USP6 Antibody (PACO50090)
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주문- SKU:
- PACO50090
- Product type:
- Antibody
- Reactivity:
- Human
- Reactivity:
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Application:
- ELISA
- Application:
- WB
- Application:
- IHC
- Application:
- IF
- Antibody type:
- Polyclonal
- Conjugation:
- Unconjugated
Frequently bought together:
Description
Antibody Name: | USP6 Antibody (PACO50090) |
Antibody SKU: | PACO50090 |
Size: | 50ug |
Host Species: | Rabbit |
Tested Applications: | ELISA, WB, IHC, IF |
Recommended Dilutions: | ELISA:1:2000-1:10000, WB:1:500-1:5000, IHC:1:20-1:200, IF:1:50-1:200 |
Species Reactivity: | Human, Rat |
Immunogen: | Recombinant Human Ubiquitin carboxyl-terminal hydrolase 6 protein (1122-1359AA) |
Form: | Liquid |
Storage Buffer: | Preservative: 0.03% Proclin 300 Constituents: 50% Glycerol, 0.01M PBS, pH 7.4 |
Purification Method: | >95%, Protein G purified |
Clonality: | Polyclonal |
Isotype: | IgG |
Conjugate: | Non-conjugated |
![]() | Western Blot. Positive WB detected in: Rat kidney tissue. All lanes: USP6 antibody at 4µg/ml. Secondary. Goat polyclonal to rabbit IgG at 1/50000 dilution. Predicted band size: 159, 122, 90 kDa. Observed band size: 159 kDa.. |
![]() | Immunofluorescent analysis of HepG2 cells using PACO50090 at dilution of 1:100 and Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L). |
![]() | Immunohistochemistry of paraffin-embedded human ovarian cancer using PACO50090 at dilution of 1:100. |
Background: | Deubiquitinase with an ATP-independent isopeptidase activity, cleaving at the C-terminus of the ubiquitin moiety. Catalyzes its own deubiquitination. In vitro, isoform 2, but not isoform 3, shows deubiquitinating activity. Promotes plasma membrane localization of ARF6 and selectively regulates ARF6-dependent endocytic protein trafficking. Is able to initiate tumorigenesis by inducing the production of matrix metalloproteinases following NF-kappa-B activation. |
Synonyms: | Ubiquitin carboxyl-terminal hydrolase 6 (EC 3.4.19.12) (Deubiquitinating enzyme 6) (Proto-oncogene TRE-2) (Ubiquitin thioesterase 6) (Ubiquitin-specific-processing protease 6), USP6, HRP1 TRE2 |
UniProt Protein Function: | USP6: Deubiquitinase with an ATP-independent isopeptidase activity, cleaving at the C-terminus of the ubiquitin moiety. Catalyzes its own deubiquitination. In vitro, isoform 2, but not isoform 3, shows deubiquitinating activity. Promotes plasma membrane localization of ARF6 and selectively regulates ARF6- dependent endocytic protein trafficking. Is able to initiate tumorigenesis by inducing the production of matrix metalloproteinases following NF-kappa-B activation. A chromosomal aberration involving USP6 is a common genetic feature of aneurysmal bone cyst, a benign osseous neoplasm. Translocation t(16;17)(q22;p13) with CDH11. The translocation generates a fusion gene in which the strong CDH11 promoter is fused to the entire USP6 coding sequence, resulting in USP6 transcriptional up-regulation. Belongs to the peptidase C19 family. 3 isoforms of the human protein are produced by alternative splicing. |
UniProt Protein Details: | Protein type:Oncoprotein; Ubiquitin-specific protease; Protease; EC 3.4.19.12 Chromosomal Location of Human Ortholog: 17p13 Cellular Component: cytoplasm; lysosome; plasma membrane; recycling endosome Molecular Function:calmodulin binding; cysteine-type endopeptidase activity; nucleic acid binding; protein binding; ubiquitin-specific protease activity Biological Process: protein deubiquitination |
UniProt Code: | P35125 |
NCBI GenInfo Identifier: | 50403738 |
NCBI Gene ID: | 9098 |
NCBI Accession: | P35125.2 |
UniProt Secondary Accession: | P35125,Q15634, Q86WP6, Q8IWT4, |
UniProt Related Accession: | P35125 |
Molecular Weight: | 89,577 Da |
NCBI Full Name: | Ubiquitin carboxyl-terminal hydrolase 6 |
NCBI Synonym Full Names: | ubiquitin specific peptidase 6 |
NCBI Official Symbol: | USP6 |
NCBI Official Synonym Symbols: | HRP1; TRE2; TRE17; Tre-2; TRESMCR; USP6-short |
NCBI Protein Information: | ubiquitin carboxyl-terminal hydrolase 6 |
UniProt Protein Name: | Ubiquitin carboxyl-terminal hydrolase 6 |
UniProt Synonym Protein Names: | Deubiquitinating enzyme 6; Proto-oncogene TRE-2; Ubiquitin thioesterase 6; Ubiquitin-specific-processing protease 6 |
Protein Family: | USP6 N-terminal-like protein |
UniProt Gene Name: | USP6 |
UniProt Entry Name: | UBP6_HUMAN |
Antibodies |
Anti-USP6 Antibody (CAB13255) |
Secondary Antibody |
Anti-HRP Goat Anti-Rabbit IgG (H+L) Antibody (CABS014) |
Recommended Products |
Anti-FITC Goat Anti-Rabbit IgG (H+L) Antibody (CABS011) |
Anti-HRP-conjugated Beta Actin Antibody (CABC028) |