UBA1 Antibody (PACO20805)
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주문- SKU:
- PACO20805
- Product type:
- Antibody
- Reactivity:
- Human
- Reactivity:
- Mouse
- Reactivity:
- Rat
- Host Species:
- Rabbit
- Isotype:
- IgG
- Application:
- ELISA
- Application:
- WB
- Application:
- IHC
- Antibody type:
- Polyclonal
- Conjugation:
- Unconjugated
Frequently bought together:
Description
Antibody Name: | UBA1 Antibody (PACO20805) |
Antibody SKU: | PACO20805 |
Size: | 50ul |
Host Species: | Rabbit |
Tested Applications: | ELISA, WB, IHC |
Recommended Dilutions: | ELISA:1:1000-1:2000, WB:1:200-1:1000, IHC:1:30-1:150 |
Species Reactivity: | Human, Mouse, Rat |
Immunogen: | Synthetic peptide of human UBA1 |
Form: | Liquid |
Storage Buffer: | -20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol |
Purification Method: | Antigen affinity purification |
Clonality: | Polyclonal |
Isotype: | IgG |
Conjugate: | Non-conjugated |
![]() | Gel: 6%SDS-PAGE,Lysate: 40 μgPrimary antibody: PACO20805(UBA1 Antibody) at dilution 1/400 dilution,Secondary antibody: Goat anti rabbit IgG at 1/8000 dilution,Exposure time: 1 minute. |
![]() | The image on the left is immunohistochemistry of paraffin-embedded Human esophagus cancer tissue using PACO20805(UBA1 Antibody) at dilution 1/40, on the right is treated with synthetic peptide. (Original magnification: x200). |
Background: | The protein encoded by this gene catalyzes the first step in ubiquitin conjugation to mark cellular proteins for degradation. This gene complements an X-linked mouse temperature-sensitive defect in DNA synthesis, and thus may function in DNA repair. It is part of a gene cluster on chromosome Xp11.23. Alternatively spliced transcript variants that encode the same protein have been described. |
Synonyms: | ubiquitin-like modifier activating enzyme 1 |
UniProt Protein Function: | UBE1: an enzyme of the ubiquitin-activating E1 family. Adenylates ubiquitin at its carboxy-terminal glycine residue and thereafter links this residue to the side chain of a cysteine residue in E1, yielding an ubiquitin-E1 thiolester. There are two active sites within the E1 molecule, allowing it to accomodate two ubiquitin moieties at a time, with a new ubiquitin forming an adenylate intermediate as the previous one is transferred to the thiol site. Complements an X-linked mouse temperature-sensitive defect in DNA synthesis, and thus may function in DNA repair. |
UniProt Protein Details: | Protein type:Ubiquitin ligase; EC 6.3.2.19; Ubiquitin conjugating system Chromosomal Location of Human Ortholog: Xp11.23 Cellular Component: heterochromatin; desmosome; mitochondrion; lysosomal membrane; cytoplasm; endosome membrane; rough endoplasmic reticulum membrane; nucleus; cytosol Molecular Function:protein binding; ubiquitin-protein ligase activity; ubiquitin activating enzyme activity; ATP binding Biological Process: modification-dependent protein catabolic process; protein ubiquitination; response to DNA damage stimulus Disease: Spinal Muscular Atrophy, X-linked 2 |
NCBI Summary: | The protein encoded by this gene catalyzes the first step in ubiquitin conjugation to mark cellular proteins for degradation. This gene complements an X-linked mouse temperature-sensitive defect in DNA synthesis, and thus may function in DNA repair. It is part of a gene cluster on chromosome Xp11.23. Alternatively spliced transcript variants that encode the same protein have been described. [provided by RefSeq, Jul 2008] |
UniProt Code: | P22314 |
NCBI GenInfo Identifier: | 24418865 |
NCBI Gene ID: | 7317 |
NCBI Accession: | P22314.3 |
UniProt Secondary Accession: | P22314,Q5JRR8, Q96E13, |
UniProt Related Accession: | P22314 |
Molecular Weight: | 1058 |
NCBI Full Name: | Ubiquitin-like modifier-activating enzyme 1 |
NCBI Synonym Full Names: | ubiquitin-like modifier activating enzyme 1 |
NCBI Official Symbol: | UBA1 |
NCBI Official Synonym Symbols: | A1S9; A1ST; GXP1; UBE1; A1S9T; AMCX1; POC20; SMAX2; UBA1A; UBE1X; CFAP124 |
NCBI Protein Information: | ubiquitin-like modifier-activating enzyme 1; POC20 centriolar protein homolog; UBA1, ubiquitin-activating enzyme E1 homolog A; A1S9T and BN75 temperature sensitivity complementing |
UniProt Protein Name: | Ubiquitin-like modifier-activating enzyme 1 |
UniProt Synonym Protein Names: | Protein A1S9; Ubiquitin-activating enzyme E1 |
UniProt Gene Name: | UBA1 |
UniProt Entry Name: | UBA1_HUMAN |