antigen Affinity Purified |
Clonality: | Polyclonal |
Isotype: | IgG |
Conjugate: | Non-conjugated |
![]() | Western blot. All lanes: WDR5 antibody at 2µg/ml + A431 whole cell lysate. Secondary. Goat polyclonal to rabbit IgG at 1/10000 dilution. Predicted band size: 37 kDa. Observed band size: 37 kDa. |
![]() | Immunohistochemistry of paraffin-embedded human thyroid tissue using PACO43081 at dilution of 1:100. |
![]() | Immunohistochemistry of paraffin-embedded human breast tissue using PACO43081 at dilution of 1:100. |
Background: | Contributes to histone modification. May position the N-terminus of histone H3 for efficient trimethylation at 'Lys-4'. As part of the MLL1/MLL complex it is involved in methylation and dimethylation at 'Lys-4' of histone H3. H3 'Lys-4' methylation represents a specific tag for epigenetic transcriptional activation. As part of the NSL complex it may be involved in acetylation of nucleosomal histone H4 on several lysine residues. May regulate osteoblasts differentiation. |
Synonyms: | WD repeat-containing protein 5 (BMP2-induced 3-kb gene protein), WDR5, BIG3 |
UniProt Protein Function: | WDR5: a WD40 repeat protein. May accelerate osteoblast differentiation. Interacts with HCFC1. WD40 repeats are found in a number of eukaryotic proteins that coordinate multi-protein complex assemblies. WD40 proteins are implicated in many functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly. |
UniProt Protein Details: | Protein type:Adaptor/scaffold Chromosomal Location of Human Ortholog: 9q34 Cellular Component: histone acetyltransferase complex; histone methyltransferase complex; nucleoplasm; nucleus Molecular Function:histone acetyltransferase activity (H4-K16 specific); histone lysine N-methyltransferase activity (H3-K4 specific); histone-lysine N-methyltransferase activity; methylated histone residue binding; protein binding Biological Process: histone H3-K4 methylation |
NCBI Summary: | This gene encodes a member of the WD repeat protein family. WD repeats are minimally conserved regions of approximately 40 amino acids typically bracketed by gly-his and trp-asp (GH-WD), which may facilitate formation of heterotrimeric or multiprotein complexes. Members of this family are involved in a variety of cellular processes, including cell cycle progression, signal transduction, apoptosis, and gene regulation. This protein contains 7 WD repeats. Alternatively spliced transcript variants encoding the same protein have been identified. [provided by RefSeq, Jul 2008] |
UniProt Code: | P61964 |
NCBI GenInfo Identifier: | 48429182 |
NCBI Gene ID: | 11091 |
NCBI Accession: | P61964.1 |
UniProt Secondary Accession: | P61964,Q91VA5, Q9NWX7, Q9UGP9, |
UniProt Related Accession: | P61964 |
Molecular Weight: | 36,588 Da |
NCBI Full Name: | WD repeat-containing protein 5 |
NCBI Synonym Full Names: | WD repeat domain 5 |
NCBI Official Symbol: | WDR5 |
NCBI Official Synonym Symbols: | SWD3; BIG-3; CFAP89 |
NCBI Protein Information: | WD repeat-containing protein 5 |
UniProt Protein Name: | WD repeat-containing protein 5 |
UniProt Synonym Protein Names: | BMP2-induced 3-kb gene protein |
Protein Family: | WD repeat-containing protein |
UniProt Gene Name: | WDR5 |
UniProt Entry Name: | WDR5_HUMAN |