UBE2D2 Antibody (PACO22679)
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주문- SKU:
- PACO22679
- Product type:
- Antibody
- Reactivity:
- Human
- Host Species:
- Rabbit
- Isotype:
- IgG
- Application:
- ELISA
- Application:
- WB
- Antibody type:
- Polyclonal
- Conjugation:
- Unconjugated
Frequently bought together:
Description
Antibody Name: | UBE2D2 Antibody (PACO22679) |
Antibody SKU: | PACO22679 |
Size: | 100ul |
Host Species: | Rabbit |
Tested Applications: | ELISA, WB |
Recommended Dilutions: | ELISA:1:2000-1:10000, WB:1:500-1:3000 |
Species Reactivity: | Human |
Immunogen: | Synthesized peptide derived from C-terminal of human UBE2D2. |
Form: | Liquid |
Storage Buffer: | Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. |
Purification Method: | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
Clonality: | Polyclonal |
Isotype: | IgG |
Conjugate: | Non-conjugated |
![]() | Western blot analysis of extracts from HeLa cells, A549 cells and K562 cells, using UBE2D2 antibody. |
Background: | Accepts ubiquitin from the E1 complex and catalyzes its covalent attachment to other proteins. In vitro catalyzes 'Lys-48'-linked polyubiquitination. Mediates the selective degradation of short-lived and abnormal proteins. Functions in the E6/E6-AP-induced ubiquitination of p53/TP53. Mediates ubiquitination of PEX5 and autoubiquitination of STUB1 and TRAF6. Involved in the signal-induced conjugation and subsequent degradation of NFKBIA, FBXW2-mediated GCM1 ubiquitination and degradation, MDM2-dependent degradation of p53/TP53 and the activation of MAVS in the mitochondria by DDX58/RIG-I in response to viral infection. Essential for viral activation of IRF3. |
Synonyms: | Ubiquitin-conjugating enzyme E2 D2; Ubiquitin carrier protein D2; Ubiquitin-conjugating enzyme E2(17)KB 2; Ubiquitin-conjugating enzyme E2-17 kDa 2; Ubiquitin-protein ligase D2 |
UniProt Protein Function: | UBE2D2: Accepts ubiquitin from the E1 complex and catalyzes its covalent attachment to other proteins. In vitro catalyzes 'Lys- 48'-linked polyubiquitination. Mediates the selective degradation of short-lived and abnormal proteins. Functions in the E6/E6-AP- induced ubiquitination of p53/TP53. Mediates ubiquitination of PEX5 and autoubiquitination of STUB1 and TRAF6. Involved in the signal-induced conjugation and subsequent degradation of NFKBIA, FBXW2-mediated GCM1 ubiquitination and degradation, MDM2-dependent degradation of p53/TP53 and the activation of MAVS in the mitochondria by DDX58/RIG-I in response to viral infection. Essential for viral activation of IRF3. Belongs to the ubiquitin-conjugating enzyme family. |
UniProt Protein Details: | Protein type:Ubiquitin ligase; EC 6.3.2.19; Ligase; Ubiquitin conjugating system Chromosomal Location of Human Ortholog: 5q31.2 Cellular Component: cytosol; nucleoplasm; protein complex; ubiquitin ligase complex Molecular Function:protein binding; ubiquitin-protein ligase activity Biological Process: protein autoubiquitination; protein modification process; protein polyubiquitination; protein ubiquitination; stimulatory C-type lectin receptor signaling pathway; T cell receptor signaling pathway; ubiquitin-dependent protein catabolic process |
NCBI Summary: | Regulated degradation of misfolded, damaged or short-lived proteins in eukaryotes occurs via the ubiquitin (Ub)-proteasome system (UPS). An integral part of the UPS system is the ubiquitination of target proteins and covalent linkage of Ub-containing proteins to form polymeric chains, marking them as targets for 26S proteasome-mediated degradation. Ubiquitination of proteins is mediated by a cascade of enzymes which includes E1 (ubiquitin activating), E2 (ubiquitin conjugating), and E3 (ubiquitin ligases) enzymes. This gene encodes a member of the E2 enzyme family. Substrates of this enzyme include the tumor suppressor protein p53 and peroxisomal biogenesis factor 5 (PEX5). Alternative splicing results in multiple transcript variants of this gene. [provided by RefSeq, May 2013] |
UniProt Code: | P62837 |
NCBI GenInfo Identifier: | 51338685 |
NCBI Gene ID: | 7322 |
NCBI Accession: | P62837.1 |
UniProt Secondary Accession: | P62837,P51669, Q3MN78, Q96RP6, D3DQC9, |
UniProt Related Accession: | P62837 |
Molecular Weight: | 13,635 Da |
NCBI Full Name: | Ubiquitin-conjugating enzyme E2 D2 |
NCBI Synonym Full Names: | ubiquitin conjugating enzyme E2 D2 |
NCBI Official Symbol: | UBE2D2 |
NCBI Official Synonym Symbols: | UBC4; PUBC1; UBCH4; UBC4/5; UBCH5B; E2(17)KB2 |
NCBI Protein Information: | ubiquitin-conjugating enzyme E2 D2 |
UniProt Protein Name: | Ubiquitin-conjugating enzyme E2 D2 |
UniProt Synonym Protein Names: | (E3-independent) E2 ubiquitin-conjugating enzyme D2 (EC:2.3.2.24 |
Protein Family: | Ubiquitin-conjugating enzyme |
UniProt Gene Name: | UBE2D2 |
UniProt Entry Name: | UB2D2_HUMAN |