UniProt Protein Function: | A6: Actin-binding protein involved in motile and morphological processes. Inhibits actin polymerization, likely by sequestering G-actin. By capping the barbed ends of filaments, it also regulates motility. Seems to play an important role in clathrin-mediated endocytosis and distribution of endocytic organelles. Interacts with G-actin; ADP-actin form and capping protein (CP). May also be able to interact with TWF2 and phosphoinositides, PI(4,5)P2. When bound to PI(4,5)P2, it is down- regulated. Expressed at high levels in the colon, testis, ovary, prostate and lung. Expressed at lower levels in the brain, bladder and heart. Not detected in liver. Belongs to the actin-binding proteins ADF family. Twinfilin subfamily. 3 isoforms of the human protein are produced by alternative splicing. |
UniProt Protein Details: | Protein type:Motility/polarity/chemotaxis Chromosomal Location of Human Ortholog: 12q12 Cellular Component: actin cytoskeleton; cytoplasm; filopodium; focal adhesion; intercellular junction; myofibril; perinuclear region of cytoplasm Molecular Function:actin monomer binding; ATP binding; phosphatidylinositol-4,5-bisphosphate binding; protein-tyrosine kinase activity Biological Process: negative regulation of actin filament polymerization; regulation of actin phosphorylation; sequestering of actin monomers |
NCBI Summary: | This gene encodes twinfilin, an actin monomer-binding protein conserved from yeast to mammals. Studies of the mouse counterpart suggest that this protein may be an actin monomer-binding protein, and its localization to cortical G-actin-rich structures may be regulated by the small GTPase RAC1. [provided by RefSeq, Jul 2008] |
UniProt Code: | Q12792 |
NCBI GenInfo Identifier: | 259016376 |
NCBI Gene ID: | 5756 |
NCBI Accession: | Q12792.3 |
UniProt Secondary Accession: | Q12792,Q59G07, Q5U0B1, Q6FHJ1, Q6FHL6, Q6NUK9, Q86XL6 Q8TCD3, A8K5A8, B3KXS6, B4DLX9, |
UniProt Related Accession: | Q12792 |
Molecular Weight: | 28,823 Da |
NCBI Full Name: | Twinfilin-1 |
NCBI Synonym Full Names: | twinfilin actin binding protein 1 |
NCBI Official Symbol: | TWF1 |
NCBI Official Synonym Symbols: | A6; PTK9 |
NCBI Protein Information: | twinfilin-1 |
UniProt Protein Name: | Twinfilin-1 |
UniProt Synonym Protein Names: | Protein A6; Protein tyrosine kinase 9 |
Protein Family: | Twinfilin |
UniProt Gene Name: | TWF1 |
UniProt Entry Name: | TWF1_HUMAN |