Vasopressin Recombinant Protein (RPPB1386)
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주문- SKU:
- RPPB1386
- Product type:
- Recombinant Protein
- Size:
- 25mg
- Target:
- Vasopressin
- Synonyms:
- Vasopressin-neurophysin 2-copeptin
- Synonyms:
- AVP-NPII
- Synonyms:
- VP
- Synonyms:
- ADH
- Uniprot:
- P01185
Description
| Product Name: | Vasopressin Recombinant Protein |
| Product Code: | RPPB1386 |
| Size: | 25mg |
| Target: | Vasopressin |
| Synonyms: | Vasopressin-neurophysin 2-copeptin, AVP-NPII, VP, ADH, ARVP, AVRP, Argipressin, Arginine vasopressin, AVP, Vasopressin, Antidiuretic Hormone. |
| Physical Appearance: | Sterile Filtered White lyophilized (freeze-dried) powder. |
| Formulation: | The protein (1 mg/ml) was lyophilized with no additives. |
| Solubility: | It is recommended to reconstitute the lyophilized Vasopressin in sterile 18M?-cm H2O not less than 100 µg/ml, which can then be further diluted to other aqueous solutions. |
| Stability: | Lyophilized Vasopressin although stable at room temperature for 3 weeks, should be stored desiccated below -18°C. Upon reconstitution Vasopressin should be stored at 4°C between 2-7 days and for future use below -18°C.For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).Please prevent freeze-thaw cycles. |
| Purity: | Greater than 98.0% as determined by by RP-HPLC. |
| Amino Acid Sequence: | C[Cys-Tyr-Phe-Gln-Asn-Cys]-Pro-Arg-Gly-NH2 |
Arginine vasopressin (AVP), also known as argipressin or antidiuretic hormone (ADH), is a human hormonethat is released when the body is low on water; it causes the kidneysto conserve water, but not salt, by concentrating the urineand reducing urine volume. It also raises blood pressure by inducing moderate vasoconstriction. It has various effects in the brain.A very similar substance, lysine vasopressin (LVP) or lypressin, has the same function in pigsand is often used in human therapy.Vasopressin is a peptide hormone. It is derived from a preprohormoneprecursor that is synthesized in the hypothalamus, from which it is liberated during transport to the posterior pituitary. Most of it is stored in the posterior partof the pituitary glandto be released into the blood stream; some of it is also released directly into the brain.AVP allows water reabsorption by the introduction of additional water channels in cortical and inner medullary collecting ducts.
ProSpec’s 8-L-Arginine Vasopressin’s molecular weight is 1084.24 Dalton and the molecular formula is: C46H65N15O12S2.
| UniProt Protein Function: | AVP: Neurophysin 2 specifically binds vasopressin. Defects in AVP are the cause of diabetes insipidus, neurohypophyseal (NDI). A disease characterized by persistent thirst, polydipsia and polyuria. Affected individuals are apparently normal at birth, but characteristically develop symptoms of vasopression deficiency during childhood. Belongs to the vasopressin/oxytocin family. |
| UniProt Protein Details: | Protein type:Secreted; Secreted, signal peptide; Hormone Chromosomal Location of Human Ortholog: 20p13 Cellular Component: cytosol; dendrite; extracellular region; extracellular space; secretory granule Molecular Function:caspase inhibitor activity; neurohypophyseal hormone activity; neuropeptide hormone activity; protein kinase activity; receptor binding; signal transducer activity; V1A vasopressin receptor binding; V1B vasopressin receptor binding Biological Process: cell-cell signaling; circadian rhythm; elevation of cytosolic calcium ion concentration; generation of precursor metabolites and energy; grooming behavior; hyperosmotic salinity response; locomotory behavior; maternal behavior; negative regulation of apoptosis; negative regulation of caspase activity; negative regulation of female receptivity; negative regulation of transmission of nerve impulse; penile erection; positive regulation of cAMP biosynthetic process; positive regulation of cell growth; positive regulation of cell proliferation; positive regulation of cellular pH reduction; positive regulation of glutamate secretion; positive regulation of peptidyl-serine phosphorylation; positive regulation of prostaglandin biosynthetic process; positive regulation of systemic arterial blood pressure; positive regulation of vasoconstriction; renal water homeostasis; response to ethanol; response to nicotine; response to testosterone stimulus; signal transduction; social behavior; sodium-independent organic anion transport; transmembrane transport; vasoconstriction; water transport Disease: Diabetes Insipidus, Neurohypophyseal |
| NCBI Summary: | This gene encodes a member of the vasopressin/oxytocin family and preproprotein that is proteolytically processed to generate multiple protein products. These products include the neuropeptide hormone arginine vasopressin, and two other peptides, neurophysin 2 and copeptin. Arginine vasopressin is a posterior pituitary hormone that is synthesized in the supraoptic nucleus and paraventricular nucleus of the hypothalamus. Along with its carrier protein, neurophysin 2, it is packaged into neurosecretory vesicles and transported axonally to the nerve endings in the neurohypophysis where it is either stored or secreted into the bloodstream. The precursor is thought to be activated while it is being transported along the axon to the posterior pituitary. Arginine vasopressin acts as a growth factor by enhancing pH regulation through acid-base transport systems. It has a direct antidiuretic action on the kidney, and also causes vasoconstriction of the peripheral vessels. This hormone can contract smooth muscle during parturition and lactation. It is also involved in cognition, tolerance, adaptation and complex sexual and maternal behaviour, as well as in the regulation of water excretion and cardiovascular functions. Mutations in this gene cause autosomal dominant neurohypophyseal diabetes insipidus (ADNDI). This gene is present in a gene cluster with the related gene oxytocin on chromosome 20. [provided by RefSeq, Nov 2015] |
| UniProt Code: | P01185 |
| NCBI GenInfo Identifier: | 13259533 |
| NCBI Gene ID: | 551 |
| NCBI Accession: | NP_000481.2 |
| UniProt Secondary Accession: | P01185,O14935, A0AV35, |
| UniProt Related Accession: | P01185 |
| Molecular Weight: | 17,325 Da |
| NCBI Full Name: | vasopressin-neurophysin 2-copeptin preproprotein |
| NCBI Synonym Full Names: | arginine vasopressin |
| NCBI Official Symbol: | AVP |
| NCBI Official Synonym Symbols: | VP; ADH; ARVP; AVRP; AVP-NPII |
| NCBI Protein Information: | vasopressin-neurophysin 2-copeptin |
| UniProt Protein Name: | Vasopressin-neurophysin 2-copeptin |
| UniProt Synonym Protein Names: | AVP-NPII |
| Protein Family: | Vasopressin-neurophysin 2-copeptin |
| UniProt Gene Name: | AVP |
| UniProt Entry Name: | NEU2_HUMAN |
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