VPS36 Antibody (PACO63439)
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주문- SKU:
- PACO63439
- Product type:
- Antibody
- Reactivity:
- Human
- Host Species:
- Rabbit
- Isotype:
- IgG
- Application:
- ELISA
- Application:
- IHC
- Antibody type:
- Polyclonal
- Conjugation:
- Unconjugated
Frequently bought together:
Description
Antibody Name: | VPS36 Antibody (PACO63439) |
Antibody SKU: | PACO63439 |
Size: | 50ul |
Host Species: | Rabbit |
Tested Applications: | ELISA, IHC |
Recommended Dilutions: | ELISA:1:2000-1:10000, IHC:1:20-1:200 |
Species Reactivity: | Human |
Immunogen: | Peptide sequence from Human Vacuolar protein-sorting-associated protein 36 protein (87-105AA) |
Form: | Liquid |
Storage Buffer: | Preservative: 0.03% Proclin 300 Constituents: 50% Glycerol, 0.01M PBS, pH 7.4 |
Purification Method: | Antigen Affinity Purified |
Clonality: | Polyclonal |
Isotype: | IgG |
Conjugate: | Non-conjugated |
IHC image of PACO63439 diluted at 1:100 and staining in paraffin-embedded human small intestine tissue performed on a Leica BondTM system. After dewaxing and hydration, antigen retrieval was mediated by high pressure in a citrate buffer (pH 6.0). Section was blocked with 10% normal goat serum 30min at RT. Then primary antibody (1% BSA) was incubated at 4°C overnight. The primary is detected by a biotinylated secondary antibody and visualized using an HRP conjugated SP system. |
Background: | Component of the ESCRT-II complex (endosomal sorting complex required for transport II), which is required for multivesicular body (MVB) formation and sorting of endosomal cargo proteins into MVBs. The MVB pathway mediates delivery of transmembrane proteins into the lumen of the lysosome for degradation. The ESCRT-II complex is probably involved in the recruitment of the ESCRT-III complex. Its ability to bind ubiquitin probably plays a role in endosomal sorting of ubiquitinated cargo proteins by ESCRT complexes. The ESCRT-II complex may also play a role in transcription regulation, possibly via its interaction with ELL. Binds phosphoinosides such as PtdIns(3,4,5)P3. |
Synonyms: | Vacuolar protein-sorting-associated protein 36 (ELL-associated protein of 45 kDa) (ESCRT-II complex subunit VPS36), VPS36, C13orf9 EAP45 |
UniProt Code: | Q86VN1 |
NCBI GenInfo Identifier: | 71051598 |
NCBI Gene ID: | 51028 |
NCBI Accession: | NP_057159 |
UniProt Secondary Accession: | Q86VN1,Q3ZCV7, Q5H9S1, Q5VXB6, Q9H8Z5, Q9Y3E3, A8K125 |
UniProt Related Accession: | Q86VN1 |
Molecular Weight: | 36,958 Da |
NCBI Full Name: | vacuolar protein-sorting-associated protein 36 isoform 1 |
NCBI Synonym Full Names: | vacuolar protein sorting 36 homolog (S. cerevisiae) |
NCBI Official Symbol: | VPS36 |
NCBI Official Synonym Symbols: | EAP45; C13orf9; CGI-145 |
NCBI Protein Information: | vacuolar protein-sorting-associated protein 36; ELL-associated protein of 45 kDa; ESCRT-II complex subunit VPS36 |
UniProt Protein Name: | Vacuolar protein-sorting-associated protein 36 |
UniProt Synonym Protein Names: | ELL-associated protein of 45 kDa; ESCRT-II complex subunit VPS36 |
Protein Family: | Vacuolar protein sorting-associated protein |
UniProt Gene Name: | VPS36 |
UniProt Entry Name: | VPS36_HUMAN |
Antibodies |
Anti-VPS36 Antibody (CAB15157) |
Secondary Antibody |
Anti-HRP Goat Anti-Rabbit IgG (H+L) Antibody (CABS014) |
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Anti-FITC Goat Anti-Rabbit IgG (H+L) Antibody (CABS011) |
Anti-HRP-conjugated Beta Actin Antibody (CABC028) |