UBASH3B Antibody (PACO44482)
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주문- SKU:
- PACO44482
- Product type:
- Antibody
- Reactivity:
- Human
- Host Species:
- Rabbit
- Isotype:
- IgG
- Application:
- ELISA
- Application:
- IHC
- Antibody type:
- Polyclonal
- Conjugation:
- Unconjugated
Frequently bought together:
Description
Antibody Name: | UBASH3B Antibody (PACO44482) |
Antibody SKU: | PACO44482 |
Size: | 50ul |
Host Species: | Rabbit |
Tested Applications: | ELISA, IHC |
Recommended Dilutions: | ELISA:1:2000-1:10000, IHC:1:20-1:200 |
Species Reactivity: | Human |
Immunogen: | Recombinant Human Ubiquitin-associated and SH3 domain-containing protein B protein (1-300AA) |
Form: | Liquid |
Storage Buffer: | PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
Purification Method: | Antigen Affinity Purified |
Clonality: | Polyclonal |
Isotype: | IgG |
Conjugate: | Non-conjugated |
![]() | Immunohistochemistry of paraffin-embedded human spleen tissue using PACO44482 at dilution of 1:100. |
![]() | Immunohistochemistry of paraffin-embedded human adrenal gland tissue using PACO44482 at dilution of 1:100. |
Background: | Interferes with CBL-mediated down-regulation and degradation of receptor-type tyrosine kinases. Promotes accumulation of activated target receptors, such as T-cell receptors and EGFR, on the cell surface. Exhibits tyrosine phosphatase activity toward several substrates including EGFR, FAK, SYK, and ZAP70. Down-regulates proteins that are dually modified by both protein tyrosine phosphorylation and ubiquitination. |
Synonyms: | Ubiquitin-associated and SH3 domain-containing protein B (EC 3.1.3.48) (Cbl-interacting protein p70) (Suppressor of T-cell receptor signaling 1) (STS-1) (T-cell ubiquitin ligand 2) (TULA-2) (Tyrosine-protein phosphatase STS1/TULA2), UBASH3B, KIAA1959 STS1 |
UniProt Protein Function: | STS-1: Interferes with CBL-mediated down-regulation and degradation of receptor-type tyrosine kinases. Promotes accumulation of activated target receptors, such as T-cell receptors and EGFR, on the cell surface. Exhibits tyrosine phosphatase activity toward several substrates including EGFR, FAK, SYK, and ZAP70. Down-regulates proteins that are dually modified by both protein tyrosine phosphorylation and ubiquitination. |
UniProt Protein Details: | Protein type:EC 3.1.3.48; Protein phosphatase, tyrosine (non-receptor) Chromosomal Location of Human Ortholog: 11q24.1 Cellular Component: cytoplasm; nucleus Molecular Function:protein binding; protein tyrosine phosphatase activity Biological Process: negative regulation of protein kinase activity; regulation of release of sequestered calcium ion into cytosol |
NCBI Summary: | This gene encodes a protein that contains a ubiquitin associated domain at the N-terminus, an SH3 domain, and a C-terminal domain with similarities to the catalytic motif of phosphoglycerate mutase. The encoded protein was found to inhibit endocytosis of epidermal growth factor receptor (EGFR) and platelet-derived growth factor receptor. [provided by RefSeq, Jul 2008] |
UniProt Code: | Q8TF42 |
NCBI GenInfo Identifier: | 110287974 |
NCBI Gene ID: | 84959 |
NCBI Accession: | Q8TF42.2 |
UniProt Related Accession: | Q8TF42 |
Molecular Weight: | |
NCBI Full Name: | Ubiquitin-associated and SH3 domain-containing protein B |
NCBI Synonym Full Names: | ubiquitin associated and SH3 domain containing B |
NCBI Official Symbol: | UBASH3B |
NCBI Official Synonym Symbols: | p70; STS1; STS-1; TULA2; TULA-2 |
NCBI Protein Information: | ubiquitin-associated and SH3 domain-containing protein B |
UniProt Protein Name: | Ubiquitin-associated and SH3 domain-containing protein B |
UniProt Synonym Protein Names: | Cbl-interacting protein p70; Suppressor of T-cell receptor signaling 1; STS-1; T-cell ubiquitin ligand 2; TULA-2; Tyrosine-protein phosphatase STS1/TULA2 |
UniProt Gene Name: | UBASH3B |
UniProt Entry Name: | UBS3B_HUMAN |