UFM1 Antibody (PACO50086)
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주문- SKU:
- PACO50086
- Product type:
- Antibody
- Reactivity:
- Human
- Host Species:
- Rabbit
- Isotype:
- IgG
- Application:
- ELISA
- Application:
- IHC
- Antibody type:
- Polyclonal
- Conjugation:
- Unconjugated
Frequently bought together:
Description
Antibody Name: | UFM1 Antibody (PACO50086) |
Antibody SKU: | PACO50086 |
Size: | 50ug |
Host Species: | Rabbit |
Tested Applications: | ELISA, IHC |
Recommended Dilutions: | ELISA:1:2000-1:10000, IHC:1:20-1:200 |
Species Reactivity: | Human |
Immunogen: | Recombinant Human Ubiquitin-fold modifier 1 protein (11-63AA) |
Form: | Liquid |
Storage Buffer: | Preservative: 0.03% Proclin 300 Constituents: 50% Glycerol, 0.01M PBS, pH 7.4 |
Purification Method: | >95%, Protein G purified |
Clonality: | Polyclonal |
Isotype: | IgG |
Conjugate: | Non-conjugated |
![]() | Immunohistochemistry of paraffin-embedded human colon cancer using PACO50086 at dilution of 1:100. |
Background: | Ubiquitin-like modifier which can be covalently attached via an isopeptide bond to substrate proteins as a monomer or a lysine-linked polymer. The so-called ufmylation, requires the UFM1-activating E1 enzyme UBA5, the UFM1-conjugating E2 enzyme UFC1, and the UFM1-ligase E3 enzyme UFL1. This post-translational modification on lysine residues of proteins may play a crucial role in a number of cellular processes. TRIP4 ufmylation may for instance play a role in nuclear receptors-mediated transcription. Other substrates may include DDRGK1 with which it may play a role in the cellular response to endoplasmic reticulum stress (Probable). |
Synonyms: | Ubiquitin-fold modifier 1, UFM1, C13orf20 |
UniProt Protein Function: | Ubiquitin-like modifier which can be covalently attached via an isopeptide bond to substrate proteins as a monomer or a lysine-linked polymer. The so-called ufmylation, requires the UFM1-activating E1 enzyme UBA5, the UFM1-conjugating E2 enzyme UFC1, and the UFM1-ligase E3 enzyme UFL1 (PubMed:15071506, PubMed:20018847). This post-translational modification on lysine residues of proteins may play a crucial role in a number of cellular processes. TRIP4 ufmylation may for instance play a role in nuclear receptors-mediated transcription (PubMed:25219498). Other substrates may include DDRGK1 with which it may play a role in the cellular response to endoplasmic reticulum stress (Probable). |
NCBI Summary: | UFM1 is a ubiquitin-like protein that is conjugated to target proteins by E1-like activating enzyme UBA5 (UBE1DC1; MIM 610552) and E2-like conjugating enzyme UFC1 (MIM 610554) in a manner analogous to ubiquitylation (see UBE2M; MIM 603173) (Komatsu et al., 2004 [PubMed 15071506]).[supplied by OMIM, Dec 2008] |
UniProt Code: | P61960 |
NCBI GenInfo Identifier: | 7705300 |
NCBI Gene ID: | 51569 |
NCBI Accession: | NP_057701 |
UniProt Secondary Accession: | P61960,Q14346, Q5VXS0, Q6IAG6, Q9CPX2, Q9NZF2, |
UniProt Related Accession: | P61960 |
Molecular Weight: | 11.1 kDa (103aa), confirmed by MALDI-TOF |
NCBI Full Name: | ubiquitin-fold modifier 1 isoform 1 |
NCBI Synonym Full Names: | ubiquitin fold modifier 1 |
NCBI Official Symbol: | UFM1 |
NCBI Official Synonym Symbols: | BM-002; C13orf20 |
NCBI Protein Information: | ubiquitin-fold modifier 1 |
UniProt Protein Name: | Ubiquitin-fold modifier 1 |
Protein Family: | Ufm1-specific protease |
UniProt Gene Name: | UFM1 |
Antibodies |
Anti-UFM1 Antibody (CAB15843) |
Secondary Antibody |
Anti-HRP Goat Anti-Rabbit IgG (H+L) Antibody (CABS014) |
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