VSX1 Antibody (PACO45518)
제품 코드를 사용하여 Assay Genie 메인 사이트를 통해 주문합니다.
주문- SKU:
- PACO45518
- Product type:
- Antibody
- Reactivity:
- Human
- Host Species:
- Rabbit
- Isotype:
- IgG
- Application:
- ELISA
- Application:
- WB
- Antibody type:
- Polyclonal
- Conjugation:
- Unconjugated
Frequently bought together:
Description
Antibody Name: | VSX1 Antibody (PACO45518) |
Antibody SKU: | PACO45518 |
Size: | 50ul |
Host Species: | Rabbit |
Tested Applications: | ELISA, WB |
Recommended Dilutions: | ELISA:1:2000-1:10000, WB:1:1000-1:5000 |
Species Reactivity: | Human |
Immunogen: | Recombinant Human Visual system homeobox 1 protein (1-170AA) |
Form: | Liquid |
Storage Buffer: | PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
Purification Method: | Antigen Affinity Purified |
Clonality: | Polyclonal |
Isotype: | IgG |
Conjugate: | Non-conjugated |
![]() | Western blot. All lanes: VSX1 antibody IgG at 2.32µg/ml + 293T whole cell lysate. Secondary. Goat polyclonal to rabbit IgG at 1/10000 dilution. Predicted band size: 39, 25, 40, 15, 30, 23, 25, 33 kDa. Observed band size: 39 kDa.. |
Background: | Binds to the 37-bp core of the locus control region (LCR) of the red/green visual pigment gene cluster. May regulate the activity of the LCR and the cone opsin genes at earlier stages of development. |
Synonyms: | Visual system homeobox 1 (Homeodomain protein RINX) (Retinal inner nuclear layer homeobox protein) (Transcription factor VSX1), VSX1, RINX |
UniProt Protein Function: | VSX1: Binds to the 37-bp core of the locus control region (LCR) of the red/green visual pigment gene cluster. May regulate the activity of the LCR and the cone opsin genes at earlier stages of development. Defects in VSX1 are a cause of posterior polymorphous corneal dystrophy type 1 (PPCD1). PPCD1 is a slowly progressive hereditary disorder of the corneal endothelium that leads to a variable degree of visual impairment usually in adulthood. Defects in VSX1 are a cause of keratoconus type 1 (KTCN1). Keratoconus type 1 is a frequent corneal dystrophy with an incidence that varies from 50 to 230 per 100'000. The cornea assumes a conical shape as a result of a progressive non- inflammatory thinning of the corneal stroma. Keratoconus is most often an isolated sporadic condition with cases of autosomal dominant and autosomal recessive transmission. Defects in VSX1 are the cause of craniofacial anomalies and anterior segment dysgenesis syndrome (CAASDS). CAASDS is a disorder with extremely variable expressivity. Clinical features include wide interpupillary distance, abnormal corneal endothelium, unusual pinnae, partially to completely empty sella turcica, posterior fossa cyst, anterior encephalocele, and/or hydrocephalus. Belongs to the paired homeobox family. 8 isoforms of the human protein are produced by alternative splicing. |
UniProt Protein Details: | Protein type:Cell development/differentiation; DNA-binding Chromosomal Location of Human Ortholog: 20p11.21 Cellular Component: nucleus Molecular Function:chromatin binding Biological Process: neuron development; regulation of transcription, DNA-dependent Disease: Corneal Dystrophy, Posterior Polymorphous, 1; Craniofacial Anomalies And Anterior Segment Dysgenesis Syndrome; Keratoconus 1 |
NCBI Summary: | The protein encoded by this gene contains a paired-like homeodomain and binds to the core of the locus control region of the red/green visual pigment gene cluster. The encoded protein may regulate expression of the cone opsin genes early in development. Mutations in this gene can cause posterior polymorphous corneal dystrophy and keratoconus. Alternatively spliced transcript variants encoding different isoforms have been described. [provided by RefSeq, Jul 2008] |
UniProt Code: | Q9NZR4 |
NCBI GenInfo Identifier: | 25009572 |
NCBI Gene ID: | 30813 |
NCBI Accession: | Q9NZR4.2 |
UniProt Secondary Accession: | Q9NZR4,Q0GM60, Q0GM61, Q0GM62, Q0GM63, Q0GM64, Q0GM65 Q5TF40, Q5TF41, Q9HCU3, B9EGJ4, D1MF28, |
UniProt Related Accession: | Q9NZR4 |
Molecular Weight: | 38kDa |
NCBI Full Name: | Visual system homeobox 1 |
NCBI Synonym Full Names: | visual system homeobox 1 |
NCBI Official Symbol: | VSX1 |
NCBI Official Synonym Symbols: | PPD; KTCN; PPCD; RINX; KTCN1; PPCD1; CAASDS |
NCBI Protein Information: | visual system homeobox 1 |
UniProt Protein Name: | Visual system homeobox 1 |
UniProt Synonym Protein Names: | Homeodomain protein RINX; Retinal inner nuclear layer homeobox protein; Transcription factor VSX1 |
Protein Family: | Visual system homeobox |
UniProt Gene Name: | VSX1 |
Antibodies |
Anti-VSX1 Antibody (CAB9800) |
Secondary Antibody |
Anti-HRP Goat Anti-Rabbit IgG (H+L) Antibody (CABS014) |
Recommended Products |
Anti-FITC Goat Anti-Rabbit IgG (H+L) Antibody (CABS011) |
Anti-HRP-conjugated Beta Actin Antibody (CABC028) |