VANGL1 Antibody (PACO44811)
제품 코드를 사용하여 Assay Genie 메인 사이트를 통해 주문합니다.
주문- SKU:
- PACO44811
- Product type:
- Antibody
- Reactivity:
- Human
- Host Species:
- Rabbit
- Isotype:
- IgG
- Application:
- ELISA
- Application:
- WB
- Application:
- IHC
- Antibody type:
- Polyclonal
- Conjugation:
- Unconjugated
Frequently bought together:
Description
Antibody Name: | VANGL1 Antibody (PACO44811) |
Antibody SKU: | PACO44811 |
Size: | 50ul |
Host Species: | Rabbit |
Tested Applications: | ELISA, WB, IHC |
Recommended Dilutions: | ELISA:1:2000-1:10000, WB:1:1000-1:5000, IHC:1:20-1:200 |
Species Reactivity: | Human |
Immunogen: | Recombinant Human Vang-like protein 1 protein (275-524AA) |
Form: | Liquid |
Storage Buffer: | PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
Purification Method: | Antigen Affinity Purified |
Clonality: | Polyclonal |
Isotype: | IgG |
Conjugate: | Non-conjugated |
Western blot. All lanes: VANGL1 antibody at 3.38µg/ml. Lane 1: PC-3 whole cell lysate. Lane 2: Hela whole cell lysate. Secondary. Goat polyclonal to rabbit IgG at 1/10000 dilution. Predicted band size: 60 kDa. Observed band size: 60 kDa.. | |
Immunohistochemistry of paraffin-embedded human ovarian cancer using PACO44811 at dilution of 1:100. | |
Immunohistochemistry of paraffin-embedded human colon cancer using PACO44811 at dilution of 1:100. |
Background: | Wnt signaling pathway, planar cell polarity pathway |
Synonyms: | Vang-like protein 1 (Loop-tail protein 2 homolog) (LPP2) (Strabismus 2) (Van Gogh-like protein 1), VANGL1, STB2 |
UniProt Protein Function: | VANGL1: Defects in VANGL1 are a cause of neural tube defects (NTD). NTD are congenital malformations. The most common forms of NTD are described as open defects (including anencephaly and myelomeningocele, or spina bifida), which result from the failure of fusion in the cranial and spinal region of the neural tube, respectively. Other open dysraphisms (including myeloschisis, hemimyelomeningocele, and hemimyelocele) are sometimes associated with a Chiari type 2 malformation. A number of skin-covered (closed) NTD are categorized clinically depending on the presence of a subcutaneous mass (lipomyeloschisis, lipomyelomeningocele, meningocele, and myelocystocele) or the absence of such a mass (complex dysraphic states, including split cord malformations, dermal sinus, caudal regression, and segmental spinal dysgenesis). Defects in VANGL1 are a cause of sacral defect with anterior meningocele (SDAM). SDAM is a form of caudal dysgenesis. It is present at birth and becomes symptomatic later in life, usually because of obstructive labor in females, chronic constipation, or meningitis. Inheritance is autosomal dominant. Belongs to the Vang family. 2 isoforms of the human protein are produced by alternative splicing. |
UniProt Protein Details: | Protein type:Membrane protein, integral; Adaptor/scaffold; Membrane protein, multi-pass; Motility/polarity/chemotaxis Chromosomal Location of Human Ortholog: 1p13.1 Molecular Function:protein binding Disease: Neural Tube Defects; Sacral Defect With Anterior Meningocele |
NCBI Summary: | This gene encodes a member of the tretraspanin family. The encoded protein may be involved in mediating intestinal trefoil factor induced wound healing in the intestinal mucosa. Mutations in this gene are associated with neural tube defects. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Feb 2010] |
UniProt Code: | Q8TAA9 |
NCBI GenInfo Identifier: | 40807121 |
NCBI Gene ID: | 81839 |
NCBI Accession: | BC065272 |
UniProt Secondary Accession: | Q8TAA9,Q5T1D3, Q5T1D4, Q86WG8, Q8N559, |
UniProt Related Accession: | Q8TAA9 |
Molecular Weight: | 59,748 Da |
NCBI Full Name: | Homo sapiens vang-like 1 (van gogh, Drosophila), mRNA |
NCBI Synonym Full Names: | VANGL planar cell polarity protein 1 |
NCBI Official Symbol: | VANGL1 |
NCBI Official Synonym Symbols: | LPP2; STB2; STBM2; KITENIN |
NCBI Protein Information: | vang-like protein 1 |
UniProt Protein Name: | Vang-like protein 1 |
UniProt Synonym Protein Names: | Loop-tail protein 2 homolog; LPP2; Strabismus 2; Van Gogh-like protein 1 |
Protein Family: | Vang-like protein |
UniProt Gene Name: | VANGL1 |
UniProt Entry Name: | VANG1_HUMAN |